Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease.

Completed

• Conditions: Frailty; Cognitive Impairment; CKD Stage 5; CKD Stage 4

• Registration Number: NCT05705011
• Lead Sponsor: Grigore T. Popa University of Medicine and Pharmacy

Brief Summary

This observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease \].

The main question\[s\] it aims to answer are:

* What determines the time to initiate dialysis? Cognitive impairment or frailty?

* What does predict the time to death? Presence of frailty or cognitive impairment?

* What does correlate strongly with time-low health-related quality of life? frailty or cognitive impairment?

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-01
• Study First Submitted: 2023-01-21
• Study First Submitted QC: 2023-01-21
• Study First Posted: 2023-01-30
• Primary Completion: 2023-03-05
• Study Completion: 2023-03-12
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-14
• Last Update Posted: 2024-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

• Patients age 65 years or older.
• CKD stage 4 and 5 who were identified by two consecutive measurements of estimated glomerular filtration rate (eGFR) <30 mL/min/1.73 m2 separated by more than 3 months.

Exclusion Criteria

• Patients younger than 65 years old.
• Chronic kidney disease stages 1,2, and 3.
• Dialysis dependence
• History of kidney transplantation.
• Initial visit with the health care provider.
• Recent acute kidney injury.
• Patients who had been hospitalized for more than 2 months before the visit (because long hospitalization might affect the degree of frailty)
• Patients with myocardial infarction and cerebrovascular accident 3 months before the assessment
• Patients who are blind or with limb amputation.
• Patients who refuse to participate.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to initiate dialysis.	36 months	The time from the assessment moment to start dialysis of an older adult with advanced CKD (
Time to death	36 months	The time from the assessment moment to death of an older adult with advanced CKD ( CKD stage 4 and 5).

Trial Locations

Locations (1)

University of Medicine and Pharmacy "Grigore T. Popa"; 🇷🇴 Iasi, Romania