Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area (SII) and Insula : an fMRI Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Comparison of euclidian distances between the centroids of clusters activations for the different types of stimulations into SII and insula.
研究概览
简要总结
The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory inputs is now well established. However the functional anatomy of these areas hidden in the depth of the sylvian scissure remain mostly unknown.
The aim of this fMRI study is to determine the functional cartography of SII and insula. The localization of responses to different somatosensory stimuli (slight touch, warm, cold, heat pain and arthrokinesia) applied on the left hand of 25 healthy volunteers, will be compared.
详细描述
Aims : Demonstrate that localization of the several types of somatosensory stimuli is different into SII and into insula. If possible, we'll determine a functional cartography of these areas.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •25 healthy volunteers will be included ranging in age from 18 to 50 years
- •contraception needed for women
- •right handed
- •All the subjects have to give their written informed consent.
排除标准
- •pregnancy
- •neurological or psychiatric disease
- •drugs taken <12h before fMRI
- •contra-indications to fMRI : pacemaker, clip, metallic device
- •Refusing to be informed of the presence of a cerebral abnormality, detected during MRI.
结局指标
主要结局
Comparison of euclidian distances between the centroids of clusters activations for the different types of stimulations into SII and insula.
时间窗: one day
次要结局
- Determine the Talairach coordinates of the centroids of clusters of activations for the different types of somatosensory stimuli into SII and insula(one day)