Modulation of cerebral somatosensory processing and nociception by treatment with botulinum toxin A in spasticity and dystonia

• Conditions: G24.9; R25.2; Dystonia, unspecified; Cramp and spasm

• Registration Number: DRKS00003696
• Lead Sponsor: Klinik f. NeurologieFSU Jena

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Group 1 (dystonia): evidence of cervical dystonia by a specialist for Neurology, exclusion of other causes for dystonia-like symptomes, right-handed, no other neurological diseases, no pre-medication, MRI compatibility

Group 2 (spasticity): evidence of clinically significant spasticity of the right side of the body following an ischemic infarction by a media, right-handed, no other neurological diseases, no relevant pre-medication, MRI compatibility

Exclusion Criteria

Psychiatric comorbidity, counter indication for MRI

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Treatment response in group 1 (dystonia) and group 2 (spasticity) after 12 months under treatment with botulinum toxin:<br>- Dystonia: UDRS (Unified Dystonia Rating Scale), TWSTRS (Toronto Western Spasmodic Torticollis Rating Scale)<br>- Spasticity: MAS (Mod Ashworth scale), SERS (Spasticity Examination Rating Scale)

Secondary Outcome Measures

Name	Time	Method
Pain reduction (interview with German Pain Questionnaire) at 0, 3 and 12 months