Assessment and review of cognition, Alzheimer's disease and inflammation after hospital interventio

Not Applicable

Completed

• Conditions: Alzheimer's disease; Dementia; Inflammation; Neurological - Dementias; Anaesthesiology - Anaesthetics; Surgery - Other surgery

• Registration Number: ACTRN12615001070527
• Lead Sponsor: St Vincent's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-10-13
• Study Completion: 2019-06-03
• Last Update Posted: 24 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1. Aged 60 years or older
2. Scheduled for elective health care procedure
3. No contraindication to neuropsychological testing (eg. language, significant depression, deaf or blind)
4. Live within a reasonable proximity of St Vincent's Hospital (for home neuropsychological assessments)
5. Expected length of hospital stay of 3 days or more

Exclusion Criteria

1. Pre-existing neurological or clinically evident nerovascular disease (eg stroke)
2. Mini Mental State Examination of 26 and below
3. Anticipated difficulty with neuropsychological assessment
4. Inaccessibility (patients living over 1 hour drive from Melbourne)
5. Age (patients less than 60 years of age)
6. Anticipated length of stay in hospital less than 3 days

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identify association between high levels of interleukin-6 (IL-6) at baseline and the incidence of postoperative cognitive dysfunction as measured by a neuropsychological test battery at 3 months following surgery.[Neuropsychological testing at baseline (prior to surgery) and 3 months postoperatively will be undertaken at the patient's home. Blood samples will be taken prior to anaesthetic induction as a baseline measurement and again at 30 minutes following surgical incision and at 6, 24 and 48 hours following surgery. ]