Alzheimer's disease, cognition and cerebrospinal fluid: Are they associated?

Not Applicable

Completed

• Conditions: Alzheimer's Disease; Cerebrospinal fluid (CSF) predictors of cognitive change and Alzheimer's diseae; Anaesthesiology - Anaesthetics; Effect of anaesthesia and surgery on cognition; Neurological - Alzheimer's disease; Mental Health - Studies of normal psychology, cognitive function and behaviour

• Registration Number: ACTRN12612000493842
• Lead Sponsor: St. Vincent's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-05-07
• Study Completion: 2016-04-04
• Last Update Posted: 24 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

Patients aged 60y or more who are scheduled for elective total hip joint replacement (THJR) or total knee joint replacement (TKJR) who do not have neurological deficit; give informed consent; have no contraindication to neuropsychological testing; and reside in accessible proximity to the hospital to enable investigators to administer neuropsychological testing at patients' home.

Exclusion Criteria

Pre-existing neurological or clinically evident neurovascular disease (eg. stroke); Clnical Dementia Rating score >=1 (exclude frank dementia); anticipated difficulty with neuropsychological assessment, such as English not being the prime language, blindness, deafness; associated medical problems that may lead to significant loss to follow-up (ASA physical status IV or higher); geographical remoteness.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the extent to which a pre-operative CSF signature of Alzheimer's disease (amyloid beta 1-42; total-tau and phospho-tau) predicts postoperative cognitive dysfunction (POCD) and increase in clinical dementia rating (CDR) scale in elderly patients who receive general anaesthesia for orthopaedic surgery.[Baseline, 3, 12 and 18 months postoperatively]

Secondary Outcome Measures

Name	Time	Method
To identify an association between POCD, Mild Cognitive Impairment (MCI) and dementia. Baseline cognitive and functional data collected at baseline assessment will be compared with 3, 12 and 18 month follow-ups cognitive and functional assessment to measure cognitive outcomes and risk of dementia. [Baseline, 3, 12 and 18 months postoperatively];To identify risk factors for POCD and progressive cognitive decline (MCI and dementia) after anaesthesia and surgery.<br>Medical history details of risk factors will be collected from the patient at baseline and verified by the patient's medical record.[Baseline and 3 months postoperatively];Exploratory analyses of the blood samples will be undertaken to identify known and unknown biomarkers for cognition and neuronal injury.[baseline, 30 min, 6, 24 and 48 hours post surgery.]