Establishment of dementia onset and progression model considering relevant high-risk genes after COVID-19 infection in dementia high-risk group

Not Applicable

Recruiting

• Conditions: Mental and behavioural disorders

• Registration Number: KCT0007688
• Lead Sponsor: The Catholic University of Korea, Seoul St. Mary's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 October 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

? 55 years old or older and 85 years old or older
? Subjects who agreed to participate in this study
? Those who can participate in all the tests (comprehensive neuropsychological test, brain MRI, blood test) performed when participating in this study
? Satisfying mild cognitive impairment according to NIA-AA (National Institute on Aging-Alzheimer's Association) diagnostic criteria through structured interview with a psychiatrist.
? Clinical Dementia Rating (CDR): 0.5 points

Exclusion Criteria

? Those diagnosed with the following neurological diseases cannot participate in this study.
· Major neurodegenerative diseases such as Parkinson's disease and Huntington's disease
· Brain lesions accompanied by neurological disorders: brain tumor, progressive supranuclear palsy
Convulsive disorders that can cause Generalized Tonic-Clonic Seizures (GTCS)
Brain diseases that can cause secondary dementia, such as carbon monoxide poisoning or alcoholic dementia
? Those who have a history of abuse or dependence on alcohol or drugs within the past 2 years at the time of clinical research registration
? Those with medical conditions that can cause mental abnormalities - thyroid, liver disease, kidney disease, etc. The evaluation of the subject's disease is based on the medical judgment of the investigator
· Except for cases that may significantly interfere with neuropsychological evaluation due to the use of drugs such as antidepressants, antipsychotics, antianxiety drugs, or sedatives and sedatives according to the medical judgment of a specialist
? When other investigators judge that it is inappropriate to participate in clinical research.

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sub-domain scores of neuropsychological assessment battery; Total score of neuropsychological assessment battery; Parameter of brain thickness and volume; Parameter of brain function

Secondary Outcome Measures

Name	Time	Method
Amyloid and tau pathology test using blood sample; blood inflammatory marker