Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- Clinical muscle tone tests
研究概览
简要总结
In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury. The alternation of muscular property was accompanied by the alternation of spinal circuitry property, and was related to the immobilization adaptation. Previous study showed that remobilization by continuous passive motion (CPM) for one month would restore the function of spinal circuitry in individual with chronic SCI. It is possible that long term application of CPM can reverse the adaptation of contractile properties of the paralyzed muscle after SCI. The purpose of this study is to investigate the effect of a four month CPM training on muscular properties in individuals with chronic SCI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of complete spinal cord injury
排除标准
- 未提供
研究组 & 干预措施
SCI
SCI participated in a 4-month robot-assisted passive ankle exercise regimen.
干预措施: Ankle continuous passive motion machine. (Procedure)
结局指标
主要结局
Clinical muscle tone tests
时间窗: Baseline, 1 month, 2 months, 3 months, and 4 months
Measure of changes in clinical muscle tone tests of soleus and tibialis anterior by Modified Ashworth Scale.
The contractile properties of the muscles
时间窗: Baseline, 1 month, 2 months, 3 months, and 4 months
Measure of changes in contractile properties of soleus and tibialis anterior
Fatigue index
时间窗: Baseline, 1 month, 2 months, 3 months, and 4 months
Measure of changes in Fatigue index of soleus and tibialis anterior.
Patient Reported Impact of Spasticity Measure (PRISM)
时间窗: Baseline, 1 month, 2 months, 3 months, and 4 months
Measure of changes in PRISM.
The potential adverse effects of ankle swelling
时间窗: Baseline, 1 month, 2 months, 3 months, and 4 months
Measure of changes in the potential adverse effects of ankle swelling.
次要结局
未报告次要终点
研究者
Ya-Ju Chang
Professor
Chang Gung University