Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Alzheimer Disease
- Sponsor
- Centre Hospitalier Universitaire, Amiens
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- tests of social cognition (questionnaire)
- Status
- Terminated
- Last Updated
- 6 years ago
Overview
Brief Summary
The role of disorders of socio-emotional processes in cerebral diseases such as Alzheimer's disease, frontal temporal dementia, Parkinson's disease, Huntington's disease, traumatic brain injury, stroke, focal lesions, has been recognized recently. Social cognition refers to a large group of emotional and cognitive abilities regulating inter-individuals relationships and it includes mainly theory of mind, emotional information processing and empathy. However, assessment of socio-emotional processes is still largely based on experimental tests that are not validated for clinical purpose. In addition their long duration of administration is not adapted to clinical examination. Finally these tests have not been standardized and normalized in French-speaking population.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Provision of signed and dated informed consent form (ICF)
- •Male or female, aged 20 to 80 years inclusive at the time of signing ICF
- •French-speaking
- •reliable informant
- •derived from the general population and consenting to participate in the study
- •Patients followed for mild or major neurocognitive disorder related to :
- •Alzheimer's disease
- •Frontotemporal lobar degeneration
- •Lewy bodies disease
- •Parkinson's disease
Exclusion Criteria
- •mental retardation
- •visual or motor deficit preventing reading, drawing or writing (scores on the reading, drawing or sentence writing subtests of the MMSE = 0)
- •hearing impairment interfering with understanding of instructions,
- •history of brain disease, including head injury with loss of consciousness lasting \> 15 minutes, stroke, coma or loss of consciousness lasting \> 15 minutes, followed for sclerosis or other brain disease, brain radiation therapy, epilepsy currently requiring treatment
- •history of psychiatric illness (schizophrenia or other psychosis) or ongoing psychiatric illness (major depressive disorder or other condition) currently requiring treatment or requiring a stay \> 2 days in a psychiatry unit or anxiety requiring more than one medication at the present time
- •alcoholism (mean alcohol consumption \> 3 standard drinks/day or history of alcohol withdrawal)
- •use of opiates or other illicit drugs during the previous 3 months or causing withdrawal syndrome
- •ongoing antidepressant or antiepileptic treatment
- •anxiolytic or hypnotic treatment initiated or increased during the previous month
- •general anaesthesia during the previous 3 months
Outcomes
Primary Outcomes
tests of social cognition (questionnaire)
Time Frame: 3 years
standardize and validate in French-speaking population a comprehensive battery of tests of social cognition