Ecological Assessment of Apathy in Alzheimer's Disease and in Control Subjects: Video Recognition and Actigraphy

Not Applicable

Completed

• Conditions: Alzheimer Disease
• Interventions: Other: observational

• Registration Number: NCT01384344
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Cognitive and memory disorders are characterized of Alzheimer disease. In addition, psychologic and behavioural symptoms, called speak neuropsychiatric symptoms, are frequents and play an important role in prognostic and intervention. These symptoms are noticed before the diagnostic of dementia, their prevalence and their intensity increase with the evolution of disease. Apathy, which is characterized by a decrease of motivation, is the most frequent of this behaviour disrupt. Clinically, a decrease, or a totally, lack of interest, initiative and blunting emotional are noticed. Fundamentally, apathy is considered as a decrease of cognition and behaviour to "go in goal". Assessment of psychological and behavioural symptoms is realised principally with neuropsychiatric scales. These contribute to obtain particular informations about health of patient allowing by patient and caregiver discussions and impressions of clinician. These scales are simples but loss of subjectivity. An alternative of this method is the use of gerontechnology as actigraphy (system out-patient which records locomotive activity with the help of piezo-electrical sensor fixed on a bracelet) and video recording which is associated to an informatic treatment of signal in order event recognition.

The aim of study is to realise an objective assessment of activities "go in goal" during experimental sequence which has well-characterized acts, using at the same time an actigraphic record of activity "motive" (system of assessment indirect of apathy fit) and a video records which uses an informatic event recognition system. The assessment will realise with participants controls (n=30) and Alzheimer disease patients with (n=20) or without (n=20) apathy, during well-characterized records. The final aim is to obtain a particular assessment of some disorders behaviours, as apathy, which is principally characterize by a decrease of behaviours "to go in goal".

Detailed Description

Not available

Study Timeline

• Status Verified: 2011-05
• Study First Submitted: 2011-05-27
• Study Start: 2011-06
• Study First Submitted QC: 2011-06-27
• Study First Posted: 2011-06-29
• Primary Completion: 2011-12
• Study Completion: 2012-06
• Last Update Submitted: 2012-12-17
• Last Update Posted: 2012-12-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

Not provided

Exclusion Criteria

• Impossibility of realization of the experimental protocol because of a driving handicap.
• Port(Bearing) of a pacemaker
• Under guardianship Patient or guardianship

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
witness	observational	no mnesic complaint
Alzheimer's disease without apathy	observational	Alzheimer's disease according to criteria of NINCDS-ADRDA without apathy
Alzheimer disease with apathy	observational	Alzheimer's disease according to criteria of NINCDS-ADRDA with apathy

Primary Outcome Measures

Name	Time	Method
stride and speed walking	one time point - at the only visit of protocol (day 1)

Secondary Outcome Measures

Name	Time	Method
For comparison between Alzheimer disease patients with (n=20) or without apathy, we use again stride and speed walking	one time point - at the only visit of protocol (day 1)
For reproducibility, we use stride and speed walking	one time point - at the only visit of protocol (day 1)
Reliability is the sum of posture's concordance	one time point - at the only visit of protocol (day 1)
Relation between LF/HF variations and activity index	one time point - at the only visit of protocol (day 1)

Trial Locations

Locations (1)

Hôpital de Cimiez; 🇫🇷 Nice, France