Pancreatic islet cell response to multiple stimuli in long standing diabetes mellitus type 1

Completed

• Conditions: 10018424; Diabetes mellitus type 1; juvenile Diabetes

• Registration Number: NL-OMON46034
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

Diagnosis of diabetes according to the ADA criteria for diagnosis of diabetes mellitus
At least 5 years after the first insulin injection
History and clinical course consistent with diabetes mellitus type 1

Exclusion Criteria

Having had an allergic reaction to arginine and/or GLP-1 (agonists)
Use of *-cell stimulants (e.g. sulphonylureas), GLP 1 agonist, dipeptidyl peptidase- IV inhibitors, insulin sensitizers (e.g. metformin, thiazolidinediones) in the 3 months before inclusion
Use of medication know to induce insulin resistance (e.g. corticosteroids) in the 3 months before inclusion
History of cardiovascular disease (cerebral, coronary or peripheral artery disease), kidney disease (eGFR <60 ml/min/1.73m-2 in the last year), liver disease or disease of the central nervous system

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- the delta maximum concentration of the C-peptide concentration in response to<br /><br>the individual stimuli</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- delta maximum concentration of the other biomarkers in response to the<br /><br>individual stimuli<br /><br>- Ratios of the C-peptide concentration at the clamp day and the C-peptide<br /><br>concentration at the meal test day after certain stimuli</p><br>