Pancreatic islet cell response to hypoglycaemia in long standing type 1 diabetes
Completed
- Conditions
- diabetes mellitus type 1Type 1 diabetes10018424
- Registration Number
- NL-OMON49391
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Type 1 diabetes
HbA1c <75 mmol/mol
BMI < 30kg/m2
Exclusion Criteria
History of epilepsy
Use of medicationknow to induce insulin resistance
Use of medication for diabetes other than insulin (analogs)
History of cardiovascular disease, kidney disease, liver disease or disease of
the central nervous system
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Change in serum C-peptide concentration<br /><br>- Time delay between plasma glucose and interstitial glucose measured by a FGM<br /><br>and/or implantable CGM during the emergence and the resolution of a<br /><br>hypoglycaemia<br /><br>- Difference in facial expression as determined by a deep learning module of<br /><br>Microsoft before, during and after hypoglycaemia<br /><br>- Difference in heart rate variability before, during and after hypoglycaemia</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Association of differences in facial expression and heart rate variability<br /><br>with counterregulatory mechanisms (norepinephrine, epinephrine, heart rate),<br /><br>hypoglycaemic symptoms (semiquantitive symptom questionnaire and simple<br /><br>cognitive testing)<br /><br>- Change in other products of the islets (for instance glucagon and<br /><br>proinsulin)</p><br>