Functional response of the hypothalamus to glucose ingestion in patients with anorexia nervosa.

• Conditions: Anorexia; 10014067; Anorexia Nervosa; 10021112

• Registration Number: NL-OMON32377
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Patients:
Female
Anorexia nervosa diagnosed according to DSM-IV criteria.
BMI 17.5 kg/m2 or less
Age 18 - 30 years;Healthy controls:
Female
18.5 kg/m2 <= BMI <= 22 kg/m2
Age 18 - 30 years
Using oral contraceptives
Not on a weight reducing diet
No change in weight of more than 3 kg over the last 2 months

Exclusion Criteria

Connected with anorexia nervosa
- Physical condition such that participating in this study is not recommended (as judged by the treating physician of Centrum Eetstoornissen Ursula).;Other
- Any genetic or somatic disease (e.g. fragile X syndrome,) affecting the brain
- Diabetes mellitus or history of diabetes mellitus in first grade relatives
- Any significant chronic disease
- Any substance abuse or addiction according to DSM-IV criteria (except smoking).;Contra-indication to MRI scanning:
- Claustrophobia
- Pacemakers and defibrillators
- Nerve stimulators
- Intracranial clips
- Intraorbital or intraocular metallic fragments
- Cochlear implants
- Ferromagnetic implants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in reaction pattern of neuronal activity (as measured with fMRI) in the<br /><br>hypothalamus in respons to intake of glucose in patients with anorexia nervosa<br /><br>as compared to healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>