The effects of recurrent hypoglycaemia on gastric emptying, glucose absorption, autonomic nerve function, cardiac function, glucagon, pancreatic polypeptide and catecholamine secretion.

Not Applicable

Completed

• Conditions: Diabetes; Recurrent Hypoglycemia; Gastric Emptying; Autonomic Nerve Function; Glucose Absorption; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12614000986673
• Lead Sponsor: Associate Professor Adam Deane

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-09-12
• Study Completion: 2016-02-16
• Last Update Posted: 5 July 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

Healthy lean (BMI 18-30) young men aged 18-35

Exclusion Criteria

Exclusion criteria will comprise:
*Radiation exposure for research purposes in the past 12 months;
*History of diabetes;
*HbA1c >6.0%;
*Impaired renal function;
*Creatinine clearance <100 ml/min;
*Hb <130 g/L
*Taking medication that are known to effect gastrointestinal motility;
*Taking medication effecting blood glucose;
*Previous surgery on the stomach or small intestine;
*History of autonomic neuropathy;
*Smoking >10 cigarettes per day;
*Alcohol >20g per day;
*History of cardiac disease ;
*History of cardiac arrhythmias;
*ECG abnormalities;
*Because of concerns of cumulative life time exposure to radiation, we will directly screen all volunteers as to their previous radiation exposure, and will exclude any volunteer who has received 3 or more examinations using a computerized tomogram and/or 10 or more examinations using standard x-rays.
*Previous surgery on the autonomic nervous system (eg sympathectomy)
*Previous surgery on the adrenal glands
*History of seizures or seizure disorders
*History of migranes

Study & Design

• Study Type: Interventional
• Study Design: Not specified