An investigation of particle production whilst using nasal high flow and a surgical mask in adult volunteers to inform the risk of infection to healthcare workers

Not Applicable

Conditions: Respiratory illness
Respiratory - Normal development and function of the respiratory system

Registration Number: ACTRN12622000357752

Lead Sponsor: niversity of Auckland

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 25

Inclusion Criteria

•Participants 18 years and over
•Capable of informed consent
•Neck size of 34-52 cm (appropriate to NIV hoods available)

Exclusion Criteria

•Diagnosis of COVID-19 within the last 4 weeks
•Current symptoms of respiratory illness or COVID-19
•Lung disease (e.g. > mild asthma, COPD, Bronchiectasis)
•Mask phobia / claustrophobia
•Conditions that are contraindicated by the manufacturer (Fisher & Paykel Healthcare) for using nasal high flow
•Direct reports of the principal investigator

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint is:<br>Particle number per unit time in the size range 1-5 um in gas expired from the participant measured using an optical particle counter. We will analyse data from the following activities (order to be randomised): 1) Normal breathing, 2) Speaking 3) Coughing at 0, 6, 60L.min-1 with and without a surgical mask with mouth open and closed as composite outcomes.<br>[ Each measurement will be taken for 1 minute.]

Secondary Outcome Measures

Name	Time	Method
Particle sizes and distribution in gas expired from the participant measured with an optical particle counter.[ Each measurement will be taken for 1 minute.];Total particle count per volume in gas expired from the participant measured with an optical particle counter.[ Each measurement will be taken for 1 minute.];Total particle count in gas expired from the participant measured with an optical particle counter.[ Each measurement will be taken for 1 minute.];Particle density in gas expired from the participant measured with an optical particle counter.[ Each measurement will be taken for 1 minute.];Tolerability as measured by the rate and reasons of withdrawal of participants. This will be recorded on the Case Report Form and the participant will be asked his/her reason for withdrawal.[ End of study]