In-Human CXCR4 Imaging of Hematologic and Solid Tumors Using [68Ga]-Pentixafor-PET

Phase 1

Recruiting

• Conditions: Non-Hodgkin Lymphoma; Multiple Myeloma; Histiocytic Neoplasms; Erdheim-Chester Disease; Rosai-Dorfman Disease

• Registration Number: NCT05093335
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-1
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br>Twenty patients with histologically proven treatment-naïve, therapy-refractory or<br>relapsed blood cancers meeting the below criteria will be included:<br><br> - Indolent B- or T-cell Non-Hodgkin lymphoma (including cutaneous lymphomas) or<br> Non-Hodgkin lymphoma with variable FDG uptake and clinical course, such as mantle<br> cell lymphoma; and measurable disease according to Lugano criteria<br><br>or<br><br> - Histiocytic neoplasms (Langerhans cell histiocytosis (LCH), Erdheim-Chester disease<br> (ECD) and/or Rosai-Dorfman disease (RDD)<br><br> - MGUS/SMM or MM according to IMWG definitions<br><br> - Solid tumors, such as lung cancers, meningioma, adrenocortical neoplasms including<br> cortisol-producing adenomas or high suspicion for tumor, such as in patients with<br> Cushing's disease.<br><br> - Age =18<br><br> - Negative serum pregnancy test for female volunteers of childbearing age and<br> potential (as defined by MSKCC Standards & Guidelines) from assays obtained <2 weeks<br> prior to study enrollment/intervention; or negative urine pregnancy test performed<br> on the day of intervention<br><br> - MSKCC patients<br><br>Exclusion Criteria:<br><br> - Breast-feeding<br><br> - History of renal functional disorders (chronic kidney disease with eGFR<30)<br><br> - Refusal or inability to tolerate the scanning procedure (e.g., due to<br> claustrophobia)

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Tumor standard uptake value (SUV)