Effects of citrulline on intestinal function during physical exercise

Completed

• Conditions: 10018031; decreased splanchnic circulation; splanchnic hypoperfusion

• Registration Number: NL-OMON34293
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

male
age 18-35 years
healthy

Exclusion Criteria

medical history includes abdominal surgery
use of alcohol, medication or drugs

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Key search parameters:<br /><br><br /><br>- GI perfusion: tonometry and sublingual sidestream dark field (SDF) imaging of<br /><br>perfusion<br /><br>- Intestinal damage: Plasma intestinal fatty acid binding protein (I-FABP) and<br /><br>analysis by video capsule</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Liver damage: plasma liver FABP (L-FABP), alanine and aspartate<br /><br>aminotransferase (ALT, AST)<br /><br>- Kidney damage: urinary N-acetyl-beta-(D)-glucosaminidase (NAG)<br /><br>- GI permeability: sugar in urine and plasma analysis<br /><br>- Amino acid analysis<br /><br>- Glycocalyxcomponents in plasma<br /><br>- Endotoxins and inflammatory markers in plasma</p><br>