Evaluation of the effects of Supplementation with L-Citrulline in patients with stomach and colorectal Cancer undergoing Chemotherapy

Not Applicable

• Conditions: Toxicity; D27.888; Antineoplastics

• Registration Number: RBR-4thrg35
• Lead Sponsor: niversidade Federal de Alfenas

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2023-03-10
• Study Start: 2023-04-10
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Patients aged 18 years or older; with a diagnosis of gastrointestinal cancer confirmed by biopsy and histological analysis; first neoplasm; under treatment for a maximum of 12 months; capable of supplementation by oral administration

Exclusion Criteria

Patients who had any chronic or acute condition that limited their ability to participate in the study; the inability to swallow; and refusal to sign the informed consent form

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate the potential of L-citrulline for mitigating the side effects of toxicity caused by chemotherapy treatment, after supplementation for 28 days, based on the comparison of biochemical tests performed at the beginning and end of supplementation. We also want to find differences between the intervention groups and the placebo control group.

Secondary Outcome Measures

Name	Time	Method
Evaluate the potential of L-citrulline on the mitigation of renal and hepatic toxicity through supplementation in dosages developed for this purpose compared to the beginning. It is also desired to find differences between the intervention groups with the placebo control.