Evaluation of the effectiveness of L-citrulline plus nCPAP versus solitary nCPAP in improvement of endothelium dysfunction and decreasing the severity of obstructive sleep apnea

Phase 3

Conditions: Obstructive sleep apnea/L-citruline effect on artery.
Obstructive sleep apnea (adult) (pediatric)
G47.33

Registration Number: IRCT20181126041757N1

Lead Sponsor: Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 42

Inclusion Criteria

Patients who are categorized as moderate to severe according to AHI criteria by using polysomnography
The ones that clinical ultrasonography proves that the patient has endothelial dysfunction (FMD> NMD)
Patients the their arterial muscular dysfunction has been ruled out

Exclusion Criteria

If less than 40 days have been passed from patien's OSA treatment
Hx of coronary artery disease (>50% of arterial occlusion, or any background PCI or CBAG)
Ischemic heart disease
Smoking
Patients who do not have endothelial dysfunction (FMD ratio to normal vessel diameter is more than one)
Receiving any medication that affects endothelial function unless 4 half-life of the drug has been passed since its last consume.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brachial artery diameter. Timepoint: The beginning and the end of the study. Method of measurement: colour doppler ultrasound.

Secondary Outcome Measures

Name	Time	Method
Daily sleepiness. Timepoint: at the beginning and the end of the study. Method of measurement: Epworth sleepness scale questionnaire.;Depression rate. Timepoint: The beginning and the end of the study. Method of measurement: patients health questionnaire-9.;Dislipidemia. Timepoint: The beginning and the end of the study. Method of measurement: Patient case.