Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study

Not Applicable

Completed

• Conditions: Sleep Deprivation; Healthy Volunteers; Skeletal Muscle
• Interventions: Behavioral: Normal sleep night; Behavioral: Sleepless night

• Registration Number: NCT03404427
• Lead Sponsor: Poitiers University Hospital

Brief Summary

The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.

During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.

The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.

Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.

Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.

Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-12
• Study First Submitted QC: 2018-01-12
• Study First Posted: 2018-01-19
• Study Start: 2019-02-14
• Primary Completion: 2020-03-04
• Study Completion: 2020-03-04
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-20
• Last Update Posted: 2020-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 21

Inclusion Criteria

• adult male volunteers;
• 25 to 45 years old
• regularly sleeping more than 6 hours per night;
• no excessive consumers of coffee (<3 espressos / day);
• absence of muscular or neurological pathology ;
• with a BMI> 18 and <25 kg / m²;
• Horne and Ostberg score> 31 and <69 ;

Exclusion Criteria

• female sex
• history of neuromuscular disease ;
• implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
• history of epilepsy, or discomfort after sleep deprivation ;
• poor sleepers (PSQI> 5);
• exercising an activity in staggered hours;
• regularly performing more than 2 nights without sleep per month;
• taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
• having crossed 4 time zones in the previous 4 weeks.
• current participation in another clinical research study;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Normal sleep night	Normal sleep night	The first endurance test is the endurance motor control test after a normal sleep night.
Sleepless night	Sleepless night	The first endurance test is the endurance motor test after a sleepless night.

Primary Outcome Measures

Name	Time	Method
Test duration	1 hour.	Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds.

Trial Locations

Locations (1)

Centre Hospitalier de Poitiers; 🇫🇷 Poitiers, Vienne, France