Effects of Sleep Privation on Sensorimotor Integration of the Upper Limb During a Manual Endurance Test in Healthy Volunteers-Physiological Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Test duration
研究概览
简要总结
The investigator showed that a night of sleep deprivation halved the duration of an inspiratory endurance test and that this loss of endurance could be secondary to a lack of activation of the pre-motor cortex. However, the inspiratory endurance test is associated with a feeling of dyspnea that could lead to premature arrest, and the inspiratory drive is complex, both automatic and voluntary. The investigator can reproduce this results on a simpler drive.
During the execution of an exercise involving repeated contractions of the hand it is possible to record the activation of the pre-motor cortex corresponding to the phase of preparation of the movement. The amplitude of these premotor potentials is proportional to the developed motive force.
The purpose of this study is to assess the impact of sleep deprivation on the muscular endurance of non-dominant in healthy subjects.
Hypothesis: Sleep deprivation causes a decrease in manual motor endurance by decreasing cortical pre-motor control.
Main objective: To compare the motor endurance of healthy subjects after a night's sleep and after a sleepless night.
Secondary objective: To compare the amplitude of premature cortical control at the beginning of the endurance test after a night's sleep and after a sleepless night.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
盲法说明
When analyzing the results (endurance, magnitude of the premotor potential), the outcomes assessor will not know if it is a normal night or a sleepless night
入排标准
- 年龄范围
- 25 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •adult male volunteers;
- •25 to 45 years old
- •regularly sleeping more than 6 hours per night;
- •no excessive consumers of coffee (<3 espressos / day);
- •absence of muscular or neurological pathology ;
- •with a BMI> 18 and <25 kg / m²;
- •Horne and Ostberg score> 31 and <69 ;
排除标准
- •female sex
- •history of neuromuscular disease ;
- •implanted metallic or electronic equipment (vascular stent, ocular implant, pacemaker ...)
- •history of epilepsy, or discomfort after sleep deprivation ;
- •poor sleepers (PSQI> 5);
- •exercising an activity in staggered hours;
- •regularly performing more than 2 nights without sleep per month;
- •taking drugs interfering with sleep (antidepressants, benzodiazepines ...);
- •having crossed 4 time zones in the previous 4 weeks.
- •current participation in another clinical research study;
研究组 & 干预措施
Normal sleep night
The first endurance test is the endurance motor control test after a normal sleep night.
干预措施: Normal sleep night (Behavioral)
Sleepless night
The first endurance test is the endurance motor test after a sleepless night.
干预措施: Sleepless night (Behavioral)
结局指标
主要结局
Test duration
时间窗: 1 hour.
Time, in minutes, measured between the beginning of the endurance test and the end of the test, defined by the volunteer's inability to maintain a force of at least 30% of the maximum strength for 5 seconds.
次要结局
未报告次要终点