Effects of sleep deprivation on neurobehavioural and physiological variables in patients with respiratory disorders and healthy controls.

Woolcock Institute of Medical Research0 sites40 target enrollmentAugust 5, 2005

Overview

No summary available.

Registry

who.int

Start Date

August 5, 2005

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

•OSA: Untreated subjects with moderate to severe OSA (RDI \> 30\).
•Asthma: Asthmatic subjects (ATS Criteria) will be recruited from asthma clinics associated with AIs. We will use clinic patients (current non\-smokers and minimal smoking history)with moderate to severe asthma based on NAC guidelines i.e. those requiring short acting beta agonists 3 or more days week or with nocturnal symptoms more than once per fortnight.
•Controls: We will recruit healthy controls.

•OSA: use of alcohol\> 40gm/day, psychotropic medication, intercurrent asthma, other unstable medical conditions or evidence of clinically significant awake respiratory failure.
•Asthma:We will exclude subjects on long\-acting bronchodilators (salmeterol, formoterol, tiotropium and theophylline). Inhaled corticosteroids will be held constant from screening into studies and use of short acting beta agonists will be permitted and monitored during protocols.
•Controls: similar exclusion criteria as for the OSA and asthma subjects
•Subjects with the presence of asthma (ATS criteria) and OSA will be excluded. The absence of OSA will be determined using a validated nocturnal respiratory monitor over 2 nights (Autoset T, ResMed).