nderstanding sleep deprivation effects on cognitive performance through comprehensive characterizatio

Completed

Conditions: cognitieve prestatie(verlies) door slaapdeprivatie
cognitive resilience

Registration Number: NL-OMON49165

Lead Sponsor: TNO

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

1. The potential participant has given informed and written consent and is able
to comply with all study assessments scheduled in the protocol.
2. All subjects need to be between 18 and 55 years of age.
3. All subjects has computer skills.
4. All subjects need to be in good health, and may not have any chronic
diseases.
5. BMI between 18 and 30 kg/m2.
6. No alcohol the day before the start of a test day.
7. No drugs used in the last 3 months.
8. Subjects must be able to communicate, participate, and comply with the
requirements of the entire study.
9. One week prior to starting every trial day, all subjects need to be (and
remain) in the same time zone as the CET time zone in which the research center
lies. (GMT+1, daylight savings GMT+2). This to exclude jet lags that might
confound the test results.
10. No signs of flue or viral infection in the last 10 days before the start.

Exclusion Criteria

1. Smoking
2. Pregnant
3. A history of psychiatric illness; this including sleeping disorders.
4. Autoimmune disease and/or hyperactive thyroid
5. People with known heart, kidney or liver disease or neurological complaints.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters/endpoints are inflammatory responses. These will be<br /><br>assessed using capillary blood samples obtained from finger pricks.<br /><br><br /><br>The main primary endpoints of cognitive resilience will be defined as the<br /><br>difference between cognitive performance measures before and after the night.<br /><br>Cognitive resilience to SD refers to the extent to which a sleep deprived<br /><br>individual maintains cognitive performance while sleep deprived.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Cognitive performance determined based on the PVT<br /><br>- HR and EDA during Psychological Synchrony<br /><br>- Stanford Sleepiness Scale (SSS)<br /><br>- Rating Scale of Mental Effort (RSME)</p><br>