A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke

Phase 3

Terminated

• Conditions: Prevention of Stroke or Systemic Embolism; Atrial Fibrillation
• Interventions: Drug: Asundexian (BAY2433334); Drug: Apixaban; Drug: Apixaban matching placebo; Drug: Asundexian matching placebo

• Registration Number: NCT05643573
• Lead Sponsor: Bayer

Brief Summary

Researchers are looking for a better way to treat people with atrial fibrillation (AF) and prevent stroke or systemic embolism (blood clots travelling through the blood stream to plug another vessel).

Atrial fibrillation is a condition of having irregular and often rapid heartbeat. It can lead to the formation of blood clots in the heart which can travel through the blood stream to plug another vessel, and like this lead to serious and life-threatening conditions, such as a stroke. A stroke occurs because the brain tissue beyond the blockage no longer receives nutrients and oxygen so that brain cells die. As strokes arising from atrial fibrillation can involve extensive areas of the brain, it is important to prevent them.

Blood clots are formed in a process known as coagulation. Medications are already available to prevent the formation of blood clots. When taken by mouth (orally), they are known as oral anticoagulants (OACs) including apixaban. OACs decrease the risk of the above-mentioned serious and life-threatening conditions. The main side effect of OACs is an increase of the risk of bleeding.

The study treatment asundexian is a new type of anticoagulant currently under development to provide further treatment options. Asundexian aims to further improve the standard of care with regard to the risk of bleeding.

The main purpose of this study is to collect more data about how well asundexian works to prevent stroke and systemic embolism and how safe it is compared to apixaban in people with atrial fibrillation and at high risk for stroke.

To see how well the study treatment asundexian works researchers compare:

* how long asundexian works well and

* how long apixaban works well after the start of the treatment. Working well means that the treatments can prevent the following from happening:

* stroke and/or

* systemic embolism. The study will keep collecting data until a certain number of strokes or embolisms happen in the study.

To see how safe asundexian is, the researchers will compare how often major bleedings occur after taking the study treatments asundexian and apixaban, respectively. Major bleedings are bleedings that have a serious or even life-threatening impact on a person's health.

The study participants will be randomly (by chance) assigned to 1 of 2 treatment groups, A and B. Dependent on the treatment group, the participants will either take the study treatment asundexian by mouth once a day or apixaban by mouth twice a day for approximately 9 - 33 months.

Each participant will be in the study for approximately 9 - 34 months. There will be visits to the study site every 3 to 6 months and up to 7 phone calls. Those participants who do not want or are unable to have visits to the study site may join the study remotely in selected locations. The location name contains the abbreviation - DCT in such cases.

During the study, the study team will:

* take blood samples

* do physical examinations

* examine heart health using an electrocardiogram (ECG)

* check vital signs such as blood pressure and heart rate

* do pregnancy tests

* ask the participants questions about their quality of life

* ask the participants questions about how they are feeling and what adverse events they are having.

An adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events that happen in studies, even if they do not think the adverse events might be related to the study treatments.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-11-30
• Study First Submitted QC: 2022-11-30
• Study Start: 2022-12-05
• Study First Posted: 2022-12-08
• Primary Completion: 2024-01-31
• Study Completion: 2024-01-31
• Results First Submitted: 2024-10-17
• Status Verified: 2024-12
• Results First Submitted QC: 2024-12-04
• Last Update Submitted: 2024-12-04
• Results First Posted: 2024-12-09
• Last Update Posted: 2024-12-09

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 14830

Inclusion Criteria

• 18 years of age or older

• The patient willing and able to understand the Patient information Sheet and provide written informed consent

• Atrial fibrillation with an indication for indefinite treatment with an oral anticoagulant

• CHA2DS2-VASc score ≥ 3 if male or ≥ 4 if female, OR CHA2DS2-VASc score of 2 if male or 3 if female and at least one of the following enrichment criteria:

  • age ≥ 70
  • previous stroke, transient ischemic attack, or systemic embolism
  • renal dysfunction with eGFR < 50 ml/min within 14 days prior to randomization
  • prior episode of non-traumatic major bleeding
  • current single agent antiplatelet therapy planned to continue for at least 6 months after randomization
  • ≤ 6 consecutive weeks of treatment with oral anticoagulant prior to randomization.

Exclusion Criteria

• Mechanical heart valve prosthesis

• Moderate-to-severe mitral stenosis at the time of study inclusion.

• Atrial fibrillation only due to reversible cause.

• Participants after successful ablation therapy without documented recurrent AF or participants after left atrial appendage occlusion / exclusion or plan for ablation or Left atrial appendage (LAA) occlusion / exclusion within the next 6 months.

• Recent ischemic stroke (within 7 days prior to randomization).

• Active non-trivial bleeding; known chronic bleeding disorder ; history of non-traumatic intracranial hemorrhage.

• Known significant liver disease or known hepatic insufficiency classified as Child-Pugh B or C at randomization.

• Estimated glomerular filtration rate (eGFR) < 25 mL/min/1.73 m2 within 14 days prior to randomization or on dialysis or expected to be started on dialysis within the next 12 months starting from randomization.

• Major surgery during the last 30 days prior to randomization.

• Known allergy, intolerance or hypersensitivity to either of the study interventions.

• Any contraindication for the use of an anticoagulant or listed in the local labelling for apixaban.

• Requirement for chronic anticoagulation for a different indication than AF, e.g. mechanical heart valve or left ventricular cardiac thrombus (atrial thrombus is allowed), or dual antiplatelet therapy (single agent therapy is allowed).

• Treatment with Vitamin K antagonist (VKA) in the 10 days prior to randomization.

• Concomitant use of or anticipated need for:

  • daily or near daily (> 5 days per week) therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) for more than 4 weeks during the study
  • herbal or traditional medicine, and / or supplements with known anticoagulant and / or antiplatelet effect
  • combined P-glycoprotein (P-gp) and strong cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors
  • combined P-gp and strong / moderate CYP3A4 inducers Respective substances (apart from NSAIDs) must be stopped - in case of combined inhibitors / inducers of CYP3A4 and P-gp for at least 14 days before randomization.

• Previous (within 30 days or 5 half-lives of the investigational drug, whichever is longer) or concomitant participation in another clinical study with investigational medicinal product(s) or device(s). Registries and observational studies are allowed.

• Known current alcohol and / or illicit drug abuse.

• Close affiliation with the investigational site.

• Any other history, condition or therapy, or uncontrolled intercurrent illness which would make the participant unsuitable for the study vulnerable or life expectancy < 12 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Asundexian	Apixaban matching placebo	Participants will receive asundexian and apixaban matching placebo.
Asundexian	Asundexian (BAY2433334)	Participants will receive asundexian and apixaban matching placebo.
Apixaban	Asundexian matching placebo	Participants will receive apixaban and asundexian matching placebo.
Apixaban	Apixaban	Participants will receive apixaban and asundexian matching placebo.

Primary Outcome Measures

Name	Time	Method
Number of Participants With Composite of Stroke or Systemic Embolism	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; Stroke was defined as an acute episode of focal or global neurological dysfunction caused by an injury of the brain, spinal cord, or retina as a result of hemorrhage or infarction.; Systemic embolism is defined as abrupt vascular insufficiency associated with clinical or radiological evidence of arterial occlusion in the absence of other likely mechanisms (this does not include myocardial infarction, thromboembolism of the pulmonary vasculature or venous thrombosis, e.g. pulmonary embolism or deep venous thrombosis).
Number of Participants With International Society on Thrombosis and Hemostasis (ISTH) Major Bleeding	Approximately 12 months	Assessment based on the (csHR), comparing asundexian with apixaban which is based on time to first event.; ISTH Major Bleeding was defined as an event that meets at least one of the below criteria, based on the definition given by the ISTH (Schulman and Kearon 2005): * Fatal bleeding, and/or; * Symptomatic bleeding in a critical area or organ (intracranial, intraspinal, intraocular with compromised vision, pericardial, retroperitoneal, intra-articular, or intramuscular with compartment syndrome), and/or; * Clinically overt\* bleeding associated with a recent (within 48 hours) decrease in the hemoglobin level of ≥ 2 g/dL (20 g/L; 1.24 mmol/L) compared with the most recent hemoglobin value available before the event, and/or; * Clinically overt\* bleeding leading to transfusion of 2 or more units of packed red blood cells or whole blood.; * Overt bleeding required the identification of the bleeding location and the hemoglobin drop and/or transfusion needed to be related to the bleeding.
Number of Participants With Composite of Stroke, Systemic Embolism, or ISTH Major Bleeding	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.

Secondary Outcome Measures

Name	Time	Method
Number of Participants With Composite of Disabling Stroke (mRS ≥ 3), Critical Bleeding, or All-cause Mortality	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; Critical bleeding was defined as symptomatic bleeding in either of the following critical locations (intracranial, intraspinal, pericardial, intra-articular, or retroperitoneal) or as intraocular bleeding with compromised vision or intramuscular bleeding with compartment syndrome.
Number of Participants With Clinically Relevant Non-major Bleeding	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Number of Participants With Hemorrhagic Stroke	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; Hemorrhagic stroke was defined as an acute, atraumatic extravasation of blood into the brain parenchyma, intraventricular or subarachnoid space with associated neurological symptoms. This does not include microbleeds or hemorrhagic transformation of an ischemic stroke.
Number of Participants With Intracranial Hemorrhage	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Number of Participants With Composite of Ischemic Stroke or Systemic Embolism	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; An ischemic stroke was defined as the rapid onset (or present on awakening) of a new focal neurological deficit with clinical (\> 24 hours symptoms / signs) or imaging evidence of infarction that is not attributable to a non-ischemic cause (i.e. not associated with infection, tumor, seizure, severe metabolic disease).
Number of Participants With All-cause Mortality	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Number of Participants With Ischemic Stroke	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; An ischemic stroke was defined as the rapid onset (or present on awakening) of a new focal neurological deficit with clinical (\> 24 hours symptoms / signs) or imaging evidence of infarction that is not attributable to a non-ischemic cause (i.e. not associated with infection, tumor, seizure, severe metabolic disease).
Number of Participants With Cardiovascular (CV) Death	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; CV death included death due to stroke, myocardial infarction, heart failure or cardiogenic shock, sudden death or any other death due to other cardiovascular causes or CV procedures. In addition, death due to non-traumatic cardiovascular hemorrhage will be included, e.g. non-stroke intracranial hemorrhage, non-procedural or non-traumatic vascular rupture (e.g. aortic aneurysm), or hemorrhage causing cardiac tamponade
Number of Participants With Composite of CV Death, Stroke, or Myocardial Infarction (MI)	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; The diagnosis of MI requires the combination of: * Presence of acute myocardial injury (changes in cardiac biomarkers) and; * Evidence of acute myocardial ischemia derived from the clinical presentation, electrocardiographic changes, or the results of myocardial or coronary artery imaging, or in case of post mortem pathological findings irrespective of biomarker values.
Number of Participants With Composite of ISTH Major or Clinically Relevant Non-major Bleeding	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; Clinically relevant non-major bleeding was considered any sign or symptom of acute or sub-acute clinically overt bleeding that does not fit the criteria for the ISTH definition of major bleeding, but does meet at least one of the following criteria (based on criteria published by the EMA) (EMA 2014): * requiring medical or surgical treatment by a healthcare professional for bleeding; * leading to hospitalization or increased level of care for bleeding; * a change in antithrombotic therapy (including study intervention) for bleeding \*Overt bleeding required the identification of the bleeding location.
Number of Participants With Fatal Bleeding	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.
Number of Participants With Minor Bleeding	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.; All other overt bleeding episodes not meeting the criteria for ISTH major or clinically relevant non-major bleeding were classified as minor bleeding (for example, bleeding from a minor wound that does not prompt a treatment for the bleeding, for instance with surgical hemostasis, or epistaxis that does not require a medical treatment for bleeding or a change in antithrombotic therapy).
Number of Participants With Composite of Stroke, Systemic Embolism, ISTH Major Bleeding, or All-cause Mortality	Approximately 12 months	The assessment was based on the cause-specific hazard ratio (csHR), comparing asundexian with apixaban which is based on time to first event.

Trial Locations

Locations (1069)

Hwa Mei Hospital, University of Chinese Academy Sciences; 🇨🇳 Ningbo, Zhejiang, China

Xuanwu Hospital Capital Medical University; 🇨🇳 Beijing, China

Beijing Tongren Hospital, Capital Medical University (West); 🇨🇳 Beijing, China

Cevni Kulatak; 🇨🇿 Praha, Hlavní Mesto Praha, Czechia

Benedor s.r.o.; 🇨🇿 Ostrava - Poruba, Moravskoslezský Kraj, Czechia

Vojenska nemocnice Brno; 🇨🇿 Brno, Czechia

Kardiologicka ambulance Cormedico; 🇨🇿 Bruntal, Czechia

Nemocnice Ceske Budejovice, a.s. Department of kardiologie; 🇨🇿 Ceske Budejovice, Czechia

Mrozek kardiologie; 🇨🇿 Frydek-Mistek, Czechia

Fakultni nemocnice v Motole; 🇨🇿 Praha 5, Czechia

Medicon Poliklinika Holesovice; 🇨🇿 Praha, Czechia

Päijät-Hämeen keskussairaala; 🇫🇮 Lahti, Finland

Hôpital Louis Pradel - Bron; 🇫🇷 Bron Cedex, France

Dr Signe Alliksoo Family Doctors Practice; 🇪🇪 Tallinn, Estonia

Office of Arvo Rosenthal; 🇪🇪 Tallinn, Estonia

StudyCor Oy; 🇫🇮 Jyvaskyla, Finland

Health Step Finland Oy; 🇫🇮 Kuopio, Finland

Oulun yliopistollinen sairaala; 🇫🇮 Oulu, Finland

Terveystalo Pulssi; 🇫🇮 Turku, Finland

Turun yliopistollinen keskussairaala; 🇫🇮 Turku, Finland

Centre Hospitalier Universitaire - Angers; 🇫🇷 Angers, France

Centre Hospitalier Intercommunal de la Côte Basque-Bayonne; 🇫🇷 Bayonne, France

Hôpital Trousseau - Tours; 🇫🇷 Chambray-lès-Tours, France

Hôpital Henri Mondor; 🇫🇷 Creteil, France

Centre Hospitalier Louis Pasteur; 🇫🇷 Le Coudray, France

Centre Hospitalier du Docteur Schnaffer - Lens; 🇫🇷 Lens, France

Hôpital Arnaud de Villeneuve - Montpellier; 🇫🇷 Montpellier, France

Hôpital Dupuytren; 🇫🇷 Limoges Cedex, France

Hôpital Guillaume et René Laennec - Nantes; 🇫🇷 Nantes, France

Hopital Carémeau - Nîmes; 🇫🇷 Nîmes, France

Hopital Européen Georges Pompidou - Paris; 🇫🇷 Paris Cedex 15, France

Institut Mutualiste Montsouris; 🇫🇷 Paris, France

Hôpital Cardiologique - Pessac; 🇫🇷 Pessac, France

CHU Rennes, H Pontchaillou, Cardiologie; 🇫🇷 Rennes, France

Centre Hospitalier Régional - Saint Brieuc; 🇫🇷 Saint Brieuc, France

Hôpital Civil - Strasbourg; 🇫🇷 Strasbourg, France

Centre de Cardiologie Nord - Saint Denis; 🇫🇷 Saint Denis, France

Universitaets Herzzentrum Bad Krozingen; 🇩🇪 Bad Krozingen, Baden-Württemberg, Germany

MEDICLIN Herzzentrum Lahr|Kardiologie; 🇩🇪 Lahr, Baden-Württemberg, Germany

Klinikum Fulda gAG|Medizinische Klinik I; 🇩🇪 Fulda, Hessen, Germany

UniKlinikum Aachen|Kardio, Angio, Intensivmedizin; 🇩🇪 Aachen, Nordrhein-Westfalen, Germany

Ev. Krankenhaus Hagen-Haspe|Kardiologie und Rhythmologie; 🇩🇪 Hagen, Nordrhein-Westfalen, Germany

St. Vinzenz-Hospital|Innere Medizin III, Kardiologie; 🇩🇪 Koeln, Nordrhein-Westfalen, Germany

Klinikum Lüdenscheid - Märkische Kliniken GmbH; 🇩🇪 Lüdenscheid, Nordrhein-Westfalen, Germany

Sana-Klinikum Remscheid|Kardio, Angio, Pneumo u. Intensivmed; 🇩🇪 Remscheid, Nordrhein-Westfalen, Germany

Forschungszentrum Ruhr KliFoCenter GmbH; 🇩🇪 Witten, Nordrhein-Westfalen, Germany

Universitätsmedizin der Johannes Gutenberg Universität Mainz; 🇩🇪 Mainz, Rheinland-Pfalz, Germany

Krankenhaus Dresden-Friedrichstadt; 🇩🇪 Dresden, Sachsen, Germany

Uniklinik Leipzig / Kardiologie; 🇩🇪 Leipzig, Sachsen, Germany

Praxisklinik Herz und Gefaesse|Kardiologische Ambulanz; 🇩🇪 Dresden, Sachsen, Germany

Praxis Hr. Dr. med. Jens Taggeselle; 🇩🇪 Markkleeberg, Sachsen, Germany

Klinische Forschung Hamburg GmbH; 🇩🇪 Hamburg, Germany

Kardiologische Praxis Hr. Dr. A. Al-Zoebi; 🇩🇪 Wermsdorf, Sachsen, Germany

Uniklinik Jena / Kardiologie; 🇩🇪 Jena, Thüringen, Germany

Uniklinikum Hamburg-Eppendorf|Klinik für Kardiologie; 🇩🇪 Hamburg, Germany

Cardiologicum Hamburg; 🇩🇪 Hamburg, Germany

HIPPOKRATION General Hospital of Athens; 🇬🇷 Athens, Greece

General Hospital of Athens "ALEXANDRA"; 🇬🇷 Athens, Greece

G. GENNIMATAS General State Hospital of Athens; 🇬🇷 Athens, Greece

University General Hospital of Athens "ATTIKON"; 🇬🇷 Chaidari, Greece

University General Hospital of Heraklion; 🇬🇷 Heraklion, Greece

University General Hospital of Ioannina; 🇬🇷 Ioannina, Greece

University General Hospital of Larissa; 🇬🇷 Larissa, Greece

AHEPA University General Hospital of Thessaloniki; 🇬🇷 Thessaloniki, Greece

General Hospital ASKLEPIEIO VOULAS; 🇬🇷 Voula, Greece

Budapesti Uzsoki Utcai Korhaz; 🇭🇺 Budapest, Hungary

Belinus Bt.; 🇭🇺 Debrecen, Hungary

Somogy Varmegyei Kaposi Mor Oktato Korhaz; 🇭🇺 Kaposvar, Hungary

Nagykanizsai Kanizsai Dorottya Korhaz; 🇭🇺 Nagykanizsa, Hungary

Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft.; 🇭🇺 Nyiregyhaza, Hungary

Borbanya Praxis Bt.; 🇭🇺 Nyiregyhaza, Hungary

Dr. Laszlo Elek Korhaz es Rendelointezet, Oroshaza; 🇭🇺 Oroshaza, Hungary

Pecsi Tudomanyegyetem Klinikai Kozpont; 🇭🇺 Pecs, Hungary

Tolna Varmegyei Balassa Janos Korhaz; 🇭🇺 Szekszárd, Hungary

Lisie Hospital; 🇮🇳 Kochi, Kerala, India

Vijan Cardiac & Critical Care Centre; 🇮🇳 Nashik, Maharashtra, India

Asian Institute of Gastroenterology (AIG Hospital); 🇮🇳 Hyderabad, India

Barzilai Ashkelon University Medical Center | Cardiology Department; 🇮🇱 Ashkelon, Israel

Clalit Health | Soroka Medical Center - Cardiology Department; 🇮🇱 Beer Sheva, Israel

Galilee Medical Center | Cardiology Department; 🇮🇱 Nahariya, Israel

Kaplan Medical Center | Cardiology Department - Heart Institute Research; 🇮🇱 Rehovot, Israel

Shamir Medical Center | Cardiology Department; 🇮🇱 Rishon LeZion, Israel

Tel Aviv Sourasky Medical Center | Ichilov General Hospital - Cardiology Department; 🇮🇱 Tel Aviv, Israel

Tel-Aviv Sourasky Medical Center; 🇮🇱 Tel Aviv, Israel

Ziv Medical Center | Cardiology Department; 🇮🇱 Zefat, Israel

ASL2 Lanciano-Vasto-Chieti; 🇮🇹 Chieti, Abruzzo, Italy

A.O Sant'Anna-San Sebastiano; 🇮🇹 Caserta, Campania, Italy

A.O.U. Policlinico Federico II Napoli; 🇮🇹 Naples, Campania, Italy

A.O.R.N. Ospedali dei Colli (Monaldi-Cotugno-CTO); 🇮🇹 Napoli, Campania, Italy

Azienda Unita Sanitaria Locale Di Bologna_Ospedale Maggiore Pizzardi - Cardiologia; 🇮🇹 Bologna, Emilia-Romagna, Italy

A.O.U. di Ferrara; 🇮🇹 Ferrara, Emilia-Romagna, Italy

A.O.U. di Modena - Policlinico; 🇮🇹 Modena, Emilia-Romagna, Italy

A.O.U. di Parma; 🇮🇹 Parma, Emilia-Romagna, Italy

ASST Papa Giovanni XXIII; 🇮🇹 Bergamo, Lombardia, Italy

ASST del Garda; 🇮🇹 Brescia, Lombardia, Italy

Ospedale San Raffaele s.r.l. - Cardiologia Clinica; 🇮🇹 Milano, Lombardia, Italy

IRCCS Centro Cardiologico Monzino; 🇮🇹 Milano, Lombardia, Italy

ASST Sette Laghi; 🇮🇹 Varese, Lombardia, Italy

A.O.U. Ospedali Riuniti "Umberto I - G.M.Lancisi - G.Salesi"; 🇮🇹 Ancona, Marche, Italy

ASUR Marche - Area Vasta 5; 🇮🇹 Ascoli Piceno, Marche, Italy

A.O.U. Maggiore della Carità; 🇮🇹 Novara, Piemonte, Italy

A.O.U. Ospedali Riuniti Foggia; 🇮🇹 Foggia, Puglia, Italy

A.O.U. Policlinico G. Martino; 🇮🇹 Messina, Sicilia, Italy

AUSL Toscana Sud-Est; 🇮🇹 Arezzo, Toscana, Italy

A.O.U. Careggi; 🇮🇹 Firenze, Toscana, Italy

A.O.U. Pisana; 🇮🇹 Pisa, Toscana, Italy

ULSS2 Marca Trevigiana; 🇮🇹 Treviso, Veneto, Italy

ULSS3 Serenissima; 🇮🇹 Venezia, Veneto, Italy

Japan Community Healthcare. Organization Chukyo Hospital; 🇯🇵 Nagoya, Aichi, Japan

Japanese RedCross Aichi Medical Center Nagoya Daini Hospital; 🇯🇵 Nagoya, Aichi, Japan

Kimitsu Chuo Hospital; 🇯🇵 Kisarazu, Chiba, Japan

Matsuyama Shimin Hospital; 🇯🇵 Matsuyama, Ehime, Japan

Fukuoka Shinmizumaki Hospital | Clinical Trial Management Office; 🇯🇵 Tateyashiki, Mizumakimachi, On, Fukuoka-ken, Japan

Kokura Memorial Hospital; 🇯🇵 Kitakyushu, Fukuoka, Japan

Steel Memorial Yawata Hospital; 🇯🇵 Kitakyusyu, Fukuoka, Japan

Go Neurosurgical Clinic; 🇯🇵 Nakagawa, Fukuoka, Japan

Onga Nakama Medical Association Onga Hospital; 🇯🇵 Onga-gun, Fukuoka, Japan

Yanagawa Hospital; 🇯🇵 Yanagawa-city, Fukuoka, Japan

Asahikawa City Hospital; 🇯🇵 Asahikawa, Hokkaido, Japan

Hakodate National Hospital; 🇯🇵 Hakodate, Hokkaido, Japan

Matsuda Cardiovascular clinic; 🇯🇵 Sapporo, Hokkaido, Japan

Teine Keijinkai Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

Sapporo Higashi Tokushukai Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

The Veritas Hospital; 🇯🇵 Kawanishi, Hyogo, Japan

Ibaraki Prefectural Central Hospital; 🇯🇵 Kasama, Ibaraki, Japan

Kanazawa Medical University Hospital; 🇯🇵 Kahoku-gun, Ishikawa, Japan

Ishikawa Prefectural Central Hospital; 🇯🇵 Kanazawa, Ishikawa, Japan

National Hospital Organization Kanazawa Medical Center | Clinical Trial Management Office; 🇯🇵 Kanazawa, Ishikawa, Japan

Komatsu Municipal Hospital; 🇯🇵 Komatsu, Ishikawa, Japan

Kagawa Prefectural Central Hospital; 🇯🇵 Takamatsu, Kagawa, Japan

Oosumikanoya Hospital; 🇯🇵 Kanoya, Kagoshima, Japan

Yokohama City University Medical Center; 🇯🇵 Yokohama, Kanagawa, Japan

Yokohama Sakae Kyosai Hospital; 🇯🇵 Yokohama, Kanagawa, Japan

Japan Culture and Welfare Federation of Agricultural Cooperatives | Suzuka Chuo General Hospital; 🇯🇵 Suzuka-shi, Mie, Japan

Tohoku Medical and Pharmaceutical University Hospital | Center for Clinical Research Promotion and Development; 🇯🇵 Sendai-city, Miyagi-ken, Japan

Sendai Cardiovascular Center; 🇯🇵 Sendai, Miyagi, Japan

Japan Red Cross Society Azumino Hospital; 🇯🇵 Azumino, Nagano, Japan

Fukuoka University Nishijin Hospital; 🇯🇵 Fukuoka, Japan

Miyazaki Medical Association Hospital; 🇯🇵 Miyazaki, Japan

Oita Prefectural Hospital; 🇯🇵 Oita, Japan

Kyungpook National University Hospital; 🇰🇷 Daegu, Daegu Gwang''yeogsi, Korea, Republic of

The Catholic University of Korea Seoul St. Mary's Hospital; 🇰🇷 Seoul, Gyeonggido, Korea, Republic of

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeonggido, Korea, Republic of

The Catholic Univ. of Korea Eunpyeong St. Mary's Hospital; 🇰🇷 Seoul, Seoul Teugbyeolsi, Korea, Republic of

Chonnam National University Hospital; 🇰🇷 Gwangju, Korea, Republic of

Medisch Spectrum Twente | Thorax Centrum Twente - Foundation Cardiovascular Research and Education Enschede; 🇳🇱 Enschede, Netherlands

Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica; 🇵🇹 Lisboa, Portugal

Centro Hospitalar Universitario de Sao Joao | Polo Porto - Centro de Investigacao e Ensaios Clinicos; 🇵🇹 Porto, Portugal

Centro Hospitalar De Tras os Montes e Alto Douro | Hospital Sao Pedro - Centro de Investigacao Clinica; 🇵🇹 Vila Real, Portugal

Cardiomed S.R.L; 🇷🇴 Cluj-Napoca, Dolj, Romania

CMI. Dr. Podoleanu Cristian; 🇷🇴 Targu Mures, Mures, Romania

Municipal Clinical Emergency Hospital of Timisoara; 🇷🇴 Timisoara, Timis, Romania

Sp. Judetean de Urgenta Dr. Constantin Opris Baia Mare; 🇷🇴 Baia Mare, Romania

Spitalul Clinic de Urgenta Sf. Ioan; 🇷🇴 Bucharest, Romania

Spitalul Clinic Colentina; 🇷🇴 Bucuresti, Romania

Spitalul Clinic de Recuperare Cluj-Napoca; 🇷🇴 Cluj Napoca, Romania

Sfantul Spiridon Emergency Clinical County Hospital; 🇷🇴 Iasi, Romania

S.C. CARDIOMED S.R.L. Iasi; 🇷🇴 Iasi, Romania

S.C. Sal Med SRL; 🇷🇴 Pitesti, Romania

Spitalul Judetean de Urgenta Satu Mare; 🇷🇴 Satu Mare, Romania

National Heart Centre Singapore; 🇸🇬 Singapore, Singapore

SingHealth Polyclinics - Pasir Ris; 🇸🇬 Singapore, Singapore

Changi General Hospital; 🇸🇬 Singapore, Singapore

Sengkang General Hospital; 🇸🇬 Singapore, Singapore

Northwestern University; 🇺🇸 Chicago, Illinois, United States

Nemocnica s poliklinikou Brezno, n.o.; 🇸🇰 Brezno, Slovakia

KARDIO-ANGIO s.r.o.; 🇸🇰 Levice, Slovakia

ORALEK, s.r.o.; 🇸🇰 Namestovo, Slovakia

Specializovana nemocnica sv. Svorada Zobor, n.o.; 🇸🇰 Nitra, Slovakia

Kardiocentrum Nitra | Cardiology Clinic - Outpatient Department; 🇸🇰 Nitra, Slovakia

Medikard | Department of Internal Medicine; 🇸🇰 Presov, Slovakia

KaCH, s.r.o.; 🇸🇰 Nove Zamky, Slovakia

Medivasa s.r.o.; 🇸🇰 Zilina, Slovakia

Complejo Hospitalario Universitario de Ferrol | Hospital Naval - Unidad de Hipertensión Arterial; 🇪🇸 Ferrol, A Coruña, Spain

Hospital Clinico Universitario de Santiago de Compostela | Cardiology Department; 🇪🇸 Santiago de Compostela, A Coruña, Spain

Hospital Universitario Central de Asturias | Servicio de Cardiologia; 🇪🇸 Oviedo, Asturias, Spain

Jose Manuel Pascual Pascual S.A. | Hospital Virgen de las Montanas - Internal Medicine Department; 🇪🇸 Villamartin, Cádiz, Spain

Hospital Universitario de La Princesa | Internal Medicine Department; 🇪🇸 Madrid, Madrid [es-m], Spain

Hospital Alta Resolucion de Utrera | Cardiology Service Department; 🇪🇸 Utrera, Sevilla, Spain

University Hospital of A Coruna | Cardiology department; 🇪🇸 A Coruña, Spain

Hospital General Universitario Doctor Balmis de Alicante | Cardiology Department; 🇪🇸 Alicante, Spain

Hospital Universitario Ramon y Cajal | Departamento de Medicina Interna; 🇪🇸 Madrid, Spain

Hospital Universitario 12 de Octubre | Cardiology Department; 🇪🇸 Madrid, Spain

Falu Lasarett; 🇸🇪 Falun, Sweden

Södra Älvsborgs Sjukhus; 🇸🇪 Borås, Sweden

Vrinnevisjukhuset; 🇸🇪 Norrköping, Sweden

Karolinska Universitetssjukhuset; 🇸🇪 Stockholm, Sweden

Akademiska Sjukhuset; 🇸🇪 Uppsala, Sweden

Västmanlands Sjukhus Västerås; 🇸🇪 Västerås, Sweden

Kantonsspital Aarau; 🇨🇭 Aarau, Aargau, Switzerland

Kantonsspital Baden; 🇨🇭 Baden, Aargau, Switzerland

Kantonsspital St. Gallen; 🇨🇭 Saint Gallen, Sankt Gallen, Switzerland

Inselspital Universitätsspital Bern; 🇨🇭 Bern, Switzerland

Cardiocentro Ticino; 🇨🇭 Lugano, Switzerland

UniversitätsSpital Zürich; 🇨🇭 Zürich, Switzerland

Ataturk Universitesi Tip Fakultesi; 🇹🇷 Erzurum, Turkey

Izmir Ekonomi Universitesi Medikal Point Hastanesi; 🇹🇷 Izmir, Turkey

Russells Hall Hospital; 🇬🇧 Dudley, West Midlands, United Kingdom

Ely Bridge Medical Centre; 🇬🇧 Cardiff, United Kingdom

Life Spring Research | Miami, FL; 🇺🇸 Miami, Florida, United States

Veterans Benefits Administration | Minneapolis VA Medical Center - Cardiology Department; 🇺🇸 Minneapolis, Minnesota, United States

Duke University | Duke Clinical Research Institute - Participant Research Operations; 🇺🇸 Durham, North Carolina, United States

South Texas Cardiovascular Consultants, PLLC; 🇺🇸 San Antonio, Texas, United States

The 1st Affiliated Hospital Fujian Medical University; 🇨🇳 Fuzhou, Fujian, China

Guangzhou First People Hospital; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital of NanChang University; 🇨🇳 Nanchang, Jiangxi, China

Yan'an University Xianyang Hospital; 🇨🇳 Xianyang, Shaanxi, China

General Hospital of Ningxia Medical University; 🇨🇳 Yinchuan, Ningxia, China

The First Affiliated Hospital of Wenzhou Medical University; 🇨🇳 Wenzhou, Zhejiang, China

Peking University First Hospital; 🇨🇳 Beijing, China

A.O. di Perugia; 🇮🇹 Perugia, Umbria, Italy

Siteworks Pruefzentrum Voelklingen; 🇩🇪 Voelklingen, Saarland, Germany

Hospital Cardio Pulmonar | Salvador, Brazil; 🇧🇷 Salvador, Bahia, Brazil

Irmandade da Santa Casa de Misericordia de Porto Alegre | Hospital Sao Francisco - Centro Medico Pesquisa Clinica Cardiologia; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Queen Elizabeth the Queen Mother Hospital; 🇬🇧 Margate, Kent, United Kingdom

Universitätsspital Basel; 🇨🇭 Basel, Basel-Stadt, Switzerland

South Oklahoma Heart Research, LLC; 🇺🇸 Oklahoma City, Oklahoma, United States

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States

Capital Region | Amager Hospital - Cardiology Outpatient Clinic; 🇩🇰 Copenhagen, Denmark

Region Nordjylland | Aalborg University Hospital - Cardiology Department; 🇩🇰 Aalborg, Denmark

Sydvestjysk Sygehus Esbjerg | Kardiologisk Forskningsenhed; 🇩🇰 Esbjerg, Denmark

Capital Region | Frederiksberg Hospital - Department of Cardiology Research; 🇩🇰 Frederiksberg, Denmark

Capital Region | Gentofte Hospital - Cardiology Research; 🇩🇰 Hellerup, Denmark

Capital Region | Herlev Hospital - Department of Heart Disease; 🇩🇰 Herlev, Denmark

Region Nordjylland | Hjoerring - Cardiology Department; 🇩🇰 Hjørring, Denmark

Region Sjælland | Holbaek Sygehus - Cardiology department; 🇩🇰 Holbæk, Denmark

Sygehus Lillebaelt | Kolding Sygehus - Medicinske Sygdomme; 🇩🇰 Kolding, Denmark

Sjællands Universitetshospital Roskilde - Hormon og stofskiftesygdomme; 🇩🇰 Roskilde, Denmark

Region Midtjylland | Aarhus University Hospital - Heart Diseases - Clinical Research; 🇩🇰 Århus N, Denmark

Hopital Charles Nicolle Chu Rouen; 🇫🇷 Bois-Guillaume, France

CHU de Caen - Hôpital Côte de Nacre; 🇫🇷 CAEN cedex 9, France

Hôpital Pasteur - Nice; 🇫🇷 Nice, France

Hospital de Base | Integrated Research Center; 🇧🇷 São José do Rio Preto, Sao Paulo, Brazil

Baptist Health Lexington; 🇺🇸 Lexington, Kentucky, United States

University of South Alabama Medical Center; 🇺🇸 Mobile, Alabama, United States

Arkansas Cardiology | Little Rock; 🇺🇸 Little Rock, Arkansas, United States

Science 37; 🇺🇸 Culver City, California, United States

Valley Clinical Trials, Inc. | Covina, CA; 🇺🇸 Covina, California, United States

VA Greater Los Angeles Healthcare System | West Los Angeles VA Medical Center - Cardiology Department; 🇺🇸 Los Angeles, California, United States

Cottage Health | Santa Barbara Cottage Hospital - Cardiology Department; 🇺🇸 Santa Barbara, California, United States

NorthBay Clinical Research, LLC | Santa Rosa, CA; 🇺🇸 Santa Rosa, California, United States

Harbor - UCLA Medical Center; 🇺🇸 Torrance, California, United States

The Lundquist Institute | Cardiology Department; 🇺🇸 Torrance, California, United States

Blue Coast Research Center, LLC; 🇺🇸 Vista, California, United States

South Denver Cardiology Associates, PC; 🇺🇸 Littleton, Colorado, United States

Cardiology Associates of Fairfield County, P.C. | Stamford, CT; 🇺🇸 Norwalk, Connecticut, United States

Integrity Clinical Research | Florida Premier Cardiology; 🇺🇸 Boynton Beach, Florida, United States

Cardiovascular & Vein Center of Florida | Bradenton, FL; 🇺🇸 Bradenton, Florida, United States

Nova Clinical Research | Brandenton, FL; 🇺🇸 Bradenton, Florida, United States

Clearwater Cardiovascular Associates | Clearwater, FL; 🇺🇸 Clearwater, Florida, United States

Cardiology Associates Research Company; 🇺🇸 Daytona Beach, Florida, United States

Integrity Clinical Research | Heller Heart Health; 🇺🇸 Delray Beach, Florida, United States

Indago Research and Health Center | Hialeah, FL; 🇺🇸 Hialeah, Florida, United States

Encore Research Group | Nature Coast Clinical Research - Inverness; 🇺🇸 Inverness, Florida, United States

Advanced Research for Health Improvement, LLC | Naples, FL; 🇺🇸 Naples, Florida, United States

Heart Vein & Vascular | Longwood, FL; 🇺🇸 Longwood, Florida, United States

Cardiology Partners Clinical Research Institute | Palm Beach Gardens Office; 🇺🇸 Palm Beach Gardens, Florida, United States

Baptist Heart and Vascular/Cardiology Consultants; 🇺🇸 Pensacola, Florida, United States

Encore Research Group | St. Johns Center for Clinical Research; 🇺🇸 Saint Augustine, Florida, United States

East Coast Institute for Research | St. Augustine, FL; 🇺🇸 Saint Augustine, Florida, United States

Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota, FL; 🇺🇸 Sarasota, Florida, United States

Cardiology Partners Clinical Research Institute | Wellington Office; 🇺🇸 Wellington, Florida, United States

St. Mary's Medical Center | West Palm Beach - Neurology Department; 🇺🇸 West Palm Beach, Florida, United States

Morehouse School of Medicine | Clinical Research Centre; 🇺🇸 Atlanta, Georgia, United States

Alta Pharmaceutical Research Center, LLC; 🇺🇸 Peachtree Corners, Georgia, United States

St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology Associates; 🇺🇸 Meridian, Idaho, United States

Northshore Medical Center; 🇺🇸 Glenview, Illinois, United States

Atlanta Heart Specialists, LLC; 🇺🇸 Tucker, Georgia, United States

Affinity Health Research Institute | Oak Brook, IL; 🇺🇸 Oak Brook, Illinois, United States

IU Health Physicians Cardiology; 🇺🇸 Indianapolis, Indiana, United States

Cardiovascular Research of Northwest Indiana, LLC. | Munster, IN; 🇺🇸 Hammond, Indiana, United States

Reid Physician Associates | Cardiology Department; 🇺🇸 Richmond, Indiana, United States

Accellacare | Ames, IA; 🇺🇸 Ames, Iowa, United States

University of Iowa; 🇺🇸 Iowa City, Iowa, United States

Kansas Nephrology Physicians, PA; 🇺🇸 Wichita, Kansas, United States

Research Integrity, LLC; 🇺🇸 Owensboro, Kentucky, United States

Cambridge Medical Trials; 🇺🇸 Alexandria, Louisiana, United States

Spectrum Clinical Research | Maryland Cardiovascular Specialists; 🇺🇸 Baltimore, Maryland, United States

McLaren Health Care | McLaren Bay Region - Research Department; 🇺🇸 Bay City, Michigan, United States

LifeBridge Health | Sinai Hospital - Platelet and Thrombosis Research Department; 🇺🇸 Baltimore, Maryland, United States

Johns Hopkins Hospital/Health System; 🇺🇸 Baltimore, Maryland, United States

Johns Hopkins University School of Medicine | CAPRES; 🇺🇸 Columbia, Maryland, United States

Adventist HealthCare | White Oak Medical Center; 🇺🇸 Silver Spring, Maryland, United States

Henry Ford Health System; 🇺🇸 Detroit, Michigan, United States

Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research Department; 🇺🇸 Lansing, Michigan, United States

AA Medical Research Center | Flint, MI; 🇺🇸 Flint, Michigan, United States

St. Louis Heart & Vascular, PC; 🇺🇸 Saint Louis, Missouri, United States

IMA Clinical Research | Warren, NJ; 🇺🇸 Warren, New Jersey, United States

Division of Cardiovascular Research at Peconic Bay Med Ctr; 🇺🇸 Riverhead, New York, United States

Medication Management | Greensboro - Cardiology; 🇺🇸 Greensboro, North Carolina, United States

Duke Univ. Medical Center; 🇺🇸 Durham, North Carolina, United States

Lillestol Research LLC | Fargo, ND; 🇺🇸 Fargo, North Dakota, United States

Kettering Health Network | Research Institute; 🇺🇸 Kettering, Ohio, United States

Aultman | Aultman Hospital Main Campus - Clinical Trials; 🇺🇸 Canton, Ohio, United States

Rama Research LLC | Marion, OH; 🇺🇸 Marion, Ohio, United States

ProMedica Toledo Hospital; 🇺🇸 Toledo, Ohio, United States

Capital Area Research | Camp Hill, PA; 🇺🇸 Camp Hill, Pennsylvania, United States

Doylestown Hospital; 🇺🇸 Doylestown, Pennsylvania, United States

University of Pittsburgh Medical Center, Hamot | Clinical Trials and Research; 🇺🇸 Erie, Pennsylvania, United States

Geisinger Community Medical Center; 🇺🇸 Scranton, Pennsylvania, United States

Einstein Healthcare Network; 🇺🇸 Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital; 🇺🇸 Philadelphia, Pennsylvania, United States

University of Pittsburgh Medical Center Health System; 🇺🇸 Pittsburgh, Pennsylvania, United States

Main Line Health; 🇺🇸 Wynnewood, Pennsylvania, United States

Geisinger Wyoming Valley Medical Center; 🇺🇸 Wilkes-Barre, Pennsylvania, United States

Lifespan | The Miriam Hospital - Cardiovascular Research; 🇺🇸 Providence, Rhode Island, United States

AnMed Clinical Research; 🇺🇸 Anderson, South Carolina, United States

Piedmont Research Partners LLC; 🇺🇸 Fort Mill, South Carolina, United States

Sanford USD Medical Center; 🇺🇸 Sioux Falls, South Dakota, United States

Stern Cardiovascular Center; 🇺🇸 Germantown, Tennessee, United States

Apex Research Foundation, LLC. | Jackson, TN; 🇺🇸 Jackson, Tennessee, United States

PharmaTex Research, LLC; 🇺🇸 Amarillo, Texas, United States

Southwest Family Medicine Associates | Dallas, TX; 🇺🇸 Dallas, Texas, United States

Prime Revival Reserach Institute, LLC | Denton, TX; 🇺🇸 Denton, Texas, United States

David Turbay MD PLLC; 🇺🇸 El Paso, Texas, United States

Houston Methodist Hospital; 🇺🇸 Houston, Texas, United States

Texas Health Research & Education Institute; 🇺🇸 Fort Worth, Texas, United States

Texas Health Physicians Group - Fort Worth; 🇺🇸 Fort Worth, Texas, United States

University of Texas Medical Branch at Galveston; 🇺🇸 Galveston, Texas, United States

North Dallas Research Associate | McKinney, TX; 🇺🇸 McKinney, Texas, United States

North Texas Research Associates; 🇺🇸 McKinney, Texas, United States

Styde Research LLC | Plano, TX; 🇺🇸 Plano, Texas, United States

Clinical Advancement Center, PLLC; 🇺🇸 San Antonio, Texas, United States

Northwest Houston Clinical Research, PLLC - Houston Heart Center | Tomball, TX; 🇺🇸 Tomball, Texas, United States

Mt. Olympus Medical Research; 🇺🇸 Sugar Land, Texas, United States

Tyler Cardiovascular Consultants | Tyler, TX; 🇺🇸 Tyler, Texas, United States

Intermountain Healthcare | Cardiovascular Research Department; 🇺🇸 Murray, Utah, United States

Confluence Health; 🇺🇸 Wenatchee, Washington, United States

Inova Fairfax Hospital - Fairfax; 🇺🇸 Fairfax, Virginia, United States

Virginia Heart; 🇺🇸 Falls Church, Virginia, United States

Hospital Italiano de La Plata | Clinical Research Department; 🇦🇷 La Plata, Buenos Aires, Argentina

Carient Heart and Vascular; 🇺🇸 Manassas, Virginia, United States

Instituto de Investigaciones Clínicas (IIC) San Nicolas | San Nicolas de los Arroyos, Argentina; 🇦🇷 San Nicolás, Buenos Aires, Argentina

CardioAlem Investigaciones | San Isidro, Argentina; 🇦🇷 San Isidro, Buenos Aires, Argentina

CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina; 🇦🇷 Caba, Ciudad Auton. De Buenos Aires, Argentina

Centro de Investigaciones Clinicas del Litoral | Santa Fe, Argentina; 🇦🇷 Santa Fe, Argentina

Sunshine Coast University Hospital; 🇦🇺 Birtinya, Queensland, Australia

Gold Coast University Hospital; 🇦🇺 Southport, Queensland, Australia

Core Research Group Pty Ltd. | Brisbane, Australia; 🇦🇺 Taringa QLD, Queensland, Australia

Flinders Medical Centre; 🇦🇺 Bedford Park, South Australia, Australia

Advara HealthCare Leabrook; 🇦🇺 Leabrook, South Australia, Australia

Eastern Health; 🇦🇺 Box Hill, Victoria, Australia

The Alfred Hospital; 🇦🇺 Melbourne, Victoria, Australia

Advara HeartCare Melbourne; 🇦🇺 Ringwood, Victoria, Australia

Mayo Clinic - Rochester; 🇺🇸 Rochester, Minnesota, United States

Fiona Stanley Hospital; 🇦🇺 Murdoch, Western Australia, Australia

Advara HealthCare Joondalup; 🇦🇺 Perth, Western Australia, Australia

Landesklinikum Mistelbach|Kardiologie u. Internistische Med; 🇦🇹 Mistelbach, Niederösterreich, Austria

Krankenhaus St. Josef Braunau | Innere Medizin I; 🇦🇹 Braunau, Oberösterreich, Austria

Klinikum Wels-Grieskirchen | Innere Medizin II; 🇦🇹 Wels, Oberösterreich, Austria

Kepler UK Linz | Kardiologie & Intensivmedizin Campus III; 🇦🇹 Linz, Oberösterreich, Austria

MedUni Graz | Kardiologie; 🇦🇹 Graz, Steiermark, Austria

MedUni Innsbruck | Kardiologie und Angiologie; 🇦🇹 Innsbruck, Tirol, Austria

Uniklinikum Salzburg|Innere Medizin II, Kardiologie; 🇦🇹 Salzburg, Austria

Imed19-privat; 🇦🇹 Wien, Austria

GZA Ziekenhuizen | Saint Augustine Campus - Cardiology Department; 🇧🇪 Wilrijk, Antwerpen, Belgium

University Hospital Louvain Namur | Godinne - Cardiology Department; 🇧🇪 Yvoir, Namur, Belgium

CU Saint-Luc/UZ St-Luc; 🇧🇪 Bruxelles - Brussel, Belgium

AZ Sint-Maarten; 🇧🇪 Duffel, Belgium

Ziekenhuis Oost-Limburg | Genk, Sint-Jan campus - Cardiology Department; 🇧🇪 Genk, Belgium

Grand Hôpital de Charleroi; 🇧🇪 Gilly, Belgium

Jessa Ziekenhuis; 🇧🇪 Hasselt, Belgium

Citadelle Hospital | Cardiology Department; 🇧🇪 Liege, Belgium

Vitaz | Sint-Niklaas Hospital - Cardiology Department; 🇧🇪 Sint-Niklaas, Belgium

CHC MontLégia Neurology Department; 🇧🇪 Liège, Belgium

AZ Delta | Clinical Trial Center - Cardiology; 🇧🇪 Roeselare, Belgium

Cardresearch Cardiologia Assistencial e de Pesquisa | Belo Horizonte, Brazil; 🇧🇷 Belo Horizonte, Minas Gerais, Brazil

Hospital das Clinicas da Universidade Federal de Goias | Centro de Pesquisa em Cardiologia; 🇧🇷 Goiânia, Goiás, Brazil

Hospital Maternidade e Pronto Socorro Santa Lucia | Hospital do Coracao - Research Center; 🇧🇷 Poços de Caldas, Minas Gerais, Brazil

Nucleo de Pesquisa Clinica | Curitiba, Brazil; 🇧🇷 Curitiba, Parana, Brazil

Hospital de Clinicas de Porto Alegre | Clinical Research Center - Surgery Research Center; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

FZ Pesquisa e Servicos em Cardiologia | Porto Alegre, Brazil; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

CardioBlu | Unidade Sabin; 🇧🇷 Blumenau, Santa Catarina, Brazil

UNESP Faculdade de Medicina de Botucatu | UPECLIN; 🇧🇷 Botucatu, Sao Paulo, Brazil

Campinas Clinical Research Institute (IPECC) | Campinas, Brazil; 🇧🇷 Campinas, Sao Paulo, Brazil

Hospital e Maternidade Sao Luiz; 🇧🇷 São Paulo, Sao Paulo, Brazil

Hospital PUC-Campinas | Centro de Pesquisa Clínica Sao Lucas; 🇧🇷 São Paulo, Sao Paulo, Brazil

Eurolatino Pesquisas Medicas | Uberlandia, MG; 🇧🇷 Minas Gerais, Brazil

Hospital Sao Lucas Copacabana | Clinical Research Department; 🇧🇷 Rio de Janeiro, Brazil

Hospital Alemao Oswaldo Cruz | Centro Internacional de Pesquisa; 🇧🇷 Sao Paulo, Brazil

Multidisciplinary Hospital for Active Treatment Heart and Brain Burgas | Cardiology Department; 🇧🇬 Burgas, Bulgaria

Medical centre Hipokrat - N EOOD; 🇧🇬 Plovdiv, Bulgaria

Medical Center Avitsena Kardzhali | Cardiology Clinic; 🇧🇬 Kardzhali, Bulgaria

Multiprofile Hospital for Active Treatment Medline | Cardiology Department; 🇧🇬 Plovdiv, Bulgaria

Multiprofile Hospital for Active Treatment Sveta Karidad | Cardiology Department; 🇧🇬 Plovdiv, Bulgaria

Multiprofile Hospital for Active Treatment | Shumen - First Department of Internal Medicine; 🇧🇬 Shumen, Bulgaria

Diagnostic Consultative Center Ascendent | Sofia, Bulgaria; 🇧🇬 Sofia, Bulgaria

Cardiohelp Medical Centre | Sofia, Bulgaria; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital for Active Treatment National Cardiology Hospital | Cardiology Department; 🇧🇬 Sofia, Bulgaria

Diagnostic-Consultative Center XX | Cardiology Department; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital for Active Treatment Sveta Sofia | Internal Diseases Department; 🇧🇬 Sofia, Bulgaria

Multiprofile Hospital for Active Treatment Trakiya Park | Cardiology Department; 🇧🇬 Stara Zagora, Bulgaria

Multiprofile Hospital for Active Treatment Dr. Stefan Cherkezov | Cardiology Department; 🇧🇬 Veliko Tarnovo, Bulgaria

Interior Health - Royal Inland Hospital; 🇨🇦 Kamloops,, British Columbia, Canada

Fraser Clinical Trials, Inc.; 🇨🇦 New Westminster, British Columbia, Canada

Victoria Heart Institute Foundation; 🇨🇦 Victoria, British Columbia, Canada

G.A. Research Associates, Ltd.; 🇨🇦 Moncton, New Brunswick, Canada

Cambridge Cardiac Care Center; 🇨🇦 Cambridge, Ontario, Canada

McMaster University Medical Centre; 🇨🇦 Hamilton, Ontario, Canada

Hamilton Health Sciences; 🇨🇦 Hamilton, Ontario, Canada

Milestone Research; 🇨🇦 London, Ontario, Canada

Oakville Cardiovascular Research; 🇨🇦 Oakville, Ontario, Canada

Dr. James Cha; 🇨🇦 Oshawa, Ontario, Canada

Kawartha Cardiology Clinical Trials; 🇨🇦 Peterborough, Ontario, Canada

Heart Health Institute; 🇨🇦 Scarborough, Ontario, Canada

St. Michael's Hospital; 🇨🇦 Toronto, Ontario, Canada

Sunnybrook Health Sciences Centre; 🇨🇦 Toronto, Ontario, Canada

Toronto General Hospital UHN; 🇨🇦 Toronto, Ontario, Canada

Dr. Louis Yao; 🇨🇦 York, Ontario, Canada

Women's College Hospital | WCH Main Site - Women's College Research Institute - Cardiology Department; 🇨🇦 Toronto, Ontario, Canada

Viacar Recherches Cliniques Inc.; 🇨🇦 Brossard, Quebec, Canada

McGill University Health Centre - Glen Site; 🇨🇦 Montreal, Quebec, Canada

CIUSSS NÎM Hôpital Sacré-Coeur; 🇨🇦 Montreal, Quebec, Canada

Montreal Heart Institute; 🇨🇦 Montréal,, Quebec, Canada

CIUSSS de l'Estrie-CHUS, Hopital Fleurimont; 🇨🇦 Sherbrooke, Quebec, Canada

CISSSL - Hopital Pierre-Le Gardeur; 🇨🇦 Terrebonne, Quebec, Canada

Diex Research Trois-Rivières Inc.; 🇨🇦 Trois-Rivieres, Quebec, Canada

Institut universitaire de cardiologie et de pneumologie de Q; 🇨🇦 Québec, Canada

Xiamen Cardiovascular Hospital Xiamen University; 🇨🇳 Xiamen, Fujian, China

CHU de Québec-Université Laval; 🇨🇦 Quebec, Canada

Lanzhou University Second Hospital; 🇨🇳 Lanzhou, Gansu, China

Guangdong Provincial People's Hospital; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital of Guangzhou University of TCM; 🇨🇳 Guangzhou, Guangdong, China

The First Affiliated Hospital of Jinan University; 🇨🇳 Guangzhou, Guangdong, China

Guangzhou Panyu Central Hospital; 🇨🇳 Guangzhou, Guangdong, China

The 2nd Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, Guangdong, China

Huizhou Central People's Hospital; 🇨🇳 Huizhou, Guangdong, China

Hainan Third People's Hospital (Province Nongken Sanya Hopt); 🇨🇳 Sanya, Hainan, China

Cangzhou Central Hospital; 🇨🇳 Cangzhou, Hebei, China

The First Hospital of Hebei Medical Univesity; 🇨🇳 Shijiazhuang, Hebei, China

The First affiliated Hospital of Hebei North University; 🇨🇳 Zhangjiakou, Hebei, China

The 4th Affiliated Hospital of Harbin Medical University; 🇨🇳 Harbin, Heilongjiang, China

Daqing Oilfield General Hospital; 🇨🇳 Daqing, Heilongjiang, China

The First Affiliated Hospital of Harbin Medical University; 🇨🇳 Harbin, Heilongjiang, China

Luoyang Third People's Hospital; 🇨🇳 Luoyang, Henan, China

1st Affiliated Hospital of Henan Science and Technology Univ; 🇨🇳 Luoyang, Henan, China

Xinxiang Central Hospital; 🇨🇳 Xinxiang, Henan, China

The Central Hospital of Wuhan, Tongji Medl Collg Huazhong...; 🇨🇳 Wuhan, Hubei, China

Union Hospt Tongji Medical Colleg. Huazhong univ. Scien&Tech; 🇨🇳 Wuhan, Hubei, China

Renmin Hosp., Wuhan Univ.; 🇨🇳 Wuhan, Hubei, China

The First Affiliated Hospital of Baotou Medical College; 🇨🇳 Baotou, Inner Mongolia, China

The Third Xiangya Hospital of Central South University; 🇨🇳 Changsha, Hunan, China

The Third Hospital of Changsha; 🇨🇳 Changsha, Hunan, China

Baotou Central Hospital; 🇨🇳 Baotou, Inner Mongolia, China

Affiliated Hospital of Jiangsu University; 🇨🇳 JiangSu, Jiangsu, China

The Second Affiliated Hospital of Nanjing Medical university; 🇨🇳 Nanjing, Jiangsu, China

Zhongda Hospital Southeast University; 🇨🇳 Nanjing, Jiangsu, China

Taizhou People's Hospital; 🇨🇳 Taizhou, Jiangsu, China

Nanjing Jiangning Hospital; 🇨🇳 Nanjing, Jiangsu, China

Northern Jiangsu People's Hospital; 🇨🇳 Yangzhou, Jiangsu, China

Jiangxi Provincial People's Hospital; 🇨🇳 Nanchang, Jiangxi, China

Jiangxi PingXiang people's Hospital; 🇨🇳 Pingxiang, Jiangxi, China

The Third Hospital of Nanchang; 🇨🇳 Nanchang, Jiangxi, China

China-Japan Union Hospital of Jilin University; 🇨🇳 Changchun, Jilin, China

The First Affiliated Hospital of Jinzhou Medical University; 🇨🇳 Jinzhou, Liaoning, China

Yinchuan No.1 People's Hospital; 🇨🇳 Yinchuan, Ningxia, China

Panjin Liaohe Oilfield Gem Flower Hospital; 🇨🇳 Panjin, Liaoning, China

Qinghai University Affiliated Hospital; 🇨🇳 Xining, Qinghai, China

Jinan Central Hospital; 🇨🇳 Jinan, Shandong, China

Affiliated Hospital of Jining Medical University; 🇨🇳 Jining, Shandong, China

Qilu Hosp., Shandong Univ.; 🇨🇳 Jinan, Shandong, China

Jining No.1 People's Hospital; 🇨🇳 Jining, Shandong, China

Taian City Central Hospital; 🇨🇳 Taian, Shandong, China

Shanxi Candiovascular Hospital; 🇨🇳 Taiyuan, Shanxi, China

Shaanxi Provincial People's Hospital; 🇨🇳 Xi'an, Shanxi, China

Zibo Central Hospital; 🇨🇳 Zibo, Shandong, China

Shanxi Bethune Hospital; 🇨🇳 Taiyuan, Shanxi, China

Chengdu Second People's Hospital; 🇨🇳 Chengdu, Sichuan, China

West China Hospital,Sichuan University; 🇨🇳 Chengdu, Sichuan, China

SichuanAcademyofMedicalSciences&SichuanProvincialPeople'sHos; 🇨🇳 Chengdu, Sichuan, China

People's Hospital of Deyang City; 🇨🇳 Deyang, Sichuan, China

The First Affiliated Hospital of Xinjiang Medical University; 🇨🇳 Urumchi, Xinjiang, China

Ningbo First Hospital; 🇨🇳 Ningbo, Zhejiang, China

The 1st Affiliated Hospital of Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China

Taizhou Hospital of Zhejiang Province; 🇨🇳 Taizhou, Zhejiang, China

Klinikum Worms gGmbH|Kardiologie und Angiologie; 🇩🇪 Worms, Rheinland-Pfalz, Germany

Klinische Forschung Dresden | Dresden, Germany; 🇩🇪 Dresden, Sachsen, Germany

Beijing Anzhen Hospital, Capital Medical University; 🇨🇳 Beijing, China

Beijing Chaoyang Hospital, Capital Medical University; 🇨🇳 Beijing, China

China-Japan Friendship Hospital; 🇨🇳 Beijing, China

Peking Union Medical College Hospital CAMS; 🇨🇳 Beijing, China

Beijing Tsinghua Changgung Hospital; 🇨🇳 Beijing, China

Zhongshan Hospital, Fudan University; 🇨🇳 Shanghai, China

Huashan Hospital, Fudan University; 🇨🇳 Shanghai, China

Shanghai Putuo District Central Hospital; 🇨🇳 Shanghai, China

Shanghai General Hospital; 🇨🇳 Shanghai, China

Tianjin People's Hospital; 🇨🇳 Tianjin, China

Teda International Cardiovascular Hospital; 🇨🇳 Tianjin, China

Cardio Research s.r.o.; 🇨🇿 Zlin, Zlínský Kraj, Czechia

Kardiologicka ambulance Brno s.r.o.; 🇨🇿 Brno, Czechia

Fakultni nemocnice Brno; 🇨🇿 Brno, Czechia

Amkardia s.r.o.; 🇨🇿 Brno, Czechia

Fakultni Nemocnice Olomouc; 🇨🇿 Olomouc, Czechia

MATMED s.r.o.; 🇨🇿 Hodonin, Czechia

Krajska Nemocnice Liberec; 🇨🇿 Liberec, Czechia

Fakultni nemocnice Plzen; 🇨🇿 Plzen, Czechia

MUDr. Michalik s.r.o.; 🇨🇿 Ostrava-Zabreh, Czechia

Fakultni nemocnice Kralovske Vinohrady; 🇨🇿 Praha 10, Czechia

Institut Klinicke a Experimentalni Mediciny; 🇨🇿 Praha 4, Czechia

Nemocnice Slany; 🇨🇿 Slany, Czechia

Region Midtjylland | Regionshospitalet Godstrup - Clinic for Heart Research; 🇩🇰 Herning, Denmark

Capital Region | Nordsjaellands Hospital - Hillerod - Cardiology Department; 🇩🇰 Hilleroed, Denmark

Capital Region | Hvidovre Hospital - Department of Cardiology; 🇩🇰 Hvidovre, Denmark

Odense University Hospital | Svendborg Hospital - Cardiovascular Research Unit; 🇩🇰 Svendborg, Denmark

Region Midtjylland | Viborg Regional Hospital - Cardiology - Heart Research; 🇩🇰 Viborg, Denmark

Rapla Family Doctors Centre; 🇪🇪 Rapla, Estonia

East Tallinn Central Hospital; 🇪🇪 Tallinn, Estonia

North Estonia Medical Centre Foundation; 🇪🇪 Tallinn, Estonia

Pirita Family Doctors Centre; 🇪🇪 Tallinn, Estonia

Tartu University Hospital; 🇪🇪 Tartu, Estonia

West Tallinn Central hospital; 🇪🇪 Tallinn, Estonia

Kuopion yliopistollinen sairaala; 🇫🇮 Kuopio, Finland

Tays Sydänsairaala; 🇫🇮 Tampere, Finland

Hôpital La Cavale Blanche - CHU de Brest; 🇫🇷 Brest, France

Centre Hospitalier - Cholet; 🇫🇷 Cholet, France

CHU GRENOBLE - Hopital Michallon; 🇫🇷 GRENOBLE Cedex 09, France

Centre Hospitalier Départemental Vendée; 🇫🇷 LA ROCHE SUR YON cedex, France

Nouvelles Cliniques Nantaises - Nantes; 🇫🇷 NANTES cedex 2, France

Hôpital de la Pitié-Salpétrière; 🇫🇷 Paris, France

Hôpital de Rangueil - Toulouse; 🇫🇷 TOULOUSE cedex, France

CHI Toulon - H La Seyne - Cardiologie; 🇫🇷 Toulon, France

Clinique Pasteur - Toulouse; 🇫🇷 Toulouse, France

Centre Hospitalier Gustave Dron - Tourcoing; 🇫🇷 Tourcoing, France

Centre Hospitalier - Valenciennes Cedex; 🇫🇷 Valenciennes, France

Centre Hospitalier Universitaire de Nancy; 🇫🇷 Vandoeuvre-les-nancy, France

Cardio Centrum Ludwigsburg; 🇩🇪 Ludwigsburg, Baden-Württemberg, Germany

Hegau-Bodensee-Klinikum Singen|I. Medizinische Klinik; 🇩🇪 Singen, Baden-Württemberg, Germany

Medizinische Hochschule Hannover|Kardiologie und Angiologie; 🇩🇪 Hannover, Niedersachsen, Germany

St.Johannes-Hospital|Klinik fuer Innere Medizin I; 🇩🇪 Dortmund, Nordrhein-Westfalen, Germany

Kliniken Maria Hilf GmbH; 🇩🇪 Mönchengladbach, Nordrhein-Westfalen, Germany

Josephs-Hospital|Kardiologie, Rhythmologie und Angiologie; 🇩🇪 Warendorf, Nordrhein-Westfalen, Germany

KAT General Hospital of Athens; 🇬🇷 Kifisia, Attica, Greece

General Hospital of Athens "Evangelismos"; 🇬🇷 Athens, Greece

Naval Hospital of Athens; 🇬🇷 Athens, Greece

LAIKO General Hospital of Athens; 🇬🇷 Athens, Greece

Univ. General Hospital of Larissa; 🇬🇷 Larissa, Greece

Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA; 🇬🇷 Nea Ionia, Greece

MITERA Hospital; 🇬🇷 Marousi, Greece

Hippokration General Hospital of Thessaloniki; 🇬🇷 Thessaloniki, Greece

Cardiomobile Egeszsegugyi Szolgaltato Kft.; 🇭🇺 Balatonfured, Hungary

Semmelweis University; 🇭🇺 Budapest, Hungary

Kardio Egeszseghaz - Dr Amer Sayour Egyeni Vallakozo; 🇭🇺 Gyor, Hungary

Trial Pharma Kft. Gyula; 🇭🇺 Gyula, Hungary

Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet; 🇭🇺 Budapest, Hungary

Komaromi Selye Janos Korhaz; 🇭🇺 Komarom, Hungary

TaNa Med Kft.; 🇭🇺 Mosonmagyarovar, Hungary

Dr. Nagy Laszlo Egyeni Egeszsegugyi Vallalkozo; 🇭🇺 Oroshaza, Hungary

Complex Rendelo Med Zrt.; 🇭🇺 Szekesfehervar, Hungary

Coromed Smo Kft; 🇭🇺 Pecs, Hungary

Belvarosi Egeszseghaz Kft.; 🇭🇺 Zalaegerszeg, Hungary

Clalit Health | Soroka Medical Center - Internal Medicine Department; 🇮🇱 Beer Sheva, Israel

Rambam Health Care Campus | Cardiology Department - Cardiology Research Unit; 🇮🇱 Haifa, Israel

Bnai Zion Medical Center | Cardiology Department; 🇮🇱 Haifa, Israel

Carmel Medical Center | Cardiology Department - Cardiac Catheterization Unit; 🇮🇱 Haifa, Israel

Edith Wolfson Medical Center | Internal Medicine Department; 🇮🇱 Holon, Israel

Clalit Health | Meir Medical Center - Division of Cardiology - Electrophysiology and Arrhythmias Unit; 🇮🇱 Jerusalem, Israel

Shaare Zedek Medical Center | The Jesselson Integrated Heart Center - Cardiology Department; 🇮🇱 Jerusalem, Israel

Poria Medical Center | Cardiovascular Department; 🇮🇱 Lower Galilee, Israel

Rabin Medical Center | Clinical Trials Unit - Cardiology Department; 🇮🇱 Petah Tikva, Israel

Asl Roma 2; 🇮🇹 Roma, Lazio, Italy

A.O.U. Policlinico Umberto I; 🇮🇹 Roma, Lazio, Italy

Humanitas Mirasole S.p.A. - Centro Trombosi e Malattie Emorragiche; 🇮🇹 Rozzano, Lombardia, Italy

Ente Ecclesiastico Ospedale Generale Regionale Miulli; 🇮🇹 Bari, Puglia, Italy

Japan Culture and Welfare Federation of Agricultural Cooperatives | Toyota Kosei Hospital; 🇯🇵 Toyota-City, Aichi-ken, Japan

Nippon Medical School Chiba Hokusoh Hospital | Clinical Trial Office; 🇯🇵 Inzai, Chiba, Japan

Munakata Suikokai General Hospital | Cardiology Department; 🇯🇵 Fukutsu, Fukuoka, Japan

Japan Culture and Welfare Federation of Agricultural Cooperatives | ShirakawaKosei General Hospital; 🇯🇵 Shirakawa-city, Fukushima-ken, Japan

Mazda Motor Corporation Mazda Hospital; 🇯🇵 Aki-gun, Hiroshima, Japan

National Hospital Organization Takasaki General Medical Center; 🇯🇵 Takasaki, Gunma, Japan

Hakodate Municipal Hospital; 🇯🇵 Hakodate, Hokkaido, Japan

Miyanomori Memorial Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

Tomakomai City Hospital; 🇯🇵 Tomakomai, Hokkaido, Japan

Hyogo Prefectural HarimaHimeji General Medical Center; 🇯🇵 Himeji, Hyogo, Japan

Kobe City Medical Center General Hospital; 🇯🇵 Kobe, Hyogo, Japan

Higashi Takarazuka Satoh Hospital; 🇯🇵 Takarazuka, Hyogo, Japan

National hospital Organization Mito Medical Center; 🇯🇵 Higashiibaraki, Ibaraki, Japan

Mito Saiseikai General Hospital; 🇯🇵 Mito, Ibaraki, Japan

Public Central Hospital of Matto Ishikawa | Clinical Trial Management Office; 🇯🇵 Hakusan city, Ishikawa Ken, Japan

Iwate Prefectural Central Hospital; 🇯🇵 Morioka, Iwate, Japan

Mitoyo General Hospital | Kagawa, Japan; 🇯🇵 Toyohama-Cho,Kanonji-City, Kagawa, Japan

Hayama Heart Center | Clinical Trial Center; 🇯🇵 Miura-gun, Kanagawa, Japan

Japan Culture and Welfare Federation of Agricultural Cooperatives | Hokushin General Hospital; 🇯🇵 Nakano-City, Nagano-ken, Japan

Iida Hospital; 🇯🇵 Iida-city, Nagano, Japan

Asama Nanroku Komoro Medical Center | Komoro, Japan; 🇯🇵 Komoro, Nagano, Japan

Urasoe General Hospital | Clinical Research Support Center; 🇯🇵 Urasoe, Okinawa, Japan

Japanese Red Cross Society Suwa Hospital; 🇯🇵 Suwa, Nagano, Japan

R.I.A.C Naha City Hospital; 🇯🇵 Naha, Okinawa, Japan

Kishiwada Tokushukai Hospital; 🇯🇵 Kishiwada, Osaka, Japan

Osaka Saiseikai Senri Hospital; 🇯🇵 Suita, Osaka, Japan

Sakurabashi Watanabe Future Medical Hospital | Department of Cardiology; 🇯🇵 Umeda Kita-Ku, Osaka-shi, Osaka, Japan

Yao Tokushukai General Hospital | Clinical Research Center; 🇯🇵 Yao-city, Osaka, Japan

Ageo Central General Hospital; 🇯🇵 Ageo, Saitama, Japan

Kawaguchi Cardiovascular and Respiratory Hospital; 🇯🇵 Kawaguchi, Saitama, Japan

National Hospital Organization Hamada Medical Center; 🇯🇵 Hamada, Shimane, Japan

Dokkyo Medical University Hospital; 🇯🇵 Shimotsuga-gun, Tochigi, Japan

CliniPro Co.,Ltd. | Tokyo-Eki Center-building Clinic - Tokyo, Japan; 🇯🇵 Chuo-ku, Tokyo, Japan

Tokyo Angel Hospital | Clinical Trial Department; 🇯🇵 Hachioji, Tokyo, Japan

Minamino Cardiovascular Hospital; 🇯🇵 Hachioji, Tokyo, Japan

Machida Municipal Hospital; 🇯🇵 Machida, Tokyo, Japan

Tokyo Saiseikai Central Hospital | Clinical Research Center; 🇯🇵 Minato-ku, Tokyo, Japan

NewHeart Watanabe Institute; 🇯🇵 Suginami-ku, Tokyo, Japan

Tokyo Yamate Medical Center; 🇯🇵 Shinjuku-ku, Tokyo, Japan

National Hospital Organization Disaster Medical Center; 🇯🇵 Tachikawa, Tokyo, Japan

Yamanashi Prefectural Central Hospital; 🇯🇵 Kofu, Yamanashi, Japan

Fukui General Clinic; 🇯🇵 Fukui, Japan

Fukui Prefectural Hospital; 🇯🇵 Fukui, Japan

Social Medical Corporation the Chiyukai foundation Fukuoka Wajiro Hospital; 🇯🇵 Fukuoka, Japan

Fukuoka University Hospital; 🇯🇵 Fukuoka, Japan

Gifu Heart Center; 🇯🇵 Gifu, Japan

Tenyoukai Central Clinic; 🇯🇵 Kagoshima, Japan

Kyushu Central Hospital; 🇯🇵 Fukuoka, Japan

Kagoshima Medical Center; 🇯🇵 Kagoshima, Japan

Chikamori Hospital; 🇯🇵 Kochi, Japan

Kumamoto Kinoh Hospital; 🇯🇵 Kumamoto, Japan

Rakuwakai Otowa Hospital; 🇯🇵 Kyoto, Japan

The Sakakibara Heart Institute of Okayama; 🇯🇵 Okayama, Japan

CMIC HealthCare Institute Co. Ltd. | Local IAA OCGMC - Okayama City Civic Hospital - Clinical Trial Centre; 🇯🇵 Okayama, Japan

CMIC HealthCare Institute Co. Ltd. | Okayama Rosai Hospital - Clinical Trial Centre; 🇯🇵 Okayama, Japan

Osaka Saiseikai Nakatsu Hospital; 🇯🇵 Osaka, Japan

Osaka Police Hospital | Clinical Research and Trial Center; 🇯🇵 Osaka, Japan

Japan Community Health Care Organization Osaka Hospital; 🇯🇵 Osaka, Japan

Shizuoka City Shizuoka Hospital; 🇯🇵 Shizuoka, Japan

Sanai hospital; 🇯🇵 Saitama, Japan

Sainokuni Higashiomiya Medical Center; 🇯🇵 Saitama, Japan

Iwatsuki-minami Hospital; 🇯🇵 Saitama, Japan

Saiseikai Wakayama Hospital | Pharmaceutical department; 🇯🇵 Wakayama, Japan

Pusan National University Hospital; 🇰🇷 Busan, Busan Gwang''yeogsi, Korea, Republic of

Yonsei University Wonju Christian Hospital; 🇰🇷 Wonju, Gang''weondo, Korea, Republic of

Hallym University Sacred Heart Hospital; 🇰🇷 Anyang-si, Gyeonggido, Korea, Republic of

Nightingale Research; 🇦🇺 Adelaide, South Australia, Australia

Nepean Hospital; 🇦🇺 Kingswood, Australia

Ajou University Hospital; 🇰🇷 Suwon, Gyeonggido, Korea, Republic of

Bundang Cha Hospital; 🇰🇷 Seongnam-si, Gyeonggido, Korea, Republic of

Uijeongbu ST. Mary's Hospital; 🇰🇷 Uijeongbu-si, Gyeonggi-do, Gyeonggido, Korea, Republic of

Dong-A University Hospital; 🇰🇷 Busan, Korea, Republic of

Seoul National University Hospital; 🇰🇷 Seoul, Seoul Teugbyeolsi, Korea, Republic of

Keimyung University Dongsan Medical Center; 🇰🇷 Daegu, Korea, Republic of

Circuit Clinical/Crystal Run; 🇺🇸 Middletown, New York, United States

Gachon University Gil Medical Center; 🇰🇷 Incheon, Korea, Republic of

Severance Hospital, Yonsei University Health System; 🇰🇷 Seoul, Korea, Republic of

Great Lakes Medical Research | Westfield, NY; 🇺🇸 Westfield, New York, United States

NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular Research; 🇺🇸 New York, New York, United States

Korea University Anam Hospital; 🇰🇷 Seoul, Korea, Republic of

Chung-Ang University Hospital; 🇰🇷 Seoul, Korea, Republic of

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of

Doctor's Practice in Cardiology; 🇱🇻 Daugavpils, Latvia

SIA ARI Med; 🇱🇻 Daugavpils, Latvia

Daugavpils Regional Hospital; 🇱🇻 Daugavpils, Latvia

Rutas Eglites GP Practice; 🇱🇻 Kuldiga, Latvia

Liepaja Regional Hospital; 🇱🇻 Liepaja, Latvia

Lija Mora physician practice; 🇱🇻 Ogre, Latvia

P. Stradins Clinical University Hospital; 🇱🇻 Riga, Latvia

Health Center Adoria; 🇱🇻 Riga, Latvia

Health Center 4; 🇱🇻 Riga, Latvia

APS Clinic; 🇱🇻 Riga, Latvia

Vidzemes Hospital; 🇱🇻 Valmiera, Latvia

Mariu klinika JSC; 🇱🇹 Kaunas, Lithuania

Gita Rancane - cardiology private practice; 🇱🇻 Ventspils, Latvia

LUHS Kauno Hospital (Laisves ave.); 🇱🇹 Kaunas, Lithuania

Kardiolitos klinikos / BMP; 🇱🇹 Kaunas, Lithuania

Saules family medicine center; 🇱🇹 Kaunas, Lithuania

Hospital of LT University of Health Sciences Kaunas Clinics; 🇱🇹 Kaunas, Lithuania

InMedica clinic Zaliakalnis; 🇱🇹 Kaunas, Lithuania

Kardiologijos ir reabilitacijos klinika; 🇱🇹 Klaipeda, Lithuania

Klaipeda Republican Hospital; 🇱🇹 Klaipeda, Lithuania

Klaipeda Seamen's Hospital Cardiology Department I; 🇱🇹 Klaipeda, Lithuania

InMedica Clinic Santariskes; 🇱🇹 Vilnius, Lithuania

Hospital Sultanah Bahiyah; 🇲🇾 Alor Setar, Malaysia

Siauliai Republican hospital; 🇱🇹 Siauliai, Lithuania

Klaipedos Jurininku Ligonine; 🇱🇹 Klaipeda, Lithuania

Vilnius University Hospital Santaros Klinikos; 🇱🇹 Vilnius, Lithuania

Hospital Sultanah Aminah; 🇲🇾 Johor Bahru, Malaysia

University Hospital Kebangsaan Malaysia; 🇲🇾 Cheras, Malaysia

Hospital Raja Perempuan Zainab II; 🇲🇾 Kelantan, Malaysia

Institute Jantung Negara; 🇲🇾 Kuala Lumpur, Malaysia

University Malaya Medical Centre; 🇲🇾 Kuala Lumpur, Malaysia

Hospital Universiti Sains Malaysia; 🇲🇾 Kelantan, Malaysia

Hospital Seberang Jaya; 🇲🇾 Pulau Pinang, Malaysia

Hospital Tengku Ampuan Afzan; 🇲🇾 Pahang, Malaysia

Sarawak General Hospital; 🇲🇾 Sarawak, Malaysia

Sarawak Heart Centre; 🇲🇾 Sarawak, Malaysia

Hospital Al-Sultan Abdullah (UiTM Hospital); 🇲🇾 Selangor, Malaysia

Hospital Serdang; 🇲🇾 Selangor, Malaysia

Admiraal de Ruyterziekenhuis; 🇳🇱 Goes, Zeeland, Netherlands

Seremban Hospital Neurology; 🇲🇾 Seremban, Malaysia

Hospital Sultan Abdul Aziz Shah; 🇲🇾 Selangor, Malaysia

Amsterdam UMC | Heart Centre - Curius Research Department; 🇳🇱 Amsterdam, Netherlands

Gelre Apeldoorn Ziekenhuizen | Cardiology Department; 🇳🇱 Apeldoorn, Netherlands

Rode Kruis Ziekenhuis; 🇳🇱 Beverwijk, Netherlands

Tergooiziekenhuizen-Blaricum; 🇳🇱 Blaricum, Netherlands

Medisch Centrum Haaglanden, Locatie Westeinde; 🇳🇱 Den Haag, Netherlands

The Van Weel-Bethesda Hospital | Research Department; 🇳🇱 Dirksland, Netherlands

Catharina Hospital | Cardiology Department; 🇳🇱 Eindhoven, Netherlands

Amphia Breda | Department of Cardiology, BMC Research; 🇳🇱 Breda, Netherlands

Rivas | Beatrix Hospital Gorinchem - Cardiology Department; 🇳🇱 Gorinchem, Netherlands

Albert Schweitzer Ziekenhuis | Dordwijk - Cardiology Department; 🇳🇱 Dordrecht, Netherlands

Universitair Medisch Centrum Groningen; 🇳🇱 Groningen, Netherlands

Martini Ziekenhuis, Locatie van Swieten; 🇳🇱 Groningen, Netherlands

Spaarne Gasthuis | Haarlem Zuid - Cardiology; 🇳🇱 Haarlem, Netherlands

Saxenburgh Medisch Centrum | Cardiology Department; 🇳🇱 Hardenberg, Netherlands

Nordlandssykehuset Bodø Cardio; 🇳🇴 Bodø, Norway

Zaans Medisch Centrum | Hartvaatcentrum; 🇳🇱 Zaandam, Netherlands

VieCuri - Medisch Centrum voor Noord-Limburg locatie Venlo; 🇳🇱 Venlo, Netherlands

Vestre Viken HF - Drammen Sykehus Cardiology; 🇳🇴 Drammen, Norway

Sykehuset Innlandet HF Elverum; 🇳🇴 Elverum, Norway

Sykehus Østfold Kalnes Cardio; 🇳🇴 Fredrikstad, Norway

Sykehuset i Gjøvik Medisinsk; 🇳🇴 Gjøvik, Norway

Sykehuset Lillehammer Medicine; 🇳🇴 Lillehammer, Norway

Vestre Viken HF - Bærum Sykehus Cardiology; 🇳🇴 Gjettum, Norway

Molde Sjukehus Medisinsk; 🇳🇴 Molde, Norway

Akershus University Hospital Cardiology Department; 🇳🇴 Nordbyhagen, Norway

UNN Harstad Medisinsk avdeling; 🇳🇴 Harstad, Norway

Diakonhjemmets sykehus; 🇳🇴 Oslo, Norway

OUS Ullevål Cardiology; 🇳🇴 Oslo, Norway

Skedsmo Medisinske Senter; 🇳🇴 Skedsmokorset, Norway

UNN Tromsø Cardiology Dep.; 🇳🇴 Tromsø, Norway

Stavanger UHospital Cardiology; 🇳🇴 Stavanger, Norway

Uniwersytecki Szpital Kliniczny w Bialymstoku; 🇵🇱 Bialystok, Poland

Ålesund Sykehus, Kardiologisk Seksjon; 🇳🇴 Ålesund, Norway

KLIMED Marek Klimkiewicz; 🇵🇱 Bialystok, Poland

MICS Centrum Medyczne Bydgoszcz; 🇵🇱 Bydgoszcz, Poland

Centrum Medyczne KerMed; 🇵🇱 Bydgoszcz, Poland

Uniwersyteckie Centrum Kliniczne; 🇵🇱 Gdansk, Poland

Samodzielny Publiczny Specjalistyczny Szpital Zachodni; 🇵🇱 Grodzisk Mazowiecki, Poland

Unicardia Specjalistyczne Centrum Leczenia Ch.Serca i Naczyn; 🇵🇱 Krakow, Poland

CM MED-GASTR Sp. z o.o.; 🇵🇱 Lodz, Poland

Centrum Medyczne Ogrodowa G. i M. Kania Lekarze i Lekarze Dentysci Spólka Partnerska z siedziba w Skierniewicach; 🇵🇱 Lowicz, Poland

1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie; 🇵🇱 Lublin, Poland

Futuremeds sp. z o. o.; 🇵🇱 Olsztyn, Poland

NZOZ "Twoja Przychodnia" Sp. z o.o.; 🇵🇱 Lublin, Poland

Etyka Osrodek Badan Klinicznych; 🇵🇱 Olsztyn, Poland

NZOZ Heureka; 🇵🇱 Piaseczno, Poland

Irmed Klimkiewicz, Rudziewicz-Kowalska Sp.j.; 🇵🇱 Piotrkow Trybunalski, Poland

Solumed Centrum Medyczne; 🇵🇱 Poznan, Poland

ClinMedica Research Sp. z o.o.; 🇵🇱 Skierniewice, Poland

Velocity Pulawy; 🇵🇱 Pulawy, Poland

EMED Centrum Uslug Medycznych; 🇵🇱 Rzeszow, Poland

NBR Polska Tomasz Klodawski; 🇵🇱 Warszawa, Poland

"Nowe Zdrowie-Ck" Kieltucki I Wspolnicy Spolka Jawna; 🇵🇱 Staszow, Poland

Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji; 🇵🇱 Warszawa, Poland

KO-MED Centra Kliniczne Zamosc; 🇵🇱 Zamosc, Poland

Hospital da Senhora da Oliveira | Clinical Research Department; 🇵🇹 Guimaraes, Braga, Braga, Portugal

Centro Hospitalar Universitario Cova de Beira | Clinical Research Department; 🇵🇹 Covilha, Castelo Branco, Portugal

Centro Hospitalar Universitario de Lisboa Norte | Heart and Vessels Department; 🇵🇹 Lisbon, Lisboa, Portugal

Hospital Pedro Hispano | Clinical Research Center; 🇵🇹 Matosinhos, Porto, Portugal

Ucardio | Cardiology Department; 🇵🇹 Riachos, Santarém, Portugal

Hospital Garcia de Orta | Research Department; 🇵🇹 Almada, Setúbal, Portugal

Centro Clinico Academico Braga | Braga, Portugal; 🇵🇹 Braga, Portugal

Centro Hospitalar e Universitario de Coimbra, E.P.E. | Department of Cardiology, Research Unit; 🇵🇹 Coimbra, Portugal

Centro Hospitalar de Tamega e Sousa | Hospital Padre Americo - Cardiology Department; 🇵🇹 Guilhufe, Portugal

Centro Hospitalar de Lisboa Ocidental | Clinical Research Department; 🇵🇹 Lisboa, Portugal

Centro Hospitalar de Leiria | Santo Andre Hospital - Research Center; 🇵🇹 Leiria, Portugal

Lusiadas | Hospital Lusiadas Lisboa - Lusiadas Knowledge Center; 🇵🇹 Lisboa, Portugal

Luz Saude | Hospital da Luz Setubal - Clinical Research Department; 🇵🇹 Setúbal, Portugal

Centro Hospitalar Vila Nova de Gaia e Espinho | Unit 1 - Clinical Research Center; 🇵🇹 Porto, Portugal

Emergency County Hospital, Braila; 🇷🇴 Braila, Romania

S.C Thera Card S.R.L; 🇷🇴 Brasov, Romania

S.C. Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL; 🇷🇴 Brasov, Romania

Emergency Institute for Cardiovascular Diseases; 🇷🇴 Bucharest, Romania

Niculae Stancioiu Heart Institute Cluj-Napoca; 🇷🇴 Cluj Napoca, Romania

Spitatul Universitar de Urgenta Bucaresti; 🇷🇴 Bucuresti, Romania

Spitalul de urgenta Sf. Ioan Cel Nou; 🇷🇴 Suceava, Romania

S.C. Cardio Med S.R.L.; 🇷🇴 Targu Mures, Romania

Emergency Institute of Cardiovascular Diseases & Transplant; 🇷🇴 Targu Mures, Romania

Timisoara Institute of Cardiovascular Diseases; 🇷🇴 Timisoara, Romania

National University Hospital; 🇸🇬 Singapore, Singapore

Tan Tock Seng Hospital; 🇸🇬 Singapore, Singapore

Ng Teng Fong General Hospital; 🇸🇬 Singapore, Singapore

ALIAN s.r.o.; 🇸🇰 Bardejov, Slovakia

Kardiosanus | Bratislava, Slovakia; 🇸🇰 Bratislava, Slovakia

GALENUM s.r.o.; 🇸🇰 Bratislava, Slovakia

KardioLEV s.r.o.; 🇸🇰 Levoca, Slovakia

KardioMed | Outpatient Cardiology and Internal Medicine II Clinic; 🇸🇰 Lucenec, Slovakia

Internal and Diabetes Clinic - IN-DIA s.r.o. | Lucenec, Slovakia; 🇸🇰 Lucenec, Slovakia

KARDIO 1 | Lucenec, Slovakia; 🇸🇰 Lucenec, Slovakia

BENIMED s.r.o.; 🇸🇰 Piestany, Slovakia

MEDISPOL s.r.o.; 🇸🇰 Presov, Slovakia

Interna SK s.r.o.; 🇸🇰 Svidnik, Slovakia

Kardiologicka ambulancia Trnava, MUDr. Vladimir Macek; 🇸🇰 Trnava, Slovakia

Hospital Universitari de Bellvitge | Bellvitge Biomedical Research Institute - Cardiology - AF, Stroke Prevention; 🇪🇸 L'Hospitalet de Llobregat, Barcelona, Spain

Jose Manuel Pascual Pascual S.A. | Hospital Virgen del Camino - Internal Medicine Department; 🇪🇸 Sanlucar de Barrameda, Cádiz, Spain

Hospital Universitario Virgen de la Victoria | Cardiology Department; 🇪🇸 Malaga, Málaga, Spain

Hospital Alta Resolucion de Lebrija | Cardiology Service Department; 🇪🇸 Lebrija, Sevilla, Spain

Hospital de la Santa Creu i Sant Pau | Cardiology Department; 🇪🇸 Barcelona, Spain

Vall d'Hebron Barcelona Hospital Campus | Vall d'Hebron Hospital Universitario - Cardiology Department; 🇪🇸 Barcelona, Spain

Hospital Quironsalud Barcelona | Internal Medicine Department; 🇪🇸 Barcelona, Spain

Hospital Universitario La Paz | IdiPAZ - Neurology Department; 🇪🇸 Madrid, Spain

Hospital Universitario La Paz | Cardiology Department - AF, Stroke Prevention; 🇪🇸 Madrid, Spain

Hospital Clinico Universitario Virgen de la Arrixaca | Cardiology Department; 🇪🇸 Murcia, Spain

La Fe University and Polytechnic Hospital | Cardiology Department; 🇪🇸 Valencia, Spain

Hospital General Universitario de Valencia | Cardiology Department; 🇪🇸 Valencia, Spain

Hospital Universitario Virgen del Rocio | Hospital General - Departamento de Cardiologia y Cirugia Cardiovascular; 🇪🇸 Sevilla, Spain

Helsingborgs Lasarett; 🇸🇪 Helsingborg, Sweden

SU/Östra; 🇸🇪 Göteborg, Sweden

Universitetssjukhuset i Linköping; 🇸🇪 Linköping, Sweden

Clemenstorget Hjärtmottagning; 🇸🇪 Lund, Sweden

Skånes Universitetssjukhus; 🇸🇪 Lund, Sweden

SU/Mölndal; 🇸🇪 Mölndal, Sweden

Skellefteå Lasarett; 🇸🇪 Skellefteå, Sweden

Karolinska Universitetssjukhuset Huddinge Stockholm; 🇸🇪 Stockholm, Sweden

Södersjukhuset AB; 🇸🇪 Stockholm, Sweden

Norrlands Universitetssjukhus, Umea; 🇸🇪 Umea, Sweden

Danderyds sjukhus; 🇸🇪 Stockholm, Sweden

MacKay Memorial Hospital Tamsui Branch; 🇨🇳 New Taipei City, Taipei, Taiwan

National Yang Ming Chiao Tung University Hospital; 🇨🇳 Yilan, Ilan, Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital; 🇨🇳 Kaohsiung City, Kaohsiung, Taiwan

Mackay Memorial Hospital - Hsinchu Branch; 🇨🇳 Hsinchu, Taiwan

E-Da Hospital; 🇨🇳 Kaohsiung, Taiwan

Chang Gung Memorial Hospital Kaohsiung; 🇨🇳 Kaohsiung, Taiwan

Buddhist Tzu-Chi General Hospital, Hualien; 🇨🇳 Hualien, Taiwan

Veterans General Hospital; 🇨🇳 Kaohsiung City, Taiwan

Taichung Veterans General Hospital; 🇨🇳 Taichung, Taiwan

China Medical University Hospital; 🇨🇳 Taichung, Taiwan

Tri-Service General Hospital; 🇨🇳 Taipei City, Taiwan

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan

National Cheng Kung University Hospital; 🇨🇳 Tainan, Taiwan

Taipei Medical University | Clinical Research Center; 🇨🇳 Taipei, Taiwan

Taipei Veterans General Hospital; 🇨🇳 Taipei, Taiwan

Mackay Memorial Hospital; 🇨🇳 Taipei, Taiwan

Taipei Municipal Wanfang Hospital; 🇨🇳 Taipei, Taiwan

Shin Kong Wu Ho-Su Memorial Hospital; 🇨🇳 Taipei, Taiwan

Baskent Universitesi Tip Fakultesi Hastanesi; 🇹🇷 Ankara, Turkey

Health Ministry Of Türkiye Republic Ankara Bilkent City Hospital; 🇹🇷 Ankara, Turkey

Afyonkarahisar Saglik Bilimleri Universitesi; 🇹🇷 Afyonkarahisar, Turkey

Akdeniz Universitesi Tip Fakultesi Hastanesi; 🇹🇷 Antalya, Turkey

Eskisehir Osmangazi Universitesi Tip Fakultesi; 🇹🇷 Eskisehir, Turkey

Hitit Universitesi Tip Fakultesi; 🇹🇷 Corum, Turkey

Istanbul Universitesi Cerrahpasa - Kardiyoloji Anabilim Dali; 🇹🇷 Istanbul, Turkey

Dokuz Eylul Universitesi Tip Fakultesi; 🇹🇷 Izmir, Turkey

Istanbul Mehmet Akif Ersoy Gogus Kalp Damar Cerrahisi E.A.H.; 🇹🇷 Istanbul, Turkey

Marmara Uni. Tip Fak. Pendik EAH Kardiyoloji; 🇹🇷 Istanbul, Turkey

Kutahya Saglik Bilimleri Uni. Evliya Celebi Egitim ve Arasti; 🇹🇷 Kutahya, Turkey

Kocaeli Universitesi Tip Fakultesi; 🇹🇷 Kocaeli, Turkey

Erciyes Universitesi Tip Fakultesi; 🇹🇷 Kayseri, Turkey

Adana Sehir Egitim ve Arastirma Hastanesi; 🇹🇷 Yüregir, Turkey

Saglik Bilimleri Univ. Samsun EAH Kardiyoloji Departmani; 🇹🇷 Samsun, Turkey

Countess of Chester Hospital; 🇬🇧 Chester, Cheshire, United Kingdom

Staploe Medical Centre; 🇬🇧 Ely, Cambridgeshire, United Kingdom

Chesterfield Royal Hospital; 🇬🇧 Chesterfield, Derbyshire, United Kingdom

Poole Hospital NHS Trust; 🇬🇧 Poole, Dorset, United Kingdom

University Hospitals Leicester; 🇬🇧 Leicester, Leicestershire, United Kingdom

Glasgow Royal Infirmary | Stroke Unit; 🇬🇧 Glasgow, Glasgow City, United Kingdom

Northwick Park Hospital; 🇬🇧 Harrow, London, United Kingdom

Worcestershire Acute Hospital Trust; 🇬🇧 Worcester, Worcestershire, United Kingdom

Craigavon Area Hospital; 🇬🇧 Craigavon, North Ireland, United Kingdom

Freeman Hospital; 🇬🇧 Newcastle, Tyne And Wear, United Kingdom

Soho Health Centre, Future Meds; 🇬🇧 Birmingham, West Midlands, United Kingdom

James Cook University Hospital South Tees; 🇬🇧 Middlesborough, Yorkshire, United Kingdom

Heart and Chest Hospital; 🇬🇧 Liverpool, United Kingdom

King's College Hospital - NHS Foundation Trust; 🇬🇧 London, United Kingdom

Charing Cross Hospital; 🇬🇧 London, United Kingdom

Future Meds - Bromborough; 🇬🇧 Wirral, United Kingdom

M Health Fairview; 🇺🇸 Maplewood, Minnesota, United States

Minneapolis Heart Institute; 🇺🇸 Saint Paul, Minnesota, United States

Blacktown Hospital; 🇦🇺 Blacktownn, New South Wales, Australia

Concord Repatriation General Hospital; 🇦🇺 Concord, New South Wales, Australia

South Western Sydney Local Health District | Liverpool Hospital - Stroke and Neurovascular Department; 🇦🇺 Liverpool, New South Wales, Australia

University of Colorado Hospital - Cardiology; 🇺🇸 Aurora, Colorado, United States

Inspira Medical Centers | Clinical Research Office; 🇺🇸 Mullica Hill, New Jersey, United States

York Clinical Research, LLC | Norfolk, VA; 🇺🇸 Norfolk, Virginia, United States

Akashi Medical Center | Hyogo, Japan; 🇯🇵 Akashi-city, Hyogo, Japan

Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina; 🇦🇷 Buenos Aires, Ciudad Auton. De Buenos Aires, Argentina

University of California, Irvine; 🇺🇸 Irvine, California, United States

SEC Clinical Research; 🇺🇸 Dothan, Alabama, United States

Eastern Shore Research Institute, LLC | Fairhope, AL; 🇺🇸 Fairhope, Alabama, United States

Mobile Heart Specialists, PC; 🇺🇸 Mobile, Alabama, United States

Radin Cardiovascular Medical Group; 🇺🇸 Newport Beach, California, United States

VA Long Beach Healthcare System; 🇺🇸 Long Beach, California, United States

Amicis Research Center | Northridge, CA; 🇺🇸 Northridge, California, United States

Interventional Cardiology Medical Group | West Hills, CA; 🇺🇸 West Hills, California, United States

Integrity Clinical Research | Cardiology Associates of South Florida; 🇺🇸 Boynton Beach, Florida, United States

Cardiology Consultants, PA; 🇺🇸 Daytona Beach, Florida, United States

University of Florida - Jacksonville; 🇺🇸 Jacksonville, Florida, United States

Southwest Florida Research | Naples, FL; 🇺🇸 Naples, Florida, United States

Peace River Cardiovascular Center | Port Charlotte, FL; 🇺🇸 Port Charlotte, Florida, United States

NSC Cardiology | Johns Creek, GA; 🇺🇸 Cumming, Georgia, United States

Midwest Cardiovascular Research and Education Foundation | Elkhart, IN; 🇺🇸 Elkhart, Indiana, United States

Anderson Medical Group and Cardiology | Anderson Medical Research, LLC; 🇺🇸 Fort Washington, Maryland, United States

Oregon Health and Science University; 🇺🇸 Portland, Oregon, United States

Pennsylvania State University College of Medicine; 🇺🇸 Hershey, Pennsylvania, United States

Cardiology Consultants of Philadelphia | Yardley; 🇺🇸 Yardley, Pennsylvania, United States

Carolina Heart Specialists | Lancaster, SC; 🇺🇸 Lancaster, South Carolina, United States

Erlanger Health, Inc.; 🇺🇸 Chattanooga, Tennessee, United States

TCR Institute; 🇺🇸 Kingwood, Texas, United States

Sound Medical Research | Sound Medical Research of Port Orchard; 🇺🇸 Port Orchard, Washington, United States

Consultorios Integrados Rosario | Instituto Medico de la Fundacion de Estudios Clinicos; 🇦🇷 Rosario, Santa Fe, Argentina

Centro de Especialidades Medicas (Cemedic) | Cardiology Department; 🇦🇷 Villa Luro, Ciudad Auton. De Buenos Aires, Argentina

John Hunter Hospital; 🇦🇺 New Lambton, New South Wales, Australia

Illawarra Shoalhaven Local Health District; 🇦🇺 Wollongong, New South Wales, Australia

Advara HealthCare Wesley; 🇦🇺 Auchenflower, Queensland, Australia

Royal Adelaide Hospital; 🇦🇺 Adelaide, South Australia, Australia

The Prince Charles Hospital; 🇦🇺 Herston, Queensland, Australia

Redcliffe District Hospital; 🇦🇺 Redcliffe, Queensland, Australia

Royal Brisbane & Women's Hospital; 🇦🇺 Brisbane, Queensland, Australia

Queen Elizabeth Hospital AUS; 🇦🇺 Woodville South, South Australia, Australia

The Avenue Cardiovascular Centre; 🇦🇺 St Kilda East, Victoria, Australia

Elisabethinen Linz | Kardiologie, Angiologie & Intensiv Med; 🇦🇹 Linz, Oberösterreich, Austria

Maria Middelares General Hospital | Cardiology Department; 🇧🇪 Gent, Oost-Vlaanderen, Belgium

AZ St-Lucas Campus St-Lucas - Cardiology; 🇧🇪 Gent, Oost-Vlaanderen, Belgium

Quanta Diagnostico Por Imagem | Research and Innovation Department; 🇧🇷 Curitiba, Parana, Brazil

Instituto do Coração de Marilia | Marilia, Brasil; 🇧🇷 Marília, Sao Paulo, Brazil

Centro Medico Sao Francisco | Curitiba, Brazil; 🇧🇷 Curitiba, Parana, Brazil

Sociedade Hospitalar Angelina Caron | Departamento de Ensino e Pesquisa; 🇧🇷 Paraná, Parana, Brazil

Hospital e Maternidade Christovao da Gama | Santo Andre Medical Centre - Cardiology Department; 🇧🇷 Santo André, Sao Paulo, Brazil

Irmandade da Santa Casa de Misericordia de Sao Paulo | Hospital Central - Cardiology Department; 🇧🇷 São Paulo, Sao Paulo, Brazil

Centro de Pesquisa Clinica do Coração | Aracaju, Brasil; 🇧🇷 Aracaju, Sergipe, Brazil

Hospital Samaritano Paulista | Clinical Research Department; 🇧🇷 São Paulo, Sao Paulo, Brazil

Instituto Dante Pazzanese de Cardiologia | Divisao de Pesquisa; 🇧🇷 São Paulo, Sao Paulo, Brazil

Medical Center Rusemed EOOD | Ruse, Bulgaria; 🇧🇬 Ruse, Bulgaria

Multiprofile Hospital for Active Treatment Knyaginya Klementina Sofia EAD | Cardiology Department; 🇧🇬 Sofia, Bulgaria

The University General Hospital for Active Care and Emergency Medicine Pirogov | Cardiology Department; 🇧🇬 Sofia, Bulgaria

Medical Center Zara-Med EOOD | Cardiology Department; 🇧🇬 Stara Zagora, Bulgaria

NOVA Clinic Medical Center | Varna, BG; 🇧🇬 Varna, Bulgaria

Vancouver General Hospital; 🇨🇦 Vancouver, British Columbia, Canada

St. Joseph's Healthcare - Hamilton; 🇨🇦 Hamilton, Ontario, Canada

QEII Health Sciences Centre; 🇨🇦 Halifax, Nova Scotia, Canada

Hamilton Med.Research Group - DCT; 🇨🇦 Hamilton, Ontario, Canada

Niagara Health - St. Catharines Site; 🇨🇦 St. Catharines, Ontario, Canada

London Health Sciences Centre | University Hospital - London Heart Rhythm Program - Cardiology; 🇨🇦 London, Ontario, Canada

CHUM - Centre hospitalier de l'Université de Montréal; 🇨🇦 Montreal, Quebec, Canada

Hainan Provincial People's Hospital; 🇨🇳 Haikou, Hainan, China

Liuzhou Worker's Hospital; 🇨🇳 Liuzhou, Guangxi, China

Inner Mongolia People's Hospital; 🇨🇳 Hohhot, Inner Mongolia, China

Puai Hospital,Tongji Medical College, Huazhong Univ Sci&Tech; 🇨🇳 Wuhan, Hubei, China

Huai'an First People's Hospital, Nanjing Medical University; 🇨🇳 Huai'An, Jiangsu, China

Nanjing First Hospital; 🇨🇳 Nanjing, Jiangsu, China

Affiliated Hospital of Yangzhou University (Yangzhou First People's Hospital); 🇨🇳 Yangzhou, Jiangsu, China

The 2nd Affiliated Hospital of Shandong University; 🇨🇳 Jinan, Shandong, China

Tonghua Central Hospital; 🇨🇳 Tonghua, Jilin, China

Yuncheng Central Hospital; 🇨🇳 Yuncheng, Shanxi, China

Affiliated Hangzhou First People's Hospital, Zhejiang Univ; 🇨🇳 Hangzhou, Zhejiang, China

Jackson Heart Clinic | Jackson, MS; 🇺🇸 Jackson, Mississippi, United States

Baptist Health Medical Group - Louisville Cardiology; 🇺🇸 Louisville, Kentucky, United States

Medical University of South Carolina - Cardiology; 🇺🇸 Charleston, South Carolina, United States

Thriassio General Hospital of Elefsina; 🇬🇷 Elefsina, Greece

Louisiana Heart Center Research - Slidell; 🇺🇸 Slidell, Louisiana, United States

NJ Heart | Linden, NJ; 🇺🇸 Linden, New Jersey, United States

Ochsner Clinic Foundation; 🇺🇸 Baton Rouge, Louisiana, United States

Garden State Heart Care; 🇺🇸 Manalapan, New Jersey, United States

MaineHealth Maine Medical Center | Maine Medical Partners Cardiology; 🇺🇸 Scarborough, Maine, United States

Cardiovascular Associates Research, LLC; 🇺🇸 Covington, Louisiana, United States

Centro de Investigaciones Medicas Lanus | Buenos Aires, Argentina; 🇦🇷 Lanus, Buenos Aires, Argentina

Cooper Specialty Care at Voorhees; 🇺🇸 Voorhees, New Jersey, United States

Cardiology Associates Research, LLC; 🇺🇸 Tupelo, Mississippi, United States

Cardiovascular Research of Knoxville; 🇺🇸 Powell, Tennessee, United States

Landeskrankenhaus Hall | Abteilung fuer Innere Medizin; 🇦🇹 Hall in Tirol, Tirol, Austria

Antwerp University Hospital | Cardiology Department; 🇧🇪 Edegem, Antwerpen, Belgium

Northeast Cardiology Associates; 🇺🇸 Bangor, Maine, United States

The Valley Hospital, Inc.; 🇺🇸 Ridgewood, New Jersey, United States

Accellacare | Mt. Pleasant, SC; 🇺🇸 Ladson, South Carolina, United States

CHI Health Clinic Heart Institute - Grand Island; 🇺🇸 Grand Island, Nebraska, United States

Advanced Heart Care, LLC | Bridgewater, NJ; 🇺🇸 Bridgewater, New Jersey, United States

Klinikum Klagenfurt | Innere Medizin und Kardiologie; 🇦🇹 Klagenfurt, Kärnten, Austria

Hanusch Krankenhaus | 2. Medizinische Abteilung; 🇦🇹 Wien, Austria

ZNA Middelheim; 🇧🇪 Antwerp, Belgium

AZ Sint Blasius, Cardiology, Dendermonde; 🇧🇪 Dendermonde, Belgium

Laboratorio de Hemostasia y Trombosis | Rosario, AR; 🇦🇷 Rosario, Santa Fe, Argentina

Holston Medical Group - Bristol; 🇺🇸 Bristol, Tennessee, United States

LKH Feldkirch | Innere Medizin I mit Kardiologie; 🇦🇹 Feldkirch, Vorarlberg, Austria

Grampians Health Ballarat; 🇦🇺 Ballarat, Victoria, Australia

Barwon Health; 🇦🇺 Geelong, Victoria, Australia

Cabrini Malvern; 🇦🇺 Malvern, Victoria, Australia

Instituto de Investigaciones Clinicas Bahia Blanca | Bahia Blanca, Argentina; 🇦🇷 Bahía Blanca, Buenos Aires, Argentina

Centro de Investigación y Prevención Cardiovascular; 🇦🇷 General Arenales, Buenos Aires, Argentina

Centro de Investigaciones Medicas Temperley | Buenos Aires, Argentina; 🇦🇷 Temperley, Buenos Aires, Argentina

Instituto De Investigaciones Clinicas Zarate | Zarate, Argentina; 🇦🇷 Zárate, Buenos Aires, Argentina

Instituto de Cardiologia de Corrientes Juana F. Cabral | Corrientes, Argentina; 🇦🇷 Corrientes, Argentina

MedUni Wien | Innere Medizin II, Kardiologie; 🇦🇹 Vienna, Wien, Austria

UZ Leuven Gasthuisberg; 🇧🇪 Leuven, Vlaams Brabant, Belgium

OL Vrouwziekenhuis - Campus Aalst; 🇧🇪 Aalst, Belgium

AZ Sint-Jan Brugge-Oostende | Sint-Jan - Cardiology; 🇧🇪 Brugge, Belgium

Royal Melbourne Hospital; 🇦🇺 Parkville, Victoria, Australia

The Canberra Hospital; 🇦🇺 Garran, Australian Capital Territory, Australia

UK St. Poelten | Innere Med III; 🇦🇹 St. Poelten, Niederösterreich, Austria

Baker Heart and Diabetes Institute; 🇦🇺 Hoppers Crossing, Victoria, Australia

Instituto de Investigaciones Clinicas de Mar del Plata | Mar del Plata, Argentina; 🇦🇷 Mar del Plata, Buenos Aires, Argentina

Imelda Vzw | Study Cardiology; 🇧🇪 Bonheiden, Antwerpen, Belgium

Groeninge Algemeen Ziekenhuis | Campus Kennedylaan - Cardiology Departement; 🇧🇪 Kortrijk, West-Vlaanderen, Belgium

Second Medical Center Sofia EOOD; 🇧🇬 Sofia, Bulgaria

CIUSSS Saguenay Lac-St-Jean; 🇨🇦 Chicoutimi, Quebec, Canada

Investigaciones Clinicas Tucuman | San Miguel de Tucuman, Argentina; 🇦🇷 San Miguel de Tucumán, Tucuman, Argentina

Klinik Floridsdorf | Herz-, Gefaess- u. Kardio Ambulaz; 🇦🇹 Vienna, Wien, Austria

Algemeen Stedelijk Ziekenhuis Campus Aalst; 🇧🇪 Aalst, Belgium

General Hospital Silistra | Department of Cardiology, Structure for Interventional Cardiology; 🇧🇬 Silistra, Bulgaria

HUS Jorvin sairaala; 🇫🇮 Espoo, Finland

Algemeen Ziekenhuis Klina | Cardiology Department; 🇧🇪 Brasschaat, Belgium

Multiprofile Hospital for Active Treatment Puls | Clinical Trial Center; 🇧🇬 Blagoevgrad, Bulgaria

University Hospital for Active Treatment Tsaritsa Joanna - ISUL | Cardiology Clinic; 🇧🇬 Sofia, Bulgaria

Keski-Pohjanmaan keskussairaala; 🇫🇮 Kokkola, Finland

University General Hospital of Alexandroupolis; 🇬🇷 Alexandroupolis, Greece

University General Hospital of Patra; 🇬🇷 Patra, Greece

SHATC Sveti Georgi - Pernik | Pernik, Bulgaria; 🇧🇬 Pernik, Bulgaria

Hadassah Hebrew University Hospital Ein Kerem; 🇮🇱 Jerusalem, Israel

Centricity Research Mirabel Multispecialty; 🇨🇦 Mirabel, Quebec, Canada

Uni-Klinikum Heidelberg | Kardiologie Angiologie Pneumologie; 🇩🇪 Heidelberg, Baden-Württemberg, Germany

A.O.U. di Padova; 🇮🇹 Padova, Veneto, Italy

CLINICAL MEDICAL RESEARCH Sp. z o. o.; 🇵🇱 Katowice, Poland

Borsod-Abauj-Zemplen Varmegyei Korhaz es Egyetemi Oktatokorhaz; 🇭🇺 Miskolc, Hungary

HaEmek Medical Center | Internal Medicine C Department - Research Unit; 🇮🇱 Afula, Israel

Assuta Hospital Be'er Sheva | Heart Institute - Clinics; 🇮🇱 Beer Sheva, Israel

Chiba Tokushukai Hospital | Clinical Trial Center; 🇯🇵 Funabashi-city, Chiba, Japan

Univ. General Hospital of Ioannina; 🇬🇷 Ioannina, Greece

Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz; 🇭🇺 Szombathely, Hungary

King Edward Memorial (KEM) Hospital - Pune; 🇮🇳 Pune, India

Kasugai Municipal Hospital; 🇯🇵 Kasugai, Aichi, Japan

Hyogo Prefectural Amagasaki General Medical Center; 🇯🇵 Amagasaki, Hyogo, Japan

Omihachiman Community Medical Center; 🇯🇵 Omihachiman, Shiga, Japan

Rabin Medical Center | Beilinson Hospital - Internal Medicine C Department; 🇮🇱 Petach Tikva, Israel

Hanaoka Seishu Memorial Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

JA Toride Medical Center; 🇯🇵 Toride, Ibaraki, Japan

Tsuchiura Kyodo General Hospital; 🇯🇵 Tsuchiura, Ibaraki, Japan

Fujisawa City Hospital; 🇯🇵 Fujisawa, Kanagawa, Japan

Hiroshima City Hiroshima Citizens Hospital; 🇯🇵 Hiroshima, Japan

National Hospital Organization Kyoto Medical Center; 🇯🇵 Kyoto, Japan

Kitada Clinic; 🇯🇵 Osaka, Japan

Samson Assuta Ashdod University Hospital | Cardiology Department; 🇮🇱 Ashdod, Israel

Hillel Yaffe Medical Center | Cardiology Department; 🇮🇱 Hadera, Israel

Nakamura Cardiovascular Clinic; 🇯🇵 Itoshima, Fukuoka, Japan

LUHS Kauno Hospital (Josvainiu str.); 🇱🇹 Kaunas, Lithuania

Mita Internist and Cardiology Clinic | Hokkaido, Japan; 🇯🇵 Sapporo, Hokkaido, Japan

Miyanosawa Clinic of Internal Medicine and Cardiology; 🇯🇵 Sapporo, Hokkaido, Japan

JCHO Tokuyama Central Hospital; 🇯🇵 Shunan, Yamaguchi, Japan

Hospital de Vila Franca de Xira | Centro de Desenvolvimento e Investigacao; 🇵🇹 Vila Franca de Xira, Lisboa, Portugal

Medical Group Kosice s.r.o. | Kosice, Slovakia; 🇸🇰 Kosice, Slovakia

Toho University Sakura Medical Center; 🇯🇵 Sakura, Chiba, Japan

Oji General Hospital; 🇯🇵 Tomakomai, Hokkaido, Japan

Ziekenhuis Amstelland; 🇳🇱 Amstelveen, Netherlands

Rijnstate | Arnhem - Cardiology Department - Cardio Research; 🇳🇱 Arnhem, Netherlands

Rikshospitalet Cardiology; 🇳🇴 Oslo, Norway

Vita Longa Sp. z o.o.; 🇵🇱 Katowice, Poland

Chung Shan Medical University Hospital; 🇨🇳 Taichung, Taiwan

Torbay Hospital; 🇬🇧 Torbay, Devon, United Kingdom

North Alps Medical Center Azumi Hospital; 🇯🇵 Kitaazumi-gun, Nagano, Japan

Nippon Life Hospital; 🇯🇵 Osaka, Japan

Saga Memorial Hospital; 🇯🇵 Saga, Japan

1st Riga Clinical Hospital; 🇱🇻 Riga, Latvia

Riga East Clinical University Hospital "Gailezers"; 🇱🇻 Riga, Latvia

Bravis Ziekenhuis | Roosendaal - Cardiology Department; 🇳🇱 Roosendaal, Netherlands

Centrum Terapii Wspolczesnej; 🇵🇱 Lodz, Poland

KARDIO R s.r.o.; 🇸🇰 Kosice, Slovakia

Cathay General Hospital; 🇨🇳 Taipei, Taiwan

Tokyo Medical and Dental University Hospital; 🇯🇵 Bunkyo-ku, Tokyo, Japan

HagaZiekenhuis | Cardiology Department; 🇳🇱 Den Haag, Netherlands

Changhua Christian Hospital; 🇨🇳 Changhua, Taiwan

Nihon University Itabashi Hospital; 🇯🇵 Itabashi-ku, Tokyo, Japan

Ziekenhuis Rivierenland | Cardiology Research Department; 🇳🇱 Tiel, Netherlands

Treant locatie Scheper; 🇳🇱 Emmen, Netherlands

Lister Hospital; 🇬🇧 Stevenage, Hertfordshire, United Kingdom

Chi Mei Medical Center; 🇨🇳 Taikang, Tainan, Taiwan

Chang Gung Memorial Hospital at Linkou; 🇨🇳 Taoyuan, Taiwan

North Hampshire Hospital; 🇬🇧 Basingstoke, Hampshire, United Kingdom

St Richard's Hospital; 🇬🇧 Chichester, West Sussex, United Kingdom

Wansbeck General Hospital; 🇬🇧 Ashington, Northumberland, United Kingdom

University of North Carolina at Chapel Hill | Cardiology Department; 🇺🇸 Chapel Hill, North Carolina, United States

North Florida Foundation For Research And Education | Veterans Benefits Administration; 🇺🇸 Gainesville, Florida, United States

Ochsner Medical Center - New Orleans; 🇺🇸 New Orleans, Louisiana, United States

Hunter Holmes McGuire Veterans Affairs Medical Center; 🇺🇸 Richmond, Virginia, United States

Virginia Commonwealth University; 🇺🇸 Richmond, Virginia, United States

Edmonton Cardiology Consultants; 🇨🇦 Edmonton, Alberta, Canada

University of Alberta Hospital; 🇨🇦 Edmonton, Alberta, Canada

CHRISTUS Trinity | Mother Frances Louis and Peaches Owen Heart Hospital - Electrophysiology Clinic; 🇺🇸 Tyler, Texas, United States

Hamilton Medical Research Group; 🇨🇦 Hamilton, Ontario, Canada

Rapid City Regional Hospital; 🇺🇸 Rapid City, South Dakota, United States

Centre intégré de santé et de services sociaux de Laval, Hôp; 🇨🇦 Laval, Quebec, Canada

National Hospital Organization Tokyo Medical Center; 🇯🇵 Meguro-ku, Tokyo, Japan

Clinical Trials of America, Inc.; 🇺🇸 Mount Airy, North Carolina, United States

Universitetssjukhuset Örebro; 🇸🇪 Örebro, Sweden

Memorial University of Newfoundland; 🇨🇦 St. John's, Newfoundland and Labrador, Canada