effect and safety of turmeric on vascular function in diabetics
- Conditions
- Health Condition 1: null- Type 2 diabetes mellitus patientsHealth Condition 2: E119- Type 2 diabetes mellitus without complications
- Registration Number
- CTRI/2016/10/007401
- Lead Sponsor
- JIPMER Intramural fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 136
Native Tamilian patients with type 2 diabetes mellitus diagnosed within the past 3 months to 10 years, on stable dose of metformin with or without sulfonylureas, for at least past 3 months
1)Liver dysfunction (AST,ALT > 2 times the upper limit of normal)
2)Renal dysfunction (GFR <60 ml/min)
3)Patient with concurrent illnesses like CAD(Coronary Artery Disease), CVA( cerebrovascular accidents), PVD(Peripheral Vascular Disease), CKD( Chronic Kidney Disease)other than hypertension
4)Patients taking anti diabetic drugs other than metformin and sulfonylureas
5)Pregnant women or lactating mothers; women in reproductive age group not practicing contraceptive measures.
6)Patients who had participated in other trials in the past three months.
7)Those on other herbal medications.
8)Current smokers
9)alcoholics
10)Patients with active infections such as diabetic foot infection etc
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method carotid femoral pulse wave velocityTimepoint: baseline,1st,2nd,3rd month
- Secondary Outcome Measures
Name Time Method 1.arterial stiffness index, ankle brachial index, aortic systolic/diastolic pressures, augmentation pressure, augmentation index <br/ ><br>2. ICAM and VCAM <br/ ><br>3. adiponectin and leptin <br/ ><br>4. the adverse drug reactions(ADR)to Curcuma longaTimepoint: 1.At baseline, At the end of 1st month, 2nd month <br/ ><br>and 3rd month <br/ ><br>2.baseline and 3 months <br/ ><br>3.baseline and 3 months <br/ ><br>4.1st,2nd and 3rd month