BrainBoost - A Neurofeedback Booster for Emotion Regulation Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Borderline Personality Disorder
- Sponsor
- Christian Paret
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Change in affective instability
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
This is a proof-of-concept study that aims to test the additional value of adjuvant neurofeedback treatment for psychotherapy. Three sessions of real-time fMRI neurofeedback will be administered to N=22 patients with BPD while they receive residential Dialectical Behavior Therapy treatment. In addition, outcomes are assessed from a control group with same sample size who do not receive the treatment.
Investigators
Christian Paret
Principal Investigator
Central Institute of Mental Health, Mannheim
Eligibility Criteria
Inclusion Criteria
- •DSM-5 BPD diagnosis
- •informed consent
- •EtOH and tox negative on the day of neurofeedback
- •BSL-23 score \>=1.87 at DBT halftime
Exclusion Criteria
- •pharmacotherapy with opiates
- •standing benzodiazepines (bedtime-only benzodiazepines and anti-histamines allowed)
- •pregnancy
- •life-time diagnosis schizophrenia or bipolar disorder I
- •significant current or past neurological illness
- •BMI\<16.5
- •usual safety criteria for magnetic resonance imaging
Outcomes
Primary Outcomes
Change in affective instability
Time Frame: Before treatment, immediately after treatment + follow-up measure (3 months)
Mean successive squared differences (MSSD) of six-item negative affect scale measured via behavioural sampling using ecological momentary assessment (EMA) over four days. MSSD will be compared between baseline and post-treatment timepoints.
Secondary Outcomes
- Change in emotion regulation(Before treatment, immediately after treatment + follow-up measure (3 months))
- Change in borderline symptomatology(Before treatment, immediately after treatment + 2 follow-up measures (3 months, 6 months))
- Change in resting state brain connectivity(Before treatment, immediately after treatment + follow-up measure (3 months))
- Change in amygdala reactivity(Before treatment, immediately after treatment + follow-up measure (3 months))
- Structural changes in the brain(Before the first neurofeedback training and after the last neurofeedback training)