Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis

Phase 4

Completed

• Conditions: Osteoarthritis

• Registration Number: NCT00440661
• Lead Sponsor: Laboratoires NEGMA

Brief Summary

Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2007-02-26
• Study First Submitted QC: 2007-02-26
• Study First Posted: 2007-02-27
• Study Start: 2007-03
• Status Verified: 2007-10
• Primary Completion: 2008-10
• Study Completion: 2008-10
• Last Update Submitted: 2010-03-03
• Last Update Posted: 2010-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• Painful osteoarthritis
• Hydarthrosis (synovial effusion)

Exclusion Criteria

• large effusion
• severe pathologies
• anti-osteoarthritic treatments

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Synovial concentration of IL-1

Secondary Outcome Measures

Name	Time	Method
WOMAC
Synovial concentration of IL-6

Trial Locations

Locations (1)

Rheumatologic Institut of Montreal; 🇨🇦 Montreal, Quebec, Canada