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Clinical Trials/NCT00440661
NCT00440661
Completed
Phase 4

Exploratory Study of Some Synovial Fluid Inflammation Mediatorsunder Diacerhein in Knee Osteoarthritis Patients. Phase IV Study.

Laboratoires NEGMA1 site in 1 country96 target enrollmentMarch 2007
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ConditionsOsteoarthritis
DrugsDiacerhein

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Osteoarthritis
Sponsor
Laboratoires NEGMA
Enrollment
96
Locations
1
Primary Endpoint
Synovial concentration of IL-1
Status
Completed
Last Updated
16 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.

Registry
clinicaltrials.gov
Start Date
March 2007
End Date
October 2008
Last Updated
16 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Laboratoires NEGMA

Eligibility Criteria

Inclusion Criteria

  • •Painful osteoarthritis
  • •Hydarthrosis (synovial effusion)

Exclusion Criteria

  • •large effusion
  • •severe pathologies
  • •anti-osteoarthritic treatments

Outcomes

Primary Outcomes

Synovial concentration of IL-1

Secondary Outcomes

  • Synovial concentration of IL-6
  • WOMAC

Study Sites (1)

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