NCT00440661已完成4 期
Exploratory Study of Some Synovial Fluid Inflammation Mediatorsunder Diacerhein in Knee Osteoarthritis Patients. Phase IV Study.
Laboratoires NEGMA2 个研究点 分布在 1 个国家目标入组 96 人开始时间: 2007年3月1日最近更新:
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 96
- 试验地点
- 2
- 主要终点
- Synovial concentration of IL-1
研究概览
简要总结
Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Painful osteoarthritis
- •Hydarthrosis (synovial effusion)
排除标准
- •large effusion
- •severe pathologies
- •anti-osteoarthritic treatments
结局指标
主要结局
Synovial concentration of IL-1
次要结局
- Synovial concentration of IL-6
- WOMAC
研究者
研究点 (2)
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