NCT03618914已完成不适用
Interactive Effects of Iron Status and Inflammation on Serum Hepcidin and Erythrocyte Iron Incorporation in Young Women
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Fractional and total iron absorption
研究概览
简要总结
During inflammation hepcidin concentrations are increased, leading to a decrease in iron absorption. In iron deficiency anemia hepcidin is suppressed due to the activation of erythropoiesis. Whether inflammation or anemia has the stronger effect on hepcidin is uncertain.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI <27.5kg/m2
- •body weight <70kg
- •either non-anemic (Hb>12.5g/dl) or anemic (Hb between 8-12 g/dl and ferritin <15ng/ml)
排除标准
- •pregnant or lactating
- •chronic disease
- •inflammation defined as CRP<5mg/L; AGP<1g/L
结局指标
主要结局
Fractional and total iron absorption
时间窗: 14 days after the test meal administered 24 hours after vaccination
次要结局
- Serum transferrin(up to 36 hours)
- Serum AGP(up to 36 hours)
- Serum hepcidin(up to 36 hours)
- Serum Interleukin 6(up to 36 hours)
- Serum ferritin(up to 36 hours)
- Serum CRP(up to 36 hours)
研究者
Prof. Michael B. Zimmermann
Prof. Dr. med.
Swiss Federal Institute of Technology
研究点 (1)
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