NCT03642223CompletedNot Applicable
Relation Btw Adiposity, Inflammation & Iron Absorption:Comparison Btw Central & Peripheral Adiposity
Swiss Federal Institute of Technology1 site in 1 country121 target enrollmentStarted: September 10, 2017Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 121
- Locations
- 1
- Primary Endpoint
- Fractional and total iron absorption
Study Overview
Brief Summary
Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 55 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA
Exclusion Criteria
- •Iron Supplement or antibiotic intake within 2 weeks before study start
- •diagnosed chronic disease or gastrointestinal disorders
- •regular use of medication (except contraceptives)
- •pregnancy
- •lactation
- •blood donation or surgery within the last 4 months.
Arms & Interventions
central adiposity
Experimental
Intervention: Stable iron isotopes (Other)
peripheral adiposity
Experimental
Intervention: Stable iron isotopes (Other)
normal-weight
Active Comparator
Intervention: Stable iron isotopes (Other)
Outcomes
Primary Outcomes
Fractional and total iron absorption
Time Frame: 14days after the administration of the test meal
Secondary Outcomes
- Serum IL-6(at baseline)
- Serum AGP(at baseline)
- Serum Hepcidin(at baseline)
- Serum ferritin(at baseline)
- Serum TfR(at baseline)
- Serum CRP(at baseline)
Investigators
Prof. Michael B. Zimmermann
Prof. Dr. med.
Swiss Federal Institute of Technology
Study Sites (1)
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