The pathophysiological importance of lower esophageal sphincter distensibility in gastroesophageal reflux disease
- Conditions
- heartburn10017977
- Registration Number
- NL-OMON34232
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 27
Inclusion Criteria
9 GERD patients with a hiatal hernia
9 GERD patients with no hiatal hernia or a hiatal hernia < 2cm
9 healthy volunteers
Exclusion Criteria
Surgery of the GI tract other than appendectomy or cholecystectomy
Motility disorders of the GI tract leading to delayed gastric emptying or altered intestinal motility
Inability to stop the use of medication influencing GI motility for one week
Inability to stop the use of proton pump inhibitors for one week
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Esophagogastric junction distensibility</p><br>
- Secondary Outcome Measures
Name Time Method <p>Questionnaire scores<br /><br>Rate of TLESRs<br /><br>Rate of reflux<br /><br>LES pressure</p><br>