The Esophageal Dysfunction Plays a Key Role in the Pathogenesis of PPI-resistant Globus sensatio
Not Applicable
Recruiting
- Conditions
- dyspahgia and/or globus sensation
- Registration Number
- JPRN-UMIN000007417
- Lead Sponsor
- Kawasaki Medical School
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
All patients underwent both larygoscopy and upper gastrointestinal endoscopy to exclude organic disease.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The subjects werepatients with globus sensation. All patients underwent both larygoscopy and upper gastrointestinal endoscopy to exclude organic disease. After 4 weeks of treatment with rabeprazole sodium (20 mg daily), the patients were divided into PPI-responsive and PPI-resistant groups. Then we investigated oesophageal motility in the PPI-resistant group by a multichannel intraluminal impedance and manometry study.
- Secondary Outcome Measures
Name Time Method