Tissue and Functional Assessment of Myocardial Injury in Hodgkin Lymphoma (HL) Survivors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 133
- 试验地点
- 1
- 主要终点
- compare the prevalence of cardiac injury
研究概览
简要总结
This study will test whether cardiac MRI can improve early detection of Hodgkin lymphoma associated heart disease compared to a stress echocardiogram. By doing both stress echocardiography and cardiac MRI, we will compare the ability of the two tests to detect heart disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Classical or nodular lymphocyte predominant HL treated at Memorial Sloan-Kettering Cancer Center.
- •Age ≥ 18 years
- •Treatment for HL that included mediastinal RT at initial diagnosis or relapse.
- •≥ 5 years from last HL treatment.
排除标准
- •Primary HL diagnosis prior to
- •Additional mediastinal RT or subsequent cardiotoxic systemic therapy for secondary malignant neoplasm.
- •Known CAD/CHF (defined as documented myocardial infarction, cardiac revascularization, angiographic obstructive CAD, or decreased LV function [EF < 55%] during prior clinical care).
- •Contraindication to MRI (i.e. pacemakers, defibrillators, or aneurysm clips, or other implanted ferromagnetic objects), gadolinium (i.e. known hypersensitivity to gadolinium, advanced renal insufficiency as defined by glomerular filtration rate <30 ml/min/1.73m^2).
- •Contraindication to exercise stress testing other than the above (i.e. unstable angina or severe valvular stenosis).
研究组 & 干预措施
Hodgkin Lymphoma Survivor
This is a prospective cross-sectional study of 200 HL survivors whose treatment included mediastinal RT at initial diagnosis or relapse, and are at least 5 years from last HL treatment.
干预措施: Clinical Assessment (Other)
Hodgkin Lymphoma Survivor
This is a prospective cross-sectional study of 200 HL survivors whose treatment included mediastinal RT at initial diagnosis or relapse, and are at least 5 years from last HL treatment.
干预措施: Stress cardiac MRI (Procedure)
Hodgkin Lymphoma Survivor
This is a prospective cross-sectional study of 200 HL survivors whose treatment included mediastinal RT at initial diagnosis or relapse, and are at least 5 years from last HL treatment.
干预措施: Stress echocardiogram (Procedure)
结局指标
主要结局
compare the prevalence of cardiac injury
时间窗: 2 years
detected by cardiac MRI to that detected by stress echocardiography among a broadly representative cohort of Hodgkin lymphoma survivors.
次要结局
未报告次要终点