A Comparison of Perioperative Fluid Management Using Invasive Haemodynamical Measurement of Fluid Responsiveness (Aisys GE) and Non-invasive Measurement of Haemodynamics (ClearSight System, Edwards) During Brain Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Brain Edema
- Sponsor
- University Hospital Hradec Kralove
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- fluid balance difference
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation. This study compares fluid management using invasive measurement SPV/PPV (Aisys GE) and noninvasive haemodynamic measurement (ClarSight, Edwards).
Detailed Description
The aim of the study is to optimise fluid management and to reduce perioperative risks during brain surgery. Adequate perioperative management guided by hemodynamic monitoring can help to reduce the risk of complications and thus potentially improve outcomes. This study compares fluid management algorithms based either on invasive detection of fluid responsiveness using pulse pressure variation (PPV) and systolic pressure variation (SPV) values (Aisys GE monitoring system) in group A, or on noninvasive measurement of haemodynamics (stroke volume variation (SVV), cardiac index (CI) and systemic vascular resistance (SVR) values) (ClearSight, Edwards) in group B.
Investigators
Dostalova Vlasta, MD, PhD
principal investigator
University Hospital Hradec Kralove
Eligibility Criteria
Inclusion Criteria
- •Glasgow Coma scale 15
- •ASA Physical Status Classification System I-III
- •planed surgery for brain tumor to 5 hours
- •postoperative awakening
- •sinus rhythm
Exclusion Criteria
- •NYHA III, IV
- •BMI over 40 in females and over 35 in men
- •awake operation
- •postoperative artificial ventilation
Outcomes
Primary Outcomes
fluid balance difference
Time Frame: up to 5 hours after start of operation
the difference between fluid intake and output and losses during surgery will be calculated
Secondary Outcomes
- mean dose of norepinephrine(up to 5 hours after start of operation)
- length of postoperative stay(up to 2 month after surgery)
- level of creatinin(24 hours)
- postoperative lung dysfunction(1 day)