Post-Traumatic Knee Osteoarthritis Following Anterior Cruciate Ligament Reconstruction
- Conditions
- Anterior Cruciate Ligament InjuriesPost-Traumatic Osteoarthritis of Knee
- Registration Number
- NCT06201442
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
The purpose of this trial is to define knee joint pathomechanics (KJPM) in the first 2 years after ACL reconstruction (ACLR) and relate these KJPM with changes in articular cartilage morphology and quality.
- Detailed Description
This research project is a longitudinal prospective study. The investigators aim to define the KJPM longitudinally in the first 2 years following ACLR. The investigators relate these KJPM, combined with the cumulative mechanical exposure, to changes in articular cartilage/joint surface morphology and quality. To investigate the loading pattern on the knee joint, daily activities like walking, running and climbing stairs will be performed by the participants.
The overall goal of this research project is to investigate whether KJPM are related with early cartilage degeneration. This is a first major step towards reducing the risk for post-ACLR onset of Post-Traumatic Knee Osteoarthritis (PTOA).
Two work packages (WP) can be separated, that each have a separate aim:
WP1: The first aim of this WP (WP1.A) is to profile longitudinal changes in knee contact forces (KCFs) and knee contact pressure (KCP) distribution of the articular cartilage in the first 2 years following ACLR. Second, in WP1.B, the investigators will identify multivariate proxies of KCFs (and KCP) to improve clinical translation (for example by facilitating the development of prognostic tools for verifying KJPM in real life).
WP2: the second aim is to establish the relationship between KJPM at different time points following ACLR and (changes in) articular cartilage morphology and quality (WP2.A). Furthermore, the investigators will compare the biomechanical profile of "fast PTOA progressors" with "fast non-traumatic early osteoarthritis progressors" (WP2.B).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Knee contact forces (KCF) will be measured using a 3D motion analysis system 2 years The goal is to profile longitudinal changes in KCFs of the articular cartilage.
Using a 3D motion analysis system (Vicon, Oxford Metrics, UK), marker trajectories, ground reaction forces (AMTI, MA, USA) and muscle activations (Wireless EMG Cometa, Italy) will be measured. Subsequently a musculoskeletal modelling workflow in OpenSim will be used to calculate Knee contact forces (KCF) of the articular cartilage.Knee contact pressures (KCP) will be measured using a 3D motion analysis system 2 years Using a 3D motion analysis system (Vicon, Oxford Metrics, UK), marker trajectories, ground reaction forces (AMTI, MA, USA) and muscle activations (Wireless EMG Cometa, Italy) will be measured. Subsequently a musculoskeletal modelling workflow in OpenSim will be used to calculate Knee contact pressures (KCP) of the articular cartilage.
The patient-specific cartilage thickness distribution. 2 years The cartilage thickness will be measured using the semi-automatic segmentation from the high-resolution images (3D-FSE) of the tibiofemoral cartilage.
The patient-specific tibiofemoral cartilage quality. 2 years The cartilage quality will be examined using compositional measures such as T1rho, T1p and T2 relaxation time.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Faculty of Kinesiology and Rehabilitation Sciences
🇧🇪Leuven, Vlaams-Brabant, Belgium
Faculty of Kinesiology and Rehabilitation Sciences🇧🇪Leuven, Vlaams-Brabant, BelgiumSabine Verschueren, Prof.Contact16 32 90 70sabine.verschueren@kuleuven.be