DRKS00007125Active, not recruiting未知
Modeling of lipoprotein in patients with familial hypercholesterolemia compared to healthy subjects
niversitätsklinikum Freiburg Institut für klinische Chemie und Laboratoriumsmedizin0 sites12 target enrollmentStarted: May 19, 2015Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 12
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
- Allocation
- Non-randomized controlled study
- Masking
- Open (masking not used)
Eligibility Criteria
- Ages
- 18 Years to 75 Years (—)
- Sex
- Male
Inclusion Criteria
- •inclusion criteria for FH:
- •written consent
- •positive Simon Broome criteria (possible and definitely)
- •no lipid-lowering therapy in the 6 weeks before inclusion
- •inclusion criteria control subjects:
- •written consent
- •Patients without disorder of LDL metabolism, proven by< 200 mg/dl cholesteryl, < 150 mg/dl triglycerides and <160 mg/dl LDL-cholesteryl in fasting plasma
- •no relevant internistic deseases and no lipidlowering therapy in the 6 weeks before inclusion
Exclusion Criteria
- •1.Active Liver-disease or impairment of liver function with GOT and/or GPT > 2 x value of the Upper Limit of Normal= (ULN)
- •2.mid-level or severe renal insufficiency
- •3.TSH not im reference range
- •4.uncontrolled aterial hypertension: Diastolic RR = 105 mmHg and/or systolic RR = 160 mmHg
- •5.lipid-lowering therapy within the last 6 weeks before the screening
- •6.Smoker, alcohol abuse or other drug abuse
- •7.blood donation within the last 6 weeks before the screening
- •8.Patients with a adverse acute disease
- •9. HbA1c > 6.5%
- •10.Other important striking internistic diseases, which may alter the lipidmetabolism
Investigators
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