Modeling of lipoprotein in patients with familial hypercholesterolemia compared to healthy subjects

niversitätsklinikum Freiburg0 个研究点目标入组 12 人开始时间: 2015年1月26日最近更新: 2024年9月9日

适应症

试验速览

暂无简介。

•inclusion criteria for FH:
•Age 18-75 years
•written consent
•positive Simon Broome criteria (possible and definitely)
•no lipid-lowering therapy in the 6 weeks before inclusion
•inclusion criteria control subjects:
•Age 18-75 years
•written consent
•Patients without disorder of LDL metabolism, proven by< 200 mg/dl cholesteryl, < 150 mg/dl triglycerides
•and <160 mg/dl LDL-cholesteryl in fasting plasma
•no relevant internistic deseases and no lipidlowering therapy in the 6 weeks before inclusion
•no lipid-lowering medication 6 weeks before the first study-associated blood withdrawl and until the second visit.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 30
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 30

•1. Active Liver-disease or impairment of liver function with GOT and/or GPT > 2 x value of the Upper Limit
•of Normal= (ULN)
•2. mid-level or severe renal insufficiency
•3. TSH not im reference range
•4. uncontrolled aterial hypertension: Diastolic RR 105 mmHg and/or systolic RR 160 mmHg
•5. lipid-lowering therapy within the last 6 weeks before the screening
•6. alcohol abuse, smoking or other drug abuse
•7. blood donation within the last 6 weeks before the screening
•8. Patients with a adverse acute disease
•9. HbA1c > 6.5%
•10. Other important striking internistic diseases, which may alter the lipidmetabolism

发起方