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Clinical Trials/NCT02627157
NCT02627157
Completed
Not Applicable

Measurements of Corneal Biomechanical Properties Using a Dynamic Scheimpflug Analyzer for Young Healthy Adults in South Korea

Yonsei University1 site in 1 country472 target enrollmentDecember 2, 2015
ConditionsMyopia

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Myopia
Sponsor
Yonsei University
Enrollment
472
Locations
1
Primary Endpoint
applanation time (AT)
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

The human cornea is affected by the magnitude and velocity of both internal and external forces because the cornea has both static and dynamic resistance components. Considering these natures of the human cornea, many investigators have tried to demonstrate corneal biomechanical properties to understand these characteristics of the cornea. Corneal biomechanical properties are known to influence the accuracy of measurements in intraocular pressure (IOP) and are recognized as important factor to explain the susceptibility of development of glaucomatous damage. Until recently, the only instrument which enabled the in vivo measurements of the ocular biomechanical properties was ocular response analyzer (ORA, Reichert Ophthalmic Instruments, Depew, NY, USA).8 The ORA has been used to assess the biomechanical properties of the cornea according to the dynamic bidirectional applanation process. A dynamic Scheimpflug analyzer (corneal visualization Scheimpflug technology [Corvis ST], OCULUS, Wetzlar, Germany) has been introduced recently and has become a useful instrument for evaluating corneal biomechanical properties. The dynamic Scheimpflug analyzer captures the dynamic process of corneal deformation caused by an air puff using an ultra-high-speed Scheimpflug camera at a rate of up to 4,330 images per second. Until now, well-organized analysis on the normative data of the corneal biomechanical profiles measured with the dynamic Scheimpflug analyzer for young healthy adults has not been reported yet. Hence, in the present study, we aim to conduct normative data analysis for the corneal biomechanical properties with the dynamic Scheimpflug analyzer in a cohort of young healthy adults in South Korea.

Registry
clinicaltrials.gov
Start Date
December 2, 2015
End Date
February 1, 2016
Last Updated
7 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Participants will be included in analyses if they are 20 to 40 years of age
  • Participants who have myopia with a spherical equivalent (SE) between 0.00 and -11.00 diopters (D)

Exclusion Criteria

  • Participants will be excluded from analyses if they had previous ocular or intraocular surgery, a visual field defect, suspicious optic disc appearance, IOP ≥ 30 mmHg, or presence of corneal abnormalities such as keratoconus and forme fruste keratoconus, corneal scarring that would preclude accurate measurements.

Outcomes

Primary Outcomes

applanation time (AT)

Time Frame: 1 hour

applanation length (AL)

Time Frame: 1 hour

corneal velocity (CV)

Time Frame: 1 hour

deformation amplitude

Time Frame: 1 hour

peak distance

Time Frame: 1 hour

radius

Time Frame: 1 hour

maximal concave power

Time Frame: 1 hour

central corneal thickness (CCT)

Time Frame: 1 hour

intraocular pressure (IOP)

Time Frame: 1 hour

Study Sites (1)

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