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临床试验/NCT02627157
NCT02627157已完成不适用

Measurements of Corneal Biomechanical Properties Using a Dynamic Scheimpflug Analyzer for Young Healthy Adults in South Korea

Yonsei University1 个研究点 分布在 1 个国家目标入组 472 人开始时间: 2015年12月2日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
472
试验地点
1
主要终点
applanation time (AT)

研究概览

简要总结

The human cornea is affected by the magnitude and velocity of both internal and external forces because the cornea has both static and dynamic resistance components. Considering these natures of the human cornea, many investigators have tried to demonstrate corneal biomechanical properties to understand these characteristics of the cornea. Corneal biomechanical properties are known to influence the accuracy of measurements in intraocular pressure (IOP) and are recognized as important factor to explain the susceptibility of development of glaucomatous damage. Until recently, the only instrument which enabled the in vivo measurements of the ocular biomechanical properties was ocular response analyzer (ORA, Reichert Ophthalmic Instruments, Depew, NY, USA).8 The ORA has been used to assess the biomechanical properties of the cornea according to the dynamic bidirectional applanation process. A dynamic Scheimpflug analyzer (corneal visualization Scheimpflug technology [Corvis ST], OCULUS, Wetzlar, Germany) has been introduced recently and has become a useful instrument for evaluating corneal biomechanical properties. The dynamic Scheimpflug analyzer captures the dynamic process of corneal deformation caused by an air puff using an ultra-high-speed Scheimpflug camera at a rate of up to 4,330 images per second. Until now, well-organized analysis on the normative data of the corneal biomechanical profiles measured with the dynamic Scheimpflug analyzer for young healthy adults has not been reported yet. Hence, in the present study, we aim to conduct normative data analysis for the corneal biomechanical properties with the dynamic Scheimpflug analyzer in a cohort of young healthy adults in South Korea.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
20 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Participants will be included in analyses if they are 20 to 40 years of age
  • Participants who have myopia with a spherical equivalent (SE) between 0.00 and -11.00 diopters (D)

排除标准

  • Participants will be excluded from analyses if they had previous ocular or intraocular surgery, a visual field defect, suspicious optic disc appearance, IOP ≥ 30 mmHg, or presence of corneal abnormalities such as keratoconus and forme fruste keratoconus, corneal scarring that would preclude accurate measurements.

结局指标

主要结局

applanation time (AT)

时间窗: 1 hour

applanation length (AL)

时间窗: 1 hour

corneal velocity (CV)

时间窗: 1 hour

deformation amplitude

时间窗: 1 hour

peak distance

时间窗: 1 hour

radius

时间窗: 1 hour

maximal concave power

时间窗: 1 hour

central corneal thickness (CCT)

时间窗: 1 hour

intraocular pressure (IOP)

时间窗: 1 hour

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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