Influence of amino acids on muscle preservation and functional improvements in obese, elderly adults

Not Applicable

Completed

• Conditions: Body composition, skeletal muscle, intrahepatic lipid and physical function in obese elderly individuals; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN15814848
• Lead Sponsor: Essential Blends, LLC

Brief Summary

2021 Preprint results in https://doi.org/10.20944/preprints202101.0432.v1 (added 12/05/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36184194/ (added 03/10/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-12-31
• Study Start: 2021-02-12
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

1. Individuals from all racial, ethnic and/or cultural backgrounds
2. Between the ages of 60-85 years old
3. Body mass index of 26-40 kg/m²

Exclusion Criteria

1. Individuals with a pacemaker or other implanted metal device or object
2. Previously diagnosed with insulin-dependent diabetes, active cancer or malignancy, or a chronic inflammatory condition
3. Individuals taking medications, supplements or corticosteroids that might influence metabolism or corticosteroids
4. Any individual with a disease or condition that places them at risk or harm to themselves or others

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Measured during pre-supplementation and post-supplementation visits 4 weeks apart:<br> 1. Body weight and height measured using an electronic scale/stadiometer (Health-O-Meter, St. McCook, IL, USA)<br> 2. Body composition measured using a dual-energy x-ray absorptiometry scanner (General Electric Lunar iDXA, Madison, WI)<br> 3. Thigh skeletal muscle cross-sectional area and intrahepatic lipid measured using a molecular resonance imaging/spectroscopy (Toshiba Excelart/Vantage 1.5 T MRI/MRS imaging system, Canon, Otawara, Tochigi, Japan), muscle cross-sectional area further quantified using Osirix (Geneva, Switzerland)<br> 4. Physical function parameters including measurements of grip strength, floor transfer time and walking distance/speed<br>

Secondary Outcome Measures

Name	Time	Method
<br> Measured during pre-supplementation and post-supplementation visits 4 weeks apart:<br> 1. Blood samples collected and analyzed for metabolic, lipid and hepatic blood panels by LabCorp (1626 30th Avenue, Fairbanks, AK)<br> 2. Bone mineral density measured using a dual-energy x-ray absorptiometry scanner (General Electric Lunar iDXA, Madison, WI)<br>