Assessment of Licorice extract as local drug delivery in treatment of chronic periodontitis: A randomized clinical trial.
试验速览
- 阶段
- 1/2 期
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- reduction of clinical signs
研究概览
简要总结
Periodontal diseases are among the most common infectionsdisturbing human kind and can lead to the demolition of the periodontalligament, cementum, gingiva, and alveolar bone. Plaque is the primaryetiological factor in gingival inflammation. The progression of the disease isby microbial biofilm formation(dental plaque) which leads to periodontalinflammation and then attachment loss as well as alveolar bone loss.1
Despitethe advances in various field of medicine, oral infections and dental cariesare still considered as serious public health problems and inflict a majorburden to health care services around the world and especially in developing countries.Development of resistance against antibiotics and antiseptics is a growingcause of concern which has limited the preventive measures. Therefore, there isa continuing need to search for new antimicrobial agents. Over the last decade,plant antimicrobial activity has been studied in different region of the world.2
Licorice root [Glycyrrhiza glabraLinn] is an ancient herb that had been used as a traditional medicine and sweetenerin various parts of the world for over 4,000 years. It belongs to the peafamily (Leguminosae) which includes 30 species, along which G. glabra & G.uralensis is widely used as antibacterial and anti-inflammatory agents. Theroots and rhizomes of the licorice are used. Licorice has anti-inflammatory,antiviral, antibacterial, antispasmodic, antioxidative, antiallergic, hepatoprotective, expectorant activities.3
Asthere are no studies regarding Licorice extract as a local drug delivery, thusthis study aim to assess the efficacy of Licorice root extract as local drug deliveryas an adjunct to scaling and root planing in treatment of chronic periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 25.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Systemically healthy individual between the age group of 25-
- •2.Willingness to comply with the study protocol.
- •3.Subjects who were diagnosed with generalized chronic periodontitis with a pocket depth of ≥ 5mm.
排除标准
- •1.Subjects suffering from any known systemic diseases.
- •2.Subjects who had received any antibiotic therapy in the last 6 months.
- •3.Subjects who are smokers.
- •4.Pregnancy and lactation.
- •5.Unable or not willing to comply with the study protocol.
- •6.Any periodontal treatment within six months.
结局指标
主要结局
reduction of clinical signs
时间窗: reduction of clinical signs
次要结局
- comparing the scaling and root palning as adjuct therapy(6 months)