Analysis of microbiome in Korean Crohn's disease and establishment of its associatio
- Conditions
- Diseases of the digestive system
- Registration Number
- KCT0000901
- Lead Sponsor
- Hanyang University Guri Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 200
patients were diagnosed with Crohn's disease if they met at least 2 of the following criteria:
(1) clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectal bleeding; (2) endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, or perinanal disease; (3) radiologic findings of stricture, fistula, mucosal cobblestoning, or ulceration; (4) macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and creeping fat at laparotomy; and (5) pathologic findings of transmural inflammation and/or epithelioid granulomas. Only patients who met these criteria for at least 2 months were included.
patients with biliary or liver comorbidities
patients taken antibiotics or used colon-cleansing products for at least 3 months prior to enrolment
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pyrosequencing of microbiome
- Secondary Outcome Measures
Name Time Method microbiome-genotype-phenotype interaction