Aerobic Muscle Capacity in PPS.
Completed
- Conditions
- Postpoliomyelitis Syndrome, Neuromuscular diseases, Fatigue, Skeletal muscle, Aerobic capacityPostpoliomyelitis Syndroom, Neuromusculaire aandoeningen, Vermoeidheid, (Skelet)spieren, Aerobe inspanning
- Registration Number
- NL-OMON20931
- Lead Sponsor
- Academic Medical Center (AMC), Department of Rehabiliation
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
Patients: Diagnosis of PPS according to the criteria of March of Dimes (2000)*:
1. A confirmed history of paralytic poliomyelitis characterized by an acute illness with fever and a usually asymmetrically distributed, flaccid paresis of a varying number of muscle groups. Evidence of motor neuron loss on neurological examination with signs of residual weakness, atrophy, loss of tendon reflexes and intact sensation;
Exclusion Criteria
Patients and control subjects:
1. Disabling co-morbidity influencing the outcome parameters (including cardiopulmonary disease like chest pain, arrhythmia, pacemaker, cardiac surgery, severe dyspnoea d’effort or emphysema, epileptic seizures, poorly regulated diabetes mellitus);
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Variables for peripheral muscle properties include:<br /><br>1. Critical torque (Nm);<br /><br>2. Fatigue index (%);<br /><br>3. Rate of torque development/decline (%)These will be determined with maximal voluntary contractions and (submaximal) electrically evoked contractions of the knee extensor muscles. <br><br /><br /><br>Variables for aerobic exercise capacity include:<br /><br>1. VO2peak (ml/min/kg);<br /><br>2. VO2 at anaerobic threshold (ml/min/kg);<br /><br>3. Power output at anaerobic threshold (W);<br /><br>4. Heart rate at anaerobic threshold (bpm).<br /><br>These will be determined during graded exercise testing on a cycle ergometer.
- Secondary Outcome Measures
Name Time Method Multiple measures of muscle strength and muscle activation will be determined:<br /><br>1. Maximal Voluntary Contraction (MVC) (Nm);<br /><br>2. Voluntary Activation (%);<br /><br>3. Peripheral fatigue and Central fatigue (%).