The investigation for the impact of preoperative physical and nutritional support on the muscle strength and muscle mass, and the incidence of postoperative complications following highly invasive surgeries.

Not Applicable

• Conditions: Patients who are going to undergo major hepatectomy, pancreatoduodenectomy, subtotal esophagectomy, or total pelvic exenteration for cancer.

• Registration Number: JPRN-UMIN000020780
• Lead Sponsor: agoya University Graduate School of Medicine

Brief Summary

After the introduction of prehabilitation program, muscle mass has increased, exercise capacity has improved, and postoperative hospital stay was shortened.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-02-03
• Study Completion: 2019-02-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 156

Inclusion Criteria

Not provided

Exclusion Criteria

1.Patients who are unable to do physical training. 2. Patients with metabolic dysfunction for amino acids. 3. Patients who are allergic to apple (because Amino L40 contains apple flavor). 4. A patient who by him-/herself or his/her family rejected to participate in this study. 5. A case of emergent surgery. 6. Patients with severe complications (heart disease, pulmonary disease, renal disease, hepatic disease, etc.). 7. Patients with severe mental dysfunction. 8. Patients with severe cognitive disorder. 9. Patients who were determined inappropriate to participate in this study by attending physician.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The impact of preoperative physical and nutritional therapy on the alternation of muscle mass, muscle strength, and functional capacity. Compare the data before and after (immediately before surgery, approximately 1.5 months after initiating therapy ) the induction of preoperative physical and nutritional therapy. 2. Difference in the incidence of postoperative complications (occurred within 1 month after surgery) between patients with preoperative physical and nutritional therapy and those without (case control study).

Secondary Outcome Measures

Name	Time	Method
1. The correlation between the preoperative muscle mass and muscle strength and the incidence of postoperative complications (occurred within 1 month after surgery). 2. The correlation between the muscle mass or muscle strength loss during the acute phase after surgery and the incidence of postoperative complications(occurred within 1 month after surgery).