Hemodynamic Changes in Hypertensive Patients during Dental Extraction: Mepivacaine vs. Lidocaine

Phase 4

Completed

• Conditions: Tooth extraction, Hypertension; Tooth extraction, Hypertension, Lidocaine, Mepivacaine

• Registration Number: TCTR20231014004
• Lead Sponsor: Dr. Mohan Deshpande

Brief Summary

In comparing Lidocaine and Mepivacaine, both exhibited similar onset and volume of anesthesia. Mepivacaine, however, significantly prolonged anesthesia duration (p-value of 0.028). Blood pressure changes were comparable; both drugs led to SBP increase (p-value less than 0.0001) and Mepivacaine increased DBP (p-value of 0.03). Heart rate variations showed no significant differences. Yet, Mepivacaine provided superior pain control (p-value less than 0.0479), making it advantageous during extractions.

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-09-30
• Study Start: 2023-10-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

>18 years, Controlled hypertensives.
Systolic Blood pressure less than equal to 140 mm Hg.
Diastolic Blood pressure less than equal to 90 mm Hg.
Heart rate less than equal to 100 beats/ min.
Those declared fit by dept. of Cardiology
Patients Not on anti-platelet drugs or who are permitted to discontinue anti- platelet
drugs.

Exclusion Criteria

Patients with known allergy to amide- type anaesthetics.
Patients with a history of angioplasty, cardiac surgery, angina or myocardial infarction, cardiac arrhythmia, cardiac hypertrophy, and cardiac failure.
Patients using Heparin and warfarin.
Patients with Vascular diseases /collagen diseases and clotting disorders.
Mentally challenged patients.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood pressure Before anesthesia, post-extraction Using digital BP machine ,Heart rate Before anesthesia, after onset of anesthesia, post-extraction Using pulse oximeter

Secondary Outcome Measures

Name	Time	Method
Onset of anesthesia after injection Time lapsed after injection to onset of anesthesia,Duration of anesthesia After reversal of anesthesia Time period after injection to time of onset of post-operative pain,Volume of anesthetic solution During procedure Volume of solution injected to achieve anesthesia