A Phase Ib/II Trial of Neoadjuvant Zolbetuximab Plus Docetaxel, Oxaliplatin and S-1 Chemotherapy in Patients with Locally Advanced Gastric Cancer

Phase 1

Not yet recruiting

• Conditions: Stomach Neoplasm; Gastric (Stomach) Cancer
• Interventions: Drug: zolbetuximab; Drug: Oxaliplatin; Drug: Docetaxel; Drug: S-1

• Registration Number: NCT06732856
• Lead Sponsor: Asan Medical Center

Brief Summary

Claudin 18.2 is a promising therapeutic target overexpressed on the surface of gastric cancer cells. The addition of zolbetuximab, the monoclonal antibody targeting Claudin 18.2 to chemotherapy in two recent Phase 3 studies prolonged survival outcomes, indicating that Claudin 18.2 is a valid target in gastric cancer. Asan Medical Center researchers conducted...

Detailed Description

Although the global incidence and mortality of gastric cancer has declined in recent decades, gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death. Surgical resection is the main treatment for patients with localized gastric cancer. However, postoperative recurrences are common, and approximately 40% of patients ...

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2024-12
• Study First Submitted: 2024-12-10
• Study First Submitted QC: 2024-12-10
• Study First Posted: 2024-12-13
• Last Update Submitted: 2024-12-17
• Last Update Posted: 2024-12-20
• Study Start: 2025-03-01
• Primary Completion: 2027-12-31
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 57

Inclusion Criteria

1. Patients with newly diagnosed, pathologically confirmed, potentially resectable gastric or gastroesophageal junction adenocarcinoma

2. Subjects who are CLDN18.2 positive (VENTANA 43-14A ≥75%)

3. Patients with clinical stage T3-4/N0 or T2-4/N+ on CT according to the American Joint Committee on Cancer (AJCC) 8th edition

4. If suspected by CT, patient who has not been confirmed to have peritoneal seeding by laparoscopy

5. Subject able to provide signed informed consent form, including compliance with the requirements and contraindications specified in the informed consent form (ICF) and in this protocol

6. Patients aged 19 years or older at study entry

7. Patient with Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1

8. Patient with expected survival >12 months

9. Weight >30 kg

10. Patient without neuropathy A. Grade 1 is allowed based on NCI CTCAE v5.0. B. Grade 2 or higher is excluded based on NCI CTCAE v5.0

11. Individual with confirmed adequate normal organ and bone marrow function, as defined in the applicable items below:

    • Hemoglobin ≥9.0 g/dL

    • Absolute neutrophil count (ANC) >1.5 x 103/mcL (>1,500 per mm3)

    • Platelet count ≥100 x 109/L

    • Serum bilirubin ≤1.5 x institutional upper limit of normal (ULN)

    • AST (SGOT)/ALT (SGPT) ≤2.5 x institutional ULN

    • Measured creatinine clearance (CL) >40 mL/min or creatinine CL >40 mL/min as calculated by Cockcroft-Gault formula (Cockcroft and Gault 1976) or based on a 24-hour urine sample for determination of creatinine clearance

      1. Male creatinine CL (mL/min) = Weight (kg) x (140 - Age) / 72 x Serum creatinine (mg/dL)
      2. Female creatinine CL (mL/min) = Weight (kg) x (140 - Age) / 72 x Serum creatinine (mg/dL) x 0.85

12. Evidence of menopause, or negative urine/blood pregnancy test in premenopausal women; women with amenorrhea for at least 12 months without any other medical cause are considered menopausal. The following age requirements apply:

    • A woman under age 50 is considered menopausal if 1) she has had amenorrhea for at least 12 months without hormone therapy, and 2) her LH and FSH blood levels are at menopausal levels or she has undergone bilateral oophorectomy, hysterectomy, etc.

    • A woman aged 50 years or older is considered menopausal if

      1. she has had amenorrhea for at least 12 months without hormone therapy, or
      2. she became menopause after 1 year of amenorrhea following radiation or anticancer treatment, or
      3. she has undergone bilateral oophorectomy, bilateral salpingectomy, hysterectomy, etc.

13. Patient who is willing and able to comply with the protocol during the study, including treatments and tests such as scheduled visits, follow-up, etc.

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Exclusion Criteria

1. Patient who received investigational product in another clinical study 2 weeks prior to participation in this clinical study

2. Patient currently enrolled in another clinical study, other than the observational (non-interventional) study or follow-up period of an interventional clinical study.

3. Concomitant chemotherapy, immunotherapy, biologic or hormonal therapy. Hormonal therapies not related to treatment for cancer (e.g., hormone replacement therapy) are allowed.

4. Major surgical procedure within 28 days prior to zolbetuximab administration

5. Distant metastasis including M1 lymph node

6. Patient unable to take oral medication

7. Gastric outlet obstruction and/or severe gastrointestinal hemorrhage that restricts diet without treatment

8. Impaired intestinal absorption, including:

   • Intestinal obstruction
   • Chronic inflammatory bowel disease
   • Operation history of extended bowel resection
   • Gastric dumping syndrome

9. Patient with a history of organ transplant

10. Uncontrolled intercurrent disease including, but not limited to:

    Ongoing or active infection, congestive heart failure with symptoms, uncontrolled hypertension, unstable angina, arrhythmia, interstitial lung disease, serious chronic gastrointestinal conditions accompanied with diarrhea, mental illness or social conditions that prevent compliance with study requirements, significantly increase the risk of adverse reactions, or interfere with written consent

11. History of other primary malignancy, with the exception of:

    • Patient who is at low risk of recurrence with disease-free status for at least 5 years prior to starting chemotherapy due to curative treatment
    • Patient who is currently disease-free with cured skin cancer (except melanoma) or lentigo maligna
    • Patient who is currently disease-free with cured in situ carcinoma

12. Patient with a history of active congenital immunodeficiency

13. Active infection, such as tuberculosis, confirmed by history, physical examination, radiographic findings, and TB testing per local standards, or HIV.

    • Tuberculosis: History, physical examination, or radiological findings suggestive of active tuberculosis, or tuberculosis confirmed by tuberculosis testing per local standards (active TB is excluded and old TB is allowed)

    • For HBV infection, the patient may be enrolled if appropriately treated with antiviral agents, etc.

    • HIV

      1. HIV Ag/Ab: If reactive, exclude
      2. HIV Ag/Ab: If non-reactive, enroll

14. Pregnant or lactating woman and man or woman of childbearing potential who is unwilling to use effective contraception (from the screening period to 90 days after the last dose of zolbetuximab)

15. Individual with known allergy and hypersensitivity to the investigational product or its components

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Treatment	zolbetuximab	-
Treatment	Oxaliplatin	-
Treatment	Docetaxel	-
Treatment	S-1	-

Primary Outcome Measures

Name	Time	Method
Evaluation of R0 resection rate in patients who underwent prior chemotherapy as a clinical trial.(phase II part)	1 year	Evaluation of R0 resection rate.
Recommended phase 2 dose (RP2D) (phase Ib part)	1 year	Recommended phase 2 dose (RP2D) (phase Ib part)

Trial Locations

Locations (1)

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of