Comparison of Hypotension During Spinal Anaesthesia for C-section

Completed

• Conditions: Hypotension; Cesarean Section; Aortocaval Compression

• Registration Number: NCT05427968
• Lead Sponsor: Rawalpindi Medical College

Brief Summary

Maternal hypotension during C section has been reported due to aortocaval compression (ACC) by full term uterus in supine position. This study aimed at reporting the effect of left tilt on maternal hemodynamics.

Detailed Description

C-section is usually done in either general anesthesia or regional (epidural or spinal) anesthesia. The choice lies with the mother. In spinal anesthesia the anaesthetic agent is injected into the subarachnoid space. Hypotension in supine position that is associated with full term gravid uterus has been explained by compression of inferior venacava (IVF) and aorta. This aortocaval compression (ACC) can also cause hypotension during C- section after spinal block.

The aim of our study was to study the effect of left tilt on systolic (SBP) and diastolic blood pressure (DBP), heart rate and the frequency of phenylephrine used to maintain the blood pressure in normal range.

Study Timeline

• Study Start: 2021-12-01
• Primary Completion: 2022-02-01
• Study Completion: 2022-02-01
• Status Verified: 2022-06
• Study First Submitted: 2022-06-16
• Study First Submitted QC: 2022-06-16
• Last Update Submitted: 2022-06-16
• Study First Posted: 2022-06-22
• Last Update Posted: 2022-06-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 38

Inclusion Criteria

• Participants ≥ 18 years, undergoing Elective Caesarean Section for term singleton pregnancy, ASA I/II, were included after their consent for the participation of the study.

Exclusion Criteria

• Participants with co-morbidities (Hypertension, diabetes mellitus, cardiovascular or cerebrovascular disease and a history of coagulation disorders), any contraindication to spinal anesthesia, with multiple pregnancy, pre-eclampsia, obesity (body mass index > 30 kg.m2), intrauterine growth were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Group 1 - Supine Group	December 2021 to February 2022	Systolic blood pressures decreased significantly in the supine group
Group 2 - Left tilt Group	December 2021 to February 2022	The decrease in the diastolic blood pressure was marginally significant in the left tilt group.

Trial Locations

Locations (1)

Rawalpindi Medical University; 🇵🇰 Rawalpindi, Punjab, Pakistan