Development of a Model to Evaluate Regenerative Endodontic Techniques
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Dental Pulp Regeneration
- 发起方
- The University of Texas Health Science Center at San Antonio
- 入组人数
- 1080
- 试验地点
- 1
- 状态
- 已完成
- 最后更新
- 13年前
概览
简要总结
Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.
详细描述
The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (\~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.
研究者
Kenneth Hargreaves
Chair, Dept. of Endodontics
The University of Texas Health Science Center at San Antonio
入排标准
入选标准
- •Pre-existing indication for surgical extraction of impacted teeth
- •Age 16-65
排除标准
- •Ages less than 16 or over 65
- •No pre-existing indication for surgical extraction of impacted teeth
结局指标
主要结局
未指定