Effect of a modest salt reduction on blood pressure and surrogate markers of cardiovascular damage in patients with primary aldosteronism.
Not Applicable
Recruiting
- Conditions
- E26.0Primary hyperaldosteronism
- Registration Number
- DRKS00026030
- Lead Sponsor
- Medizinische Klinik und Poliklinik IV, LMU Klinikum München
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 38
Inclusion Criteria
diagnosis of primary aldosteronism with specific treatment using mineralocorticoid receptor antagonists
- written informed consent
Exclusion Criteria
- severe comobidities
- age below 18 years
- intended lifestyle changes (e.g. sports)
- pregnancy, or planned pragnancy within the next 6 months
- surgery or planned surgery within the next 6 months
- cardiac infarction or stroke within the last 6 months
- recently performed radiation or chemotherapy
- alcohol abuse or illegal drug use within the last 6 months
- active smoking status
- severe dietary restrictions/allergies
- other secondary causes of hypertension
- no possiibility for informent consent
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change from baseline systolic blood pressure at the end of the study
- Secondary Outcome Measures
Name Time Method Changes in<br>1) Surrogate markers of cardiovaskular risk (e.g. Proeinuria, arterial stiffness)<br>2) Body composition<br>3) Mental well-being<br>4) Taste perception for sodium chloride<br>5) Hormonell status(e.g. aldosterone, renin)<br>6) Gut microbiome and markers of inflammation/autoimmunicity<br>7) 24-hour urinary sodium and cortisol excretion