The effect of modest salt reduction on blood pressure and endothelial function in diabetic patients
Completed
- Conditions
- Cardiovascular diseaseCirculatory SystemComplications and ill-defined descriptions of heart disease
- Registration Number
- ISRCTN41450337
- Lead Sponsor
- St George's University of London (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1. Age 30 to 80 years, either sex
2. Untreated blood pressure of greater than 120/70 mmHg with impaired glucose tolerance on oral glucose tolerance test or diet controlled type two diabetes
Exclusion Criteria
1. Uncontrolled hypertension (blood pressure greater than 160/100 mmHg)
2. Type two diabetes on oral hypoglycaemic agents or insulin
3. Secondary hypertension
4. Uncontrolled heart failure or active ischaemic heart disease
5. Active malignancy or liver disease
6. Females who are pregnant, breast feeding or taking the oral contraceptive pill
7. Individuals started on lipid lowering therapy within the last three months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Casual systolic and diastolic blood pressure. Primary outcomes are measured at baseline and weeks 2, 5, 8, 11 and 14.
- Secondary Outcome Measures
Name Time Method 1. Urinary albumin excretion<br>2. Ambulatory blood pressure monitoring (ABPM)<br>3. Endothelial function <br>4. Arterial stiffness<br><br>Secondary outcomes are measured at baseline and weeks 8 and 14.