Effects of dietary sodium restriction on blood pressure in renal transplant recipients: an intervention study

Completed

Conditions: hypertensie
high blood pressure
hypertension
10082206
10038430

Registration Number: NL-OMON39389

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 42

Inclusion Criteria

- Written informed consent
- Male and female renal transplant recipients
- Transplantation performed in the UMCG/AMC
- Patients that are one year after transplantation or beyond
- 18 years or older
- Stable renal function at study entry
- Use of RAAS-blockade: either an angiotensin-converting enzyme inhibitor (ACEi) or an angiotensin receptor blocker (ARB)

Exclusion Criteria

- Blood pressure < 120/80 mmHg
- Blood pressure > 160/95 mmHg
- Complaints or signs of orthostatic hypotension
- Creatinine clearance < 30 ml/min/1.73m2
- Proteinuria > 1.5 g/24h
- Severe general diseases or mental disorders making the participation in the study impossible
- Pregnancy
- Being on a cyclosporine withdrawal regimen
- Rejection of the allograft for which a switch in immunosuppressive medication is necessary
- Drug abuse
- No sufficient knowledge of the Dutch language to participate in the study
- Participation in an other intervention study during or within a month prior to this study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Blood pressure -and use of antihypertensive medication</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Plasma NT-proBNP<br /><br>- Relative changes between low and liberal sodium intake in stroke volume,<br /><br>cardiac output and SVR and baroreflex sensitivity as measured by NexfinTM (in<br /><br>the AMC) both supine and after 5 minutes standing<br /><br>- Urinary protein and albumin excretion<br /><br>- Urinary excretion of tubulo-interstitial damage markers (e.g. KIM-1, NAG,<br /><br>NGAL, AAP, TGFB, CTFG)</p><br>