Validation of Indirect Calorimetry in Children Undergoing Non-invasive Ventilation
- Conditions
- Respiratory Insufficiency in ChildrenNutrition AssessmentNoninvasive Ventilation
- Registration Number
- NCT03824249
- Brief Summary
Nutritional status in critically ill pediatric patients is considered a fundamental prognostic factor in terms of mortality, morbidity, complications and outcome. Many studies report how predictive equations most commonly applied are inaccurate, therefore under or over estimating the body energy requirements. For this reason, actual measurement of resting energy expenditure (REE) through indirect calorimetry (IC) is considered to be a better approach.
Currently, IC is not validated during the use of non-invasive ventilation.
Aim of the present study is to validate the measurement of REE with IC in pediatric patients undergoing non-invasive ventilation through a single-limb circuit with intentional leak.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- children admitted to the Pediatric Intensive Care Unit who completed the weaning phase from non-invasive ventilation.
- age ≤ 6 years
- patients whose parents provided signed informed consent
- age > 6 years
- patients whose parents didn't provide signed informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Resting energy expenditure (REE) 1 day Resting energy expenditure expressed in kcal/kg/die
- Secondary Outcome Measures
Name Time Method Respiratory quotient (RQ) 1 day Respiratory quotient \[expressed as VCO2/VO2\]
Carbon dioxide production (VCO2) 1 day Quantity of carbon dioxide exhaled by the patients \[expressed in ml/kg/min\]
Oxygen consumption (VO2) 1 day Quantity of oxygen consumed by the patients \[expressed in ml/kg/min\]
Trial Locations
- Locations (1)
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
🇮🇹Milan, Italy
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico🇮🇹Milan, Italy